Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study

Wang, I‐Kuan; Muo, Chih‐Hsin; Chang, Yen Jung; Liang, Ching‐Chung; Chang, Chiz‐Tzung; Lin, Shih‐Yi; Yen, Tzung‐Hai; Chuang, Feng‐Rong; Chen, Pei Chun; Huang, Chiu‐Ching; Wen, Chi‐Pang; Sung, Fung‐Chang; Morisky, Donald E.

doi:10.1503/cmaj.120230

Cited by 145 publications

(123 citation statements)

References 33 publications

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“…14,[33][34][35] Information available in the inpatient claims consists of patient demographic status, registered medical facilities, and treatment provided. The identification numbers of patients used for linking data files are scrambled before being released to users to protect the privacy of insured residents.…”

Section: Methods Data Sourcementioning

confidence: 99%

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

Tseng¹,

Huang²,

Muo

et al. 2015

JNS

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Stroke, either ischemic stroke or intracerebral hemorrhage (ICH), is the leading cause of disability and one of the leading causes of death in adults. 10,28,31 Patients with ICH are at higher risk of disability than those with ischemic stroke, inclusive of greater economic and health care burdens. Exhibiting in 10%-20% of all strokes, ICH has been associated with both noninfectious and infectious factors. Studies have shown that intravenous drug use-related systemic infections increase the risk of cerebral vascular infection and subsequent rupture of mycotic aneurysms in cerebral arterioles. 9,15,32 Among noninfectious factors, pathological changes in the cerebral arterioles, including proliferation and death of arteriolar smooth muscle cells and arteriolar ectasia with microaneurysm formation 31 in the cerebral arterioles, may subsequently lead to the rupture of arteriolar microaneurysms, causing ICH. 10,28,31 These noninfectious pathological changes can be triggered by some conventional risk factors for ICH, such as hypertension, diabetes, hyperlipidemia, and chronic kidney disease (CKD). 16,18,20,21,24 However, risk factors for 10%-25% of ICH patients remain unclear, especially in the younger population. 16,18,21,24 Studies have documented well the role of chronic inflammation in triggering arterial ectasia and microaneurysm formation in the coronary artery. 7,21,24 Studies have also associated ICH with similar chronic inflammatory abbreviatioNs CKD = chronic kidney disease; COM = chronic osteomyelitis; HR = hazard ratio; ICH = intracerebral hemorrhage; IR = incidence rate; IRR = incidence rate ratio; NHI = National Health Insurance; RA = rheumatoid arthritis; SLE = systemic lupus erythematosus; VZV = varicella-zoster virus. obJect Inflammation may provoke cerebral arteriolar ectasia, inducing microaneurysm formation and further promoting intracerebral hemorrhage (ICH). Chronic osteomyelitis (COM) is an inflammatory disorder for which study of its role in ICH is lacking. This study explored whether COM increases the risk of ICH. methods From Taiwan national insurance inpatient claims, 22,052 patients who were newly diagnosed with COM between 1997 and 2010 were identified; 88,207 age and sex frequency-matched subjects without COM were selected at random for comparison. Risks of ICH associated with COM and comorbidities, including hypertension, diabetes, hyperlipidemia, chronic kidney disease, and drug abuse, were assessed by the end of 2010. results The incidence of ICH was 1.68 times higher in the COM cohort than in the comparison cohort, with an adjusted hazard ratio (HR) of 1.50 (95% CI 1.29-1.74) estimated in the multivariable Cox model. Age-specific analysis showed that the HR of ICH for COM patients decreased with age, with an adjusted HR of 3.28 (95% CI 1.88-5.75) in the < 40-year age group, which declined to 1.11 (95% CI 0.88-1.40) in the elderly. The incidence of ICH increased with the severity of COM; for those with severe COM the adjusted HR was 4.42 (95% CI 3.31-5.89). For subjects without comorbi...

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Section: Methods Data Sourcementioning

confidence: 99%

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

Tseng¹,

Huang²,

Muo

et al. 2015

JNS

Self Cite

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“…26 Wang et al found that women with hypertensive disorders during pregnancy were at higher of end stage renal disease than women without complicated pregnancies. 27 Thrombocytopenia was common finding in patients with hypertensive disorder of pregnancy with a mean value of platelet count among the hypertensive cases being 1.80 lacs/cumm and the mean value of the normotensive cases being 2.53 lacs/cumm. The difference between the two groups was statistically highly significant.…”

Section: 15mentioning

confidence: 99%

A comparative study of the serum levels of antiphospholipid antibodies in hypertensive disorder of pregnancy and normotensive pregnancy

Kaur

Pahwa

Kaur

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Antiphospholipid antibodies have been associated with a number of obstetric complications however their role in the pathogenesis of preeclampsia has remained uncertain Therefore, the utility of screening for antiphospholipid antibodies among women at risk for recurrent hypertensive disorder of pregnancy is still doubtful. This study is aimed to clarify relationship between hypertensive pregnancies and APLA.Methods: A prospective, randomized was conducted and, 120 patients after 20 weeks of gestation were studied. 60 patients had hypertensive disorder in pregnancy and 60 were normotensive. Blood samples were obtained from them under all asepsis, serum was separated and tested for Antiphospholipid antibodies (Anticardiolipin, anti beta 2 glycoprotein I, phosphatidyl -serine, -inositol, -ethanolamin, -choline and sphingomyelin and lupus anticoagulant), apart from other routine investigations using Aeskulsia Phospholipid-Screen-GM.Results: 4/60 and 3/60 hypertensive patients had raised IgM and IgG levels respectively. Their values came in equivocal range. 2 of the normotensive patients had equivocal range values of both IgM/IgG. Mean of IgM APLA in hypertensive and normotensive patients was 2.54 and 1.67 respectively and difference between these values was statistically non significant (p=0.081). Mean of APTT is similarly statistically non significant in two groups (p=0.817).Conclusions: No significant correlation between the hypertensive state in pregnancy and antiphospholipid antibodies, hence this test should not be recommended as a screening test in pregnancies and there was no need to assess these antibodies in the hypertensive cases of pregnancy without the history of thrombosis or autoimmune diseases.

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“…Epidemiologic studies have also shown an increased risk for end-stage renal disease (ESRD) in women with a history of preeclampsia 80,81 . Although the relative risk for ESRD in women with preeclampsia is robust with hazard ratios ranging from 4-12, the absolute risk is still quite low.…”

Section: Long-term Complications Of Preeclampsiamentioning

confidence: 99%

New Developments in the Pathogenesis of Preeclampsia

Naljayan¹,

Karumanchi²

2013

Advances in Chronic Kidney Disease

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Preeclampsia affecting 3-5% of all pregnancies is a major cause of maternal and perinatal morbidity and mortality worldwide. This disorder is characterized by a constellation of signs and symptoms, most notably new onset hypertension and proteinuria during the last trimester of pregnancy. In this review, the molecular mechanisms of preeclampsia with an emphasis on the role of circulating anti-angiogenic proteins in the pathogenesis of preeclampsia and its complications will be discussed.

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Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study

Cited by 145 publications

References 33 publications

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

Increased risk of intracerebral hemorrhage among patients with chronic osteomyelitis

A comparative study of the serum levels of antiphospholipid antibodies in hypertensive disorder of pregnancy and normotensive pregnancy

New Developments in the Pathogenesis of Preeclampsia

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