Association between hypertensive disorders of pregnancy and the risk of asthma, eczema and allergies in offspring: A systematic review and meta‐analysis

Conlan, Nicola; Maher, Gillian M.; Khalaf, Sukainah Y. Al; McCarthy, Fergus P.; Khashan, Ali S.

doi:10.1111/cea.13754

Cited by 7 publications

(4 citation statements)

References 35 publications

(275 reference statements)

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“…Furthermore, hypertension during pregnancy was a mediator of the association of higher pregestational BMI with allergy traits around the 2nd year of life. Thus, the effect of hypertension during pregnancy on allergy traits might be explained by increased inflammation in the uterus, resulting in an irregular distribution of T cells, increasing IgE in the fetus and the risk of allergic disease, a mechanism already proposed for preeclampsia [29].…”

Section: Discussionmentioning

confidence: 96%

Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study

et al. 2022

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Background Allergic status has been strongly influenced by early exposures; however, allergic diseases are hard to measure in early life. Thus, this study proposed a latent variable allergy traits around the second year of life and analyzed pre- and perinatal factors associated with this phenomenon. Methods The study used data from the BRISA birth cohort, Ribeirão Preto, Brazil (n = 3644). The theoretical model included: family allergy (history of allergic rhinitis, atopic dermatitis, and asthma); gestational period variables (socioeconomic status, mother’s skin color, pregestational body mass index – BMI, smoking, gestational diabetes, and hypertension); birth variables (gestational age, 5-minute Apgar score, birth weight, type of delivery), and early life factor (exclusive breast feeding). The outcome was allergy traits around the 2nd year of life, a latent variable deduced from the shared variance among medical diagnosis of allergic rhinitis, atopic dermatitis, and food allergy. The model was analyzed by structural equation modeling. Results Higher socioeconomic status (SC = 0.256; p < 0.001) and higher family allergy values (SC = 1.224; p < 0.001) were associated with higher allergy trait values. Hypertension during pregnancy was associated with higher values (SC = 0.170; p = 0.022) and exclusive breast feeding (SC = -0.192; p < 0.001) with low allergy trait values. Conclusion Although socioeconomic and environmental factors were associated with allergy traits around the 2nd year of life, the family component of allergy was the exposure that best explained this outcome.

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Section: Discussionmentioning

confidence: 96%

Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study

et al. 2022

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“…demonstrating that offspring exposure to HDP in utero is associated with metabolic syndrome, 6 mental and behavioral disorders, 7 asthma, 8 and other conditions. Several reviews have shown that offspring born to mothers with HDP have higher blood pressure (BP).…”

Section: Introductionmentioning

confidence: 99%

“…HDP are divided into hypertension known before pregnancy or present in the first 20 weeks, including chronic hypertension, white‐coat hypertension, and masked hypertension, and hypertension arising de novo at or after 20 weeks, including gestational hypertension (GH), preeclampsia (PE) de novo or superimposed on chronic hypertension, and transient GH 5 . Previous studies have confirmed that women who develop HDP have an increased risk of cardiovascular disease later in life, while there have been studies demonstrating that offspring exposure to HDP in utero is associated with metabolic syndrome, 6 mental and behavioral disorders, 7 asthma, 8 and other conditions. Several reviews have shown that offspring born to mothers with HDP have higher blood pressure (BP) 9 .…”

Section: Introductionmentioning

confidence: 99%

Association between hypertensive disorders during pregnancy and elevated blood pressure in offspring: A systematic review and meta‐analysis

Mao

et al. 2022

J of Clinical Hypertension

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Hypertensive disorders during pregnancy (HDP) are associated with cardiovascular disease among mothers and offspring. This meta-analysis was conducted to further explore the associations between maternal HDP and offspring blood pressure (BP). The authors performed a search strategy in PubMed, Embase, Web of Science, and Cochrane library from database inception to January 2022. Twenty-four studies regarding HDP were included, with pregnancy-associated hypertension (PAH), preeclampsia (PE), gestational hypertension (GH), and chronic hypertension included in 12, 16, 6, and 3 studies, respectively. Offspring who were exposed to HDP and PAH

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“…Currently, most original articles and meta-analyses focus on the association between asthma in offspring and complications of gestational hypertension, such as preeclampsia, which has been identified as an independent factor for asthma in childhood (15)(16)(17). However, the strength of the association between gestational hypertension and offspring atopic diseases remains elusive.…”

mentioning

confidence: 99%

Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study

Yang,

Lin,

Lin

2023

Front. Pediatr.

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IntroductionGestational hypertension can lead to complications, such as preeclampsia. Preeclampsia is one of leading causes of perinatal morbidity and mortality. Abnormal placentation, immune dysregulation, and maternal inflammatory response are possible etiologies. The burden of atopic diseases is increasing worldwide. Prenatal exposure might play a role in the pathogenesis of these two diseases. The aim of this study was to evaluate the association between gestational hypertension and atopic diseases from a nationwide perspective.Material and methodsThe primary data were retrieved from Taiwan's National Health Insurance Research Database. The Maternal and Child Health Database was used to generate links between mothers and children. From 2004 to 2019, mothers with a diagnosis of gestational hypertension were identified as cases. The control groups were matched to the cases by maternal age, neonatal gender, date of birth, at a control-to-case ratio of 4:1. Each child was reviewed to confirm the diagnosis of atopic disease. Covariates including both maternal and neonatal factors were also collected.ResultsA total of 1,935,874 primiparas were enrolled in this study. After excluding 16,851 mothers with a history of hypertension, a total of 1,919,023 offspring were included in the study for the period 2004–2019. Gestational hypertension was associated with asthma (HR, 1.12, 95% CI, 1.02–1.23) and atopic dermatitis (HR, 1.10, 95% CI, 1.00–1.21) in offspring after controlling for cofactors. Nevertheless, gestational hypertension did not play an independent factor for allergic rhinitis (HR, 1.02, 95% CI, 0.95–1.10) or urticaria (HR, 1.02, 95% CI, 0.91–1.15).ConclusionMaternal gestational hypertension increases the cumulative risk for asthma and atopic dermatitis in offspring.

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Association between hypertensive disorders of pregnancy and the risk of asthma, eczema and allergies in offspring: A systematic review and meta‐analysis

Cited by 7 publications

References 35 publications

Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study

Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study

Association between hypertensive disorders during pregnancy and elevated blood pressure in offspring: A systematic review and meta‐analysis

Gestational hypertension and risk of atopic diseases in offspring, a national-wide cohort study

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