Association Between Hypertension in Healthy Participants and Zinc and Copper Status: a Population-Based Study

Darroudi, Susan; Saberi‐Karimian, Maryam; Tayefi, Maryam; Tayefi, Batool; Khashyarmanesh, Zahra; Fereydouni, Narges; Haghighi, Hamideh Moalemzadeh; Mahmoudi, Alireza; Kharazmi-Khorassani, Jasmin; Gonoodi, Kayhan; Esmaeili, Habib; Mohammadpour, Amir Hooshang; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1007/s12011-018-1518-4

Cited by 37 publications

(26 citation statements)

References 30 publications

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“…A previous study showed that zinc level is inversely associated with diastolic blood pressures while there is no association with systolic blood pressures. 24 In the current study significant increase in diastolic blood pressure was observed in the placebo arm while systolic blood pressure remained stable. Zinc supplementation reduces serum copper/ zinc ratios, which in turn reduce oxidative stress and inflammation.…”

Section: Discussionsupporting

confidence: 46%

Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)

Abeysundara

Nishad

Silva

et al. 2020

J of Cey Coll of Phy

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Section: Discussionsupporting

confidence: 46%

Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)

Abeysundara

Nishad

Silva

et al. 2020

J of Cey Coll of Phy

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“…In fact, a lower Zn level was associated with a higher level of fasting blood sugar and glycated hemoglobin [ 36 ]. In addition, previous experimental and epidemiological studies identified that certain trace elements such as Cu, Cd, and Zn may influence blood pressure and cardiovascular dysfunctions [ 37 , 38 ]. Further analysis should be extended to examine the effects of trace elements on metabolic profiles including blood pressure and blood sugar level as main outcomes.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers

et al. 2020

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This study aimed (1) to assess serum trace elements concentrations and hematological parameters, (2) to evaluate the sex differences in the associations between serum trace elements levels and hematological parameters, and (3) to identify the associations between serum trace elements concentrations and risk of anemia among Japanese community dwellers. This is a community-based cross-sectional study that utilized the data of the 2014 Iwaki Health Promotion Project. Participants were 1176 community dwellers (>18 years) residing in the Iwaki District, Aomori Prefecture, Japan. We assessed the data of serum trace elements concentrations of cadmium (Cd), cobalt (Co), copper (Cu), selenium (Se), zinc (Zn), and iron (Fe) as well as the hematological parameters of red blood cells (RBC) counts, hemoglobin, packed cells volume (PCV), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Serum concentrations of Zn (871.5 μg/L vs. 900.1 μg/L) and Fe (946.8 μg/L vs. 1096.1 μg/L) were significantly lower in females than in males, while serum concentrations of Co (0.4 μg/L vs. 0.3 μg/L) and Cu (1062.4 μg/L vs. 965.3 μg/L) were significantly higher in females. By multivariate linear regression, serum Se concentration was significantly, positively associated with PCV (β = 1.04; 95% confidence interval (CI): 0.17, 1.92; p = 0.016) among the study participants. Serum Zn also had positive associations with hemoglobin (β = 0.42; 95% CI: 0.07, 0.77; p = 0.020), PCV (β = 1.79; 95% CI: 0.78, 2.81; p < 0.001), and RBCs count (β = 15.56; 95% CI: 7.31, 31.69; p = 0.002). On the other hand, serum Co concentration was negatively associated with the hematological parameters, particularly in females. Moreover, serum Zn concentration had a decreased risk of anemia (lowest vs. highest quartiles: odds ratio (OR) = 0.42; 95% CI: 0.23, 0.76; p = 0.005) while higher Co concentrations had an increased risk of anemia (lowest vs. highest quartiles: OR = 1.95; 95% CI: 1.04, 3.67; p = 0.037). However, no significant association was found between serum Cu level and hematological parameters. There were substantial sex differences in serum trace elements, implying that trace elements metabolism differed between males and females. Zn can play a protective role in the development of anemia. Surprisingly, increased Co concentration increased the risk of anemia among our study population, which called for further studies to confirm and to consider for speciation analysis.

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“…Copper is commonly found in the liver of chicken, goat, oysters, beans, nuts, and leafy vegetables. Cu 2+ deficiency is reported in various complications like CVD, HT, and diabetic Mellitus [7,85]. Hence, the normal blood level of Cu 2+ is maintained by consuming a Cu 2+ rich diet as mentioned above at a dose of 1-1.8 mg/day (RDA).…”

Section: Copper (Cu 2+ )mentioning

confidence: 99%

“…The prevalence of HT is increasing significantly in developing and developed countries especially in major cities and towns owing to modified lifestyle (food habit and lack of exercise) and lack of proper awareness related to HT and its related co-morbid conditions [6]. Hypertension is also called as "silent killer" as it may not show any symptoms or signs (asymptomatic) especially at the beginning stage and subsequently result in life-threatening conditions (as directly connected with CVD and cerebrovascular diseases) [7]. HT is reported to alter the quality of life (increase mortality and morbidity rate) as it has a direct impact on the renalcardiovascular axis through modulating endothelial function (vascular remodeling) and renin-angiotensin-aldosterone system (RAAS).…”

Section: Introductionmentioning

confidence: 99%

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

et al. 2021

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Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular diseases (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to various diet formula (dietary approach) with a special focus on micro and macronutrients along with modified lifestyle and standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play a central role in the regulation of blood pressure (BP) as they aid the function of macronutrients and also improve the anti-hypertensive functions of some anti-hypertensive agents. Even though several studies have demonstrated the beneficial effects of micronutrients on controlling BP, still some ambiguity exists among the nutritionists/doctors, which combination or individual mineral (dietary approach) contributes to better BP regulation. Therefore, this critical review article was attempted to delineate the underlying role of micronutrients (minerals and vitamins) for the management and prevention or delaying of HT and their related complications with strong affirmation from clinical trials as well as its mechanism of controlling BP. Moreover, the major source and recommended daily allowance (RDA) of various micronutrients are included in this review for guiding common readers (especially HT subjects) and dieticians to choose/recommend a better micronutrient and their combinations (other nutrients and standard anti-hypertensive drugs) for lowering the risk of HT and its related co-morbid conditions like CVDs.

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Association Between Hypertension in Healthy Participants and Zinc and Copper Status: a Population-Based Study

Cited by 37 publications

References 30 publications

Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)

Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)

Relationship between Selected Trace Elements and Hematological Parameters among Japanese Community Dwellers

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

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