Association between <i>PPAR-γ2</i> gene polymorphisms and diabetic retinopathy risk: a meta-analysis

Li, Xuefeng; Jiang, Guang-Bin; Cheng, Shi-Yan; Song, Yafeng; Deng, Cai; Niu, Yu‐Ming; Cai, Jianwei

doi:10.18632/aging.202433

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Malecki et al [48] found that Pro12Ala polymorphism may be associated with decreased risk of DR, but the effect may be indirect. A comprehensive meta-analysis of 14 case-control studies published from 1999 to 2020 confirmed this general tendency [54] (Table 3). It should be noted, however, that authors clearly underlined the most obvious limitation of discussed studies, including, among others, study samples that are too small in size, and they often used healthy subjects-based, unstratified control groups.…”

Section: Chromosomementioning

confidence: 72%

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The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Sienkiewicz-Szłapka,

Fiedorowicz,

Król-Grzymała

et al. 2023

IJMS

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Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the development of the disease, as well as genes and polymorphisms that can affect the gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, and thus cause changes in the functioning of metabolic pathways. In this article, the screening of chromosomes and the most important genes involved in the etiology of diabetic retinopathy is presented. The common databases with manuscripts published from January 2000 to June 2023 have been taken into consideration and chosen. This article indicates the role of specific genes in the development of diabetic retinopathy, as well as polymorphic changes within the indicated genes that may have an impact on exacerbating the symptoms of the disease. The collected data will allow for a broader look at the disease and help to select candidate genes that can become markers of the disease.

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Section: Chromosomementioning

confidence: 72%

“…This leaves the question of the potential rs1801282 association with DR still open. In studies analyzing its possible association with DR pathogenesis, same as for rs1801282, no such effect (risk or protection) was found either [54] (Table 3).…”

Section: Chromosomementioning

confidence: 97%

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Sienkiewicz-Szłapka,

Fiedorowicz,

Król-Grzymała

et al. 2023

IJMS

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The Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis

Flindris,

Markozannes,

Moschos

et al. 2024

Medicina

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Background and Objectives: Recent studies have focused on the association between the risk of diabetic retinopathy (DR) and the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene; however, their results remain inconclusive. Thus, a systematic review and meta-analysis were carried out to clarify the role of these polymorphisms in the development of DR. Materials and Methods: A systematic search of electronic databases (PubMed, Scopus, and Cochrane Library) was conducted until 25 June 2024, and a reference list of relevant articles was collected, which explored the association between the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene and the risk of DR. The pooled odds ratios (OR) and 95% confidence intervals (CI) were estimated via random-effects model, and the meta-analysis was implemented by using Review Manager 5.4. Results: In total, 6 out of 182 studies, with 1888 cases (DR) and 2285 controls (without DR), were included in the meta-analysis. A statistically significant association between the rs1501299 polymorphism and the DR risk was recorded in G vs. T in the overall analysis (OR = 0.84, 95% CI = 0.72–0.99, p = <0.05, I2 = 23%, n = 5 studies). Additionally, the summary results in the subgroup analysis according to the control type were as follows: the DR versus diabetes mellitus (DM) control type revealed a statistically significant association in G vs. T: OR = 0.81, 95% CI = 0.67–0.97, p = <0.05, I2 = 27%, n = 4 studies; GG vs. GT: OR = 0.72, 95% CI = 0.53–0.98, p = <0.05, I2 = 49%, n = 4 studies; GG vs. (GT + TT): OR = 0.73, 95% CI = 0.55–0.96, p = <0.05, I2 = 44%, n = 4 studies. No significant association was observed between the rs2241766 polymorphism and the DR risk. Conclusions: The current meta-analysis supports the association between the rs1501299 polymorphism of the ADIPOQ gene and the DR risk in patients with DM.

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Association between PPAR-γ2 gene polymorphisms and diabetic retinopathy risk: a meta-analysis

Cited by 2 publications

References 49 publications

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

The Association between ADIPOQ Gene Polymorphisms and Diabetic Retinopathy Risk: A Systematic Review and Meta-Analysis

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