Association betweenFaecalibacterium prausnitziiReduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature

Abstract

Background. Laboratory data suggests a reduction of Faecalibacterium prausnitzii (F. prausnitzii) is confirmed both in fecal samples in inflammatory bowel disease (IBD) patients. Numerous observational studies have suspected dysbiosis, an imbalance between protective and harmful bacteria to be relevant to the etiology and pathogenesis of IBD. Methods. Medline, EMBASE, Pubmed, and others. were searched by 2 independent reviewers. Of 48 abstracts reviewed, 11 studies met our inclusion criteria (subject N = 1180). Meta-analysis was performed with Review Manager 5.2. Results. The bacterial count of F. prausnitzii in IBD patients was significantly lower (6.7888 ± 1.8875) log10 CFU/g feces than healthy controls (7.5791 ± 1.5812) log10 CFU/g feces; P < 0.0001. The Standardization Mean Difference of F. prausnitzii in IBD patients was −0.94 (95% confidence interval [CI]: −1.07–−0.80). Subgroup analyses revealed a trend toward a greater effect for CD (SMD: −1.13, 95% CI: −1.32–−0.94) when compared to UC (SMD: −0.78, 95% CI: −0.97–−0.60). Conclusions. The abundance of F. prausnitzii was decreased in IBD patients compared with healthy controls. Furthermore, the reduction of F. prausnitzii and misbalance of the intestinal microbiota are particularly higher in CD patients with ileal involvement.

Gut microbiota composition associated with stool consistency

“…Many of these bacteria have previously been associated with various phenotypes, including the association of Christensenellaceae and Archaea with a lower BMI, 4 and decreased abundance of F. prausnitzii in patients with IBD. 5 Consistent with these findings, we observed a moderate but significant correlation of BMI with BSS type (Spearman's r=0.07, p=0.016).…”

Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota

“…Analyses of the microbiota in patients with IBD have demonstrated that changes in the microbiota correlate with onset of disease [29] . In particular, patients with IBD have lower levels of overall microbial biodiversity, relatively reduced levels of bacteria of the phylum Firmicutes and particularly low levels of the bacterium Faecalibacterium prausnitzii [29,30] . F. prausnitzii is known to demonstrate anti-inflammatory properties and may function to prevent aberrant inflammatory responses in healthy individuals [31] .…”

Contentious host–microbiota relationship in inflammatory bowel disease – can foes become friends again?

“…F. prausnitzii was first found to be depleted in the mucosa CD patients and its low levels were associated with higher rate of relapse of CD after resection therapy [70,71] and later, the findings were repeated in UC patients [71,72]. A recent metaanalysis showed that fecal counts of F. prausnitzii are significantly lower as in IBD patients, particularly in CD, than in healthy controls [73]. The antiinflammatory effects of F. prausnitzii have been studied by using both in vitro and in vivo models.…”