Association Between<i>Helicobacter pylori</i>and Gastrointestinal Symptoms in Children

Spee, Leo; Madderom, Marieke; Pijpers, Maaike; Leeuwen, Yvonne van; Berger, Marjolein Y.

doi:10.1542/peds.2010-0941

Cited by 116 publications

(83 citation statements)

References 43 publications

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“…26 There was no statistical significant difference in the incidence of H. pylori infection between the symptomatic and asymptomatic group of children (42.65 and 45%, p>0.05) indicating existence of no relation between RAP and H. pylori infection. 11,[26][27][28] However, the association of recurrent abdominal pain (RAP) and H. pylori is still debatable and other studies have reported an association between the two. 29,30 On the other hand, there is evidence against this association.…”

Section: It Is Not Yet Clear Whether the Difference In Anthropometry mentioning

confidence: 99%

“…10 These first recommendations were based on the lack of proof that infection with HP is a significant cause of GI symptoms. 11 Symptoms suggestive of acute HP infection are similar to several common childhood disorders, manifesting as recurrent abdominal pain, dyspepsia, epigastric pain, diarrhea and vomiting. 12 For the diagnosis of HP infection, gastrointestinal endoscopy with tissue culture is considered to be the "gold standard".…”

Section: Introductionmentioning

confidence: 99%

“…This emphasizes the need for up-to-date guidelines with indications for investigating and treating children with HP infection. 11 The purpose of this work is to investigate whether there exists any correlation between HP infection and RAP as well as other GI symptoms in children and thereby to evaluate the clinical significance of HP infection.…”

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confidence: 99%

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Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

KhM²,

Ma³

2012

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Section: It Is Not Yet Clear Whether the Difference In Anthropometry mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

KhM²,

Ma³

2012

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“…The relationship between recurrent abdominal pain and H. pylori infection is controversial. Some studies show that H. pylori is more frequent in patients with RAP compared to asymptomatic children, while others do not find an association between RAP and H. pylori infection [23][24][25][26][27][28][29][30]. H. pylori infection has also been reported with nonspecific symptoms, such as epigastric pain, dyspepsia, halitosis, nausea, vomiting and retrosternal pain.…”

Section: Discussionmentioning

confidence: 99%

Novel vacA s1d signal sequence found in Helicobacter pylori from Mexican Children with Recurrent Abdominal Pain

Morales-Espinosa¹

2017

SOJMID

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“…Birçok çalışmada H. pylori ile TKA arasında ilişki bulunmamış ve TKA olan ço-cuklarda H. pylori taramasının gerekli olmadığı belirtilmiştir. [15][16][17][18][19][20] Kronik gastrik inflamasyonun sitokin salınımı aracılığı ile viseral hiperaljeziye yol açtığı ve H. pylori'nin rektoviseral gastrokolonik refleksin tetiklenmesinde rol alabileceği düşünül-mektedir. 8 Ülkemizde sağlıklı çocuklarda H. pylori sıklığı 13 C-üre nefes testi ile %50-56 olarak bulunmuştur, TKA'sı olan çocukların %36-49'unda ise H. pylori organik neden olarak bildirilmiştir.…”

Section: Bulgularunclassified

Recurrent Abdominal Pain in Children: Is it Organic or Functional?

Kırşaçlıoğlu¹,

Kuloğlu²,

Üstündağ³

et al. 2016

Turkiye Klinikleri J Pediatr

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74Çocuklarda Tekrarlayan Karın Ağrısı:Organik mi, Fonksiyonel mi?Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda sık görülen bir durum olan tekrarlayan karın ağrısı organik ya da fonksiyonel olabilmektedir. Bu çalışmada, tekrarlayan karın ağrısına yol açan parazitozlar, çöl-yak hastalığı, idrar yolu enfeksiyonu, Helicobacter pylori enfeksiyonu gibi organik nedenlerin değerlendirilmesi ve fonksiyonel gastrointestinal bozuklukların belirlenmesi amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya başka bilinen bir hastalığı olmayan ve ilaç kullanmayan, en az üç ay süreyle en az üç kez tekrarlayan karın ağrısı olan çocuklar dâhil edildi. Ağrı karakteri, laboratuvar bulguları, radyolojik incelemeler, histopatolojik bulgular geriye dönük olarak değer-lendirildi. B Bu ul lg gu ul la ar r: : Çalışmaya ortalama yaşı 10,7±3,4 (4-17) yıl olan, ortanca 12 (3-20) aydır tekrarlayan karın ağrısı olan 151 (%57,6'sı kız) hasta alındı. Roma III kriterlerine göre; 81 (%53,6) hastada fonksiyonel gastrointestinal bozukluk, 70 (%46,4) hastada karın ağrısına yol açabilecek organik bir neden saptandı. Fonksiyonel ve organik nedenler arasında yaş, cinsiyet, ağrı süresi ve ağrı özellikleri açısından fark bulunmadı. Fonksiyonel gastrointestinal bozukluklar arasında en sık (%62,9) fonksiyonel karın ağrısı saptandı. Organik nedenli tekrarlayan karın ağrısı olan hastaların %46'sında Helicobacter pylori enfeksiyonu, %10,5'inde dışkıda parazit yumurtası, %3,9'unda biyopsi destekli çölyak hastalığı saptandı. S So on nu uç ç: : Fonksiyonel ve organik karın ağrısının ayırt edilmesinde yaş, cinsiyet, ağrı özellikleri, eşlik eden başka yakınmalar, fizik inceleme bulguları açısından bir fark saptanmamıştır. Çölyak hastalığı, tekrarlayan karın ağrısı olan bütün çocuklarda taranmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Çocuk; çölyak hastalığı; karın ağrısı; Helicobacter pylori A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recurrent abdominal pain is common in childhood, it may be functional or associated with organic disease. Evaluation of organic causes of recurrent abdominal pain such as parasitic enfestations, celiac disease, uriner tract infection, Helicobacter pylori infection and determine functional gastrointestinal disorders in children were aimed in the study. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Children with recurrent abdominal pain more than three times in frequency, for at least three months duration, without a known medical history and drug usage were recruited to study. Medical records were evaluated for pain characteristics, laboratory, radiological and histopathological findings, retrospectively. R Re es su ul lt ts s: : A hundred and fifty-one children [(57.6% female, mean age 10.7±3.4 (4-17) years] with recurrent abdominal pain for median 12 (3-20) months, were recruited to study. According to Rome III criteria; 81 (53.6%) patients had functional gastrointestinal disorders, 70 (46.4%) patients had an organic etiology. There was no difference between function...

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Association BetweenHelicobacter pyloriand Gastrointestinal Symptoms in Children

Abstract: We found no association between RAP and H pylori infection in children and conflicting evidence for an association between epigastric pain and H pylori infection. We found evidence for an association between UAP but could not confirm this finding in children seen in primary care.

Cited by 116 publications

References 43 publications

Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

Novel vacA s1d signal sequence found in Helicobacter pylori from Mexican Children with Recurrent Abdominal Pain

Recurrent Abdominal Pain in Children: Is it Organic or Functional?

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