Association between hypertension in adolescents and the health risk factors of their parents: an epidemiological family study

Abstract

Hypertension in adolescence may be a predictor of cardiovascular problems in adulthood. Therefore, verification of the factors associated with this condition in adolescence is important. The aim of this study was to analyze the relationship between hypertension in adolescents with hypertension and the sociodemographic characteristics and lifestyle of their parents. This study was conducted on 1231 adolescents, 1202 mothers, and 871 fathers. The blood pressure of the adolescents was measured with an oscillometric device. Details of parental hypertension, sociodemographic characteristics, and lifestyle were obtained by self-report. The prevalence of hypertension was higher among adolescents with older fathers and older mothers, with both parents reporting hypertension and with mothers who were overweight. In multivariable analysis, adolescents with older mothers (OR = 2.36; 95% confidence interval [CI] = 1.12-4.98), hypertensive mothers (OR = 2.22 [95% CI = 1.26-3.89]), and hypertensive fathers (OR = 1.70 [95% CI = 1.03-2.81]) were more likely to have hypertension. In the analysis that considered clusters of health risk factors, higher risks of hypertension were observed in adolescents whose mothers had four or more aggregated risk factors (OR = 2.53 [95% CI = 1.11-5.74]). In conclusion, there was a relationship between hypertension in adolescents and hypertension in their parents. However, an association between hypertension in adolescents and parental age and clusters of health risk factors was only observed for their mothers.

Estatística Cardiovascular – Brasil 2021

“…Em uma análise que considerou os fatores de risco, os maiores riscos de hipertensão foram observados em adolescentes cujas mães tinham quatro ou mais fatores de risco agregados (OR 2,53; IC 95%, 1,11 - 5,74). 300 …”

“…In the analysis that considered clusters of health risk factors, higher risks of hypertension were observed in adolescents whose mothers had four or more aggregated risk factors (OR 2.53; 95% CI, 1.11 - 5.74). 300 …”

Hubungan Faktor Genetik dengan Kejadian Hipertensi: Scoping Review

“…14 Meskipun hipertensi menunjukkan heritabilitas substansial sekitar 40-60%, 5 dalam gen yang telah ditemukan, dua genom berskala besar ini mengidentifikasi varian umum di 13 lokus terkait dengan tekanan darah yang masing-masing menjelaskan hanya 0,05-0,10% varians dan hanya sekitar 1% dikaitkan dengan tekanan darah yang meningkat ketika digabungkan secara keseluruhan lokus. 15 Estimasi heritabilitas ditetapkan sebagai populasi-spesifik penekanan parameter pada dasar genetik tekanan darah. 16 Mekanisme epigenetik, termasuk metilasi DNA, mengatur transkripsi secara dinamis dan bertindak sebagai penghubung molekuler antara rangsangan lingkungan dan ekspresi gen. Semakin banyak bukti menunjukkan bahwa tingkat metilasi DNA pada sitosinfosfat spesifik Situs guanin (CpG) berhubungan dengan hipertensi.…”

“…Persentase varian tekanan darah total disebabkan oleh efek genetik yang terjadi pada hipertensi dan indeks massa tubuh sekitar 6% dan 7% untuk tekanan darah sistole dan diastole, masing-masing persentase total varian tekanan darah sistole disebabkan oleh efek genetik yang umum terjadi pada tekanan darah sistole adalah 8%. 15 Risiko hipertensi pada orang dengan riwayat keluarga jauh lebih mungkin daripada mereka yang bukan kerabat. Secara umum, dasar genetik bervariasi dari monogenik hingga poligenik menyumbang lebih dari 95%.…”

Faktor yang Berpengaruh Terhadap Kejadian Hipertensi pada Remaja di Indonesia

“…Penelitian Pardede et al di Jakarta Pusat menunjukkan riwayat hipertensi keluarga memiliki hubungan yang signifikan dengan hipertensi. 39 Hasil ini juga sesuai dengan penelitian Christofaro et al di Brazil. Remaja dengan salah satu orang tua yang mengalami hipertensi memiliki risiko lebih besar untuk mengalami hipertensi dan risiko ini meningkat pada remaja dengan kedua orang tua yang mengalami hipertensi.…”