Association between hypoglycaemic events and fall‐related fractures in Medicare‐covered patients with type 2 diabetes

Abstract

ICD-9-CM-coded outpatient hypoglycaemic events were independently associated with an increased risk of fall-related fractures. Further studies of the relationship between hypoglycaemia and the risk of fall-related fractures are warranted.

Meta-analysis: Association between hypoglycaemia and serious adverse events in older patients

“…We screened 1273 citations and included 17 studies with a total of 1498358 participants in the meta-analysis (Bonds et al, 2010, Chiba et al, 2015, Duckworth et al, 2011, Hsu et al, 2013, Origin Trial Investigators et al, 2013, Johnston et al, 2012, Johnston et al, 2011, Khunti et al, 2015, Majumdar et al, 2013, McCoy et al, 2012, Rajpathak et al, 2015, Rathmann et al, 2013, Signorovitch et al, 2013, Zhao et al, 2012, Zoungas et al, 2010. The flow chart of the study selection in shown in the supplementary eFigure.…”

“…We included three studies for fractures (Johnston et al, 2012) ( Rajpathak et al, 2015) with a pooled odds ratio of 1.92 (95% Confidence Interval 1.56, 2.38) and substantial heterogeneity (chi-squared p= 0.07, I 2 =63%).…”

The role of amylin in the development of diabetic osteopathy

“…У пациентов с СД 1-го типа, проявившимся в подростковом или молодом возрасте, костная ткань не достигает пиковой массы, происходит нарушение формирования кости, что стано-вится основополагающим фактором развития остеопении [3]. У пациентов с СД 2-го типа ми-неральная плотность кости может оставаться высокой.…”

Comment on Weber et al. Type 1 Diabetes Is Associated With an Increased Risk of Fracture Across the Life Span: A Population-Based Cohort Study Using The Health Improvement Network (THIN). Diabetes Care 2015;38:1913–1920

“…Microvascular complications such as retinopathy and/or neuropathy in people with long-standing type 1 diabetes put them at high risk for falls. A study in type 2 diabetes showed that hypoglycemia also increases the risk for fractures (5). Therefore, it is likely that hypoglycemia and falls might have contributed to the increased fracture incidence in this population with type 1 diabetes.…”

“…Studies have suggested that falls contribute to the majority of hip and lower-extremity fractures (4,5). Microvascular complications such as retinopathy and/or neuropathy in people with long-standing type 1 diabetes put them at high risk for falls.…”