Association betweenHIF1Ars11549465 polymorphism and risk of prostate cancer: a meta-analysis

Abstract

The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. Nevertheless, conflicting results have been obtained. Hence, we reevaluated this issue by means of this meta-analysis, with the purpose of providing more precise conclusion on this issue. The electronic databases of PubMed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) as well as other sources were searched for relevant reports concerning on the role of HIF1A rs11549465 polymorphism in the occurrence of prostate cancer. The strength of the relationship was determined by calculating odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs). Besides, subgroup analyses by ethnicity and source of control were further performed to examine this relationship. All statistical analyses were performed using STATA software 12.0. Although HIF1A rs11549465 polymorphism showed a tendency of increasing the risk of prostate cancer, no statistical significance was detected under any genetic models. Similar results were also revealed in subgroup analyses on the basis of ethnicity and control source. Our findings indicate that HIF1A rs11549465 polymorphism may not independently play a significant role in the occurrence of prostate cancer.

Resveratrol Induces Apoptosis in Murine Prostate Cancer Cells via Hypoxia-Inducible Factor 1-alpha (HIF-1α)/Reactive Oxygen Species (ROS)/P53 Signaling

“…With respect to PC, enhanced HIF-1α expression is associated with a shorter time before a biochemical recurrence in patients undergoing surgery or radiotherapy [26,27]. HIF-1α is upregulated independent of limited oxygen via various factors such as growth factors, free radicals, and oncogenes [28, 29]. In the present study, HIF-1α expression was always elevated in the resveratrol group compared to the control group of PCCs.…”

Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications

“…Amino acids 582 is contained in a region of HIF-1α subunit which could act independently to convey inducible responses and confer transcriptional activation [ 36 , 37 ]. Previous studies revealed that HIF1A Pro582Ser polymorphism was a stable variant and showed increased transcriptional activity, which may offer enhanced HIF-1α activity under normoxic conditions [ 38 , 39 ]. It has been postulated that the enhanced activity of HIF-1α may provide increased adaptability for pseudohypoxia induced by hyperglycemia [ 12 , 19 , 40 ].…”

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

“…In addition, HIF1A promotes autophagy by altering the expression of BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), which is part of a stress adaptation mechanism that promotes tumor cell survival and avoids cell death [35,36]. Many studies have reported associations between HIF1A polymorphisms and the risks of various types of cancer, including bladder, oral, and colorectal cancers, head and neck squamous cell carcinoma, and renal cell carcinoma [37][38][39][40].…”