Association between hypoxemia and anemia following arthroplasty: A pilot clinical study

Gao, Fuqiang; Sun, Wei; Guo, Wanshou; Cheng, Liming; Li, Zirong; Kush, Nepali

doi:10.3892/etm.2016.3113

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Additionally, radiation‐induced hypoxia and inflammation may intensify one another, leading to a vicious cycle of hypoxia and inflammation. Low Hb levels have been linked to tissue hypoxia and increased expression of genes involved in hypoxia, profibrotic molecule synthesis (TGF‐β1, PDGFC, and PAI‐1), and the fibrosis process (LOX, P4HA1, and P4HB; Gao et al, 2016). As a result, it is fair to assume that the increased incidence of RIT in patients with low Hb (41.9% vs. 7.3%) and anemia (37.6% vs. 4.4%) in our study may be at least partially explained by the complicated interactions between hypoxia, intensified inflammation and hastened fibrosis processes (Garrido et al, 2015; Somay, Yilmaz, Topkan, Kucuk, Haksoyler, et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, radiation-induced hypoxia and inflammation may intensify one another, leading to a vicious cycle of hypoxia and inflammation. Low Hb levels have been linked to tissue hypoxia and increased expression of genes involved in hypoxia, profibrotic molecule synthesis (TGF-β1, PDGFC, and PAI-1), and the fibrosis process (LOX, P4HA1, and P4HB; Gao et al, 2016). As a result, it is fair to assume that the increased incidence of RIT in patients with low Hb (41.9% vs.…”

Section: Ta B L Ementioning

confidence: 99%

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Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer

et al. 2023

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PurposeTo investigate the predictive significance of hemoglobin (Hb) values in the incidence of radiation‐induced trismus (RIT) in locally advanced nasopharyngeal carcinoma (LA‐NPC) patients who received concurrent chemoradiotherapy (C‐CRT).MethodsData of LA‐NPC patients were examined before and after C‐CRT and to confirm the presence of RIT, maximum mouth openings (MMO) were measured; RIT is defined as an MMO of ≤35 mm. All Hb values were derived from complete blood count tests obtained on the first day of C‐CRT. The receiver operating characteristic (ROC) curve analysis was used to scrutinize a possible connection between pre‐treatment Hb values and RIT status.ResultsTwo hundred and twenty three patients were included in the study and RIT was diagnosed in 46 (20.6%) patients. The Hb cutoff in ROC curve analysis that separated the patients into two groups was 12.05 g/dL [Area under the curve (AUC): 82.7%; sensitivity: 72.9%; and specificity: 71.3%]. RIT was significantly more prevalent in the Hb ≤ 12 g/dL group than in its counterpart (41.9% vs. 7.3%; p < 0.001). In multivariate analysis, Hb ≤ 12, anemia, pre‐C‐CRT MMO < 41.4 mm, and masticatory apparatus doseV58 Gy < 32% groups were found to be independently associated with significantly increased rates of RIT.ConclusionLow pre‐C‐CRT Hb and anemia status are novel biological markers that independently predict higher RIT rates in LA‐NPC undergoing C‐CRT.

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Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer

et al. 2023

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“…Hypoxemia was defined as a desaturation nadir of SpO 2 <90%, and severe hypoxemia was defined as SpO 2 <70%. [13] Patients with acute stroke are at risk of respiratory compromise due to aspiration, upper airway obstruction, hypoventilation, and neurogenic pulmonary edema. The combination of poor perfusion and hypoxemia exacerbates and extends ischemic brain injury and has been associated with worse outcomes.…”

Section: Introductionmentioning

confidence: 99%

Application of multidisciplinary in situ simulation training in the treatment of acute ischemic stroke: a quality improvement project

Huang,

Yang,

Yao

et al. 2024

World Journal of Emergency Medicine

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BACKGROUND: Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity, mortality, and disability. Early reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic stroke. The purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-toimage time.METHODS: This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise. A total of 53 participants completed the two-day in situ simulation training. The main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training. A 5-point Likert scale was used to measure participant comfort. A paired-sample t-test was used to compare the mean self-reported comfort scores of participants, as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation training. The door-to-image time before and after the training was also recorded. RESULTS:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image time. For the emergency management of hypoxemia or tracheal intubation, the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score (hypoxemia: 4.53±0.64 vs. 3.62±0.69, t= -11.046, P<0.001; tracheal intubation: 3.98±0.72 vs. 3.43±0.72, t= -6.940, P<0.001). We also observed a decrease in the tracheal intubation and door-to-image time and a decreasing trend in the door-to-image time, which continued after the training.CONCLUSION: Our study demonstrates that the implementation of in situ simulation training in a clinical environment with a multidisciplinary approach may improve the ability and confi dence of stroke team members, optimize the fi rst-aid process, and eff ectively shorten the door-to-image time of stroke patients with emergency complications.

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Insights into the molecular mechanisms of malnutrition‐associated steatohepatitis: A review

Sharma,

Patial

2024

Liver International

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Malnutrition is a public health epidemic mainly targeting poverty‐stricken people, young ones, older people, pregnant women, and individuals with metabolic disorders. Severe malnutrition is linked with several metabolic defects, such as hepatic dysfunction, hypertension, cardiovascular disease, and osteoarthritis. The proper functioning of the liver plays a crucial role in ensuring the supply of nutrients to the body. Consequently, inadequate nutrition can lead to severe periportal hepatic steatosis due to compromised mitochondrial and peroxisome functions. Reduced protein intake disrupts essential metabolic processes like the TCA cycle, oxidative phosphorylation, and β‐oxidation, ultimately affecting ATP production. Furthermore, this can trigger a cascade of events, including disturbances in amino acid metabolism, iron metabolism, and gut microbiota, which activate genes involved in de novo lipogenesis, leading to the accumulation of lipids in the liver. The condition, in prolonged cases, progresses to steatohepatitis and liver fibrosis. Limited therapeutic solutions are available; however, few dietary supplements and drugs have demonstrated positive effects on the growth and health of malnourished individuals. These supplements improve parameters such as inflammatory and oxidative status, reduce triglyceride accumulation, enhance insulin sensitivity, and downregulate gene expression in hepatic lipid metabolism. This review elucidates the various mechanisms involved in malnutrition‐associated steatohepatitis and provides an overview of the available approaches for treating this condition.

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Association between hypoxemia and anemia following arthroplasty: A pilot clinical study

Cited by 3 publications

References 30 publications

Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer

Low hemoglobin levels predict increased radiation‐induced trismus rates in nasopharyngeal cancer

Application of multidisciplinary in situ simulation training in the treatment of acute ischemic stroke: a quality improvement project

Insights into the molecular mechanisms of malnutrition‐associated steatohepatitis: A review

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