Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China

Abstract

Background. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic regression analysis was performed to evaluate the association between H. pylori infection and diabetes. Results. The mean age of 13,397 participants was 43.8±12 years. The prevalence of H. pylori infection and diabetes was 28.2% and 8.1%, respectively. The prevalence of diabetes was higher among H. pylori-positive participants compared with their counterparts (8.9% vs 7.8%, p=0.05). After adjustment of age, sex, family history of diabetes, smoking, education, stroke, coronary heart disease, BMI, SBP, TG, HDL-C, and LDL-C, multivariate logistic regression analysis found no association between H. pylori infection and diabetes (OR 1.02, 95% CI 0.88-1.18). Additionally, subgroup analysis indicated that H. pylori infection was significantly associated with increased risk of diabetes in the female group (OR 1.09, 95% CI 1.08-1.09). Conclusions. No significant association was found between H. pylori infection and diabetes. However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among females. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes.

Frecuencia y características asociadas a la infección por Helicobacter pylori en pacientes sintomáticos de una clínica de Cajamarca, Perú

“…De este modo, Zhang y col. (17), reportan tasas de infección superiores al 50 % en pacientes menores de 40 años comparado con los mayores de 50 años (P < 0,001); y Smith y col., informan de un 43 % en pacientes de 31 a 40 años (15). Sin embargo, en otros estudios se demuestra más probabilidad de infección en adultos mayores (12) o simplemente no se encontraron diferencias entre los grupos etarios (13,16).…”

Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

“…By acting on the hormone somatostatin, cag + strains reduce insulin secretion by the pancreas. In addition, H. pylori increase the levels of leptin and ghrelin and predispose people to obesity and diabetes [ 76 , 82 ]. H. pylori cause type II diabetes by disrupting the production and release of plasma lipoproteins and disrupting glucose tolerance and Hb1Ac levels.…”

Helicobacter pylori and unignorable extragastric diseases: Mechanism and implications

“…According to an analysis of geographical subpopulation regions, the infection risk of H. pylori in the Asian population was slightly higher than that in other populations (Mansori et al, 2020). In contrast, a cross-sectional study showed that there was no significant correlation between H. pylori and diabetes, though it has been estimated that H. pylori may be associated with an increased risk of diabetes in Chinese females (Man et al, 2020). Moreover, an ongoing clinical study may help reveal the association between diabetes and H. pylori infection by investigating the genome-wide association of H. pylori infection (PLCO-989).…”