Association Between Hypertension and Incident Infective Endocarditis

Lee, Gyu Bae; Shin, Koh Eun; Han, Kyungdo; Son, Hong-Seok; Jung, Jae Seung; Kim, Yang Hyun; Kim, H. J.

doi:10.1161/hypertensionaha.122.19185

Cited by 2 publications

(1 citation statement)

References 30 publications

(43 reference statements)

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“…In a recent publication using national cohort data, Lee et al demonstrated that increased blood pressure was associated with an increased risk for IE in dose-dependent manner. (12) In line with it, our study showed that HTN was an independent predictor of incident IE in the diabetic cohort as well. However, unlike DM which is known to cause immune dysfunction, angiopathy, or gastrointestinal and urinary dysmotility, the mechanism by which HTN causes incident IE is still unclear.…”

Section: Discussionsupporting

confidence: 80%

The risk of infective endocarditis according to blood pressure in patients with diabetes: a nationwide population-based study

Pyo,

Kim,

Kim

et al. 2023

Preprint

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Background We aimed to assess the incidence of infective endocarditis (IE) and evaluate the impact of hypertension (HTN) with underweight on the risk of IE among patients with diabetic mellitus (DM) using a nationwide population-based cohort in Korea. Methods We identified 2,603,012 participants (57.4 ± 12.3 years) in the national health insurance database. Of these, 374,586 were normotensive, 750,006 were at pre-HTN status, and the remainder had HTN. The risk of IE was compared between the groups, and the impact of being underweight (body mass index < 18.5) was also evaluated. Results During follow-up (7.14 years; interquartile range 6.01–8.08 years), 1,703 cases of IE occurred; 168 (0.0647 person per 1000 person-years [PY]), 303 (0.05836 per 1000 PY), and 1,232 (0.12235 per 1000 PY) in normotensive, pre-HTN and HTN group, respectively. Hypertensive participants presented a higher risk of IE (hazard ratio, 1.360; 95% confidence interval, 1.152–1.607) than normotensive participants. Being underweight increased the risk of IE by 90% among subjects with HTN. In subgroup analysis, age, duration of DM, insulin use, and habitual factors were not associated with the incidence of IE. Conclusions Diabetic patients may require rigorous blood pressure control and simultaneous avoidance of excessive weight loss to prevent IE.

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Section: Discussionsupporting

confidence: 80%

The risk of infective endocarditis according to blood pressure in patients with diabetes: a nationwide population-based study

Pyo,

Kim,

Kim

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Spatiotemporal patterns of rheumatic heart disease burden attributable to high systolic blood pressure, high sodium diet, and lead exposure (1990 to 2019): a longitudinal observational study

Zhang,

Liu

et al. 2024

Front. Nutr.

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BackgroundRheumatic heart disease (RHD) continues to be a significant global health concern, exhibiting unique regional disparities. Although there is a noted decline in the burden of RHD, the specific causatives for this decrease remain unclear. This study aims to identify and quantify the spatiotemporal patterns related to the RHD-attributable risk burden.MethodsThe data pertaining to deaths and disability-adjusted life years (DALYs) attributable to RHD risk were drawn from the Global Burden of Disease (GBD) study conducted from 1990 to 2019. These data, categorized by age, gender, and geographical location, highlighted risk factors including diets high in sodium, elevated systolic blood pressure (SBP), and lead exposure. To examine the long-term trends in RHD changes due to these specific risk factors, the average annual percentage change (AAPC) method was used.ResultsDuring the past 30 years, the highest decrease in RHD burden was attributed to high SBP. An AAPC of −2.73 [95% confidence interval (CI): −2.82 to −2.65] and − 2.45 (95% CI: −2.55 to −2.36) in deaths and DALYs was attributable to high SBP, while an AAPC of −3.99 (95% CI: −4.14 to −3.85) and − 3.74 (95% CI: −3.89 to −3.6) in deaths and DALYs was attributed to a diet high in sodium. Moreover, the trends in deaths and DALYs due to lead exposure also showed decreases with an AAPC of −2.94 (95% CI: −3 to −2.89) and − 3.46 (95% CI: −3.58 to −3.34) from 1990 to 2019. Oceania showed an upward trend of the RHD DALYs due to high SBP, with an AAPC of 0.23 (95% CI: 0.13 to 0.33). In general, countries in Oceania, East Asia, and South Asia had higher age-standard deaths and DALY rates of RHD due to diets high in sodium.ConclusionOur study has revealed that high SBP remains the prime risk factor contributing to the RHD burden. There are decreasing spatiotemporal patterns in RHD-related deaths and burdens. Gaining this knowledge is fundamental to making informed public health strategies and clinical decisions, especially concerning risk assessment, screening, and prevention initiatives.

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Association Between Hypertension and Incident Infective Endocarditis

Cited by 2 publications

References 30 publications

The risk of infective endocarditis according to blood pressure in patients with diabetes: a nationwide population-based study

The risk of infective endocarditis according to blood pressure in patients with diabetes: a nationwide population-based study

Spatiotemporal patterns of rheumatic heart disease burden attributable to high systolic blood pressure, high sodium diet, and lead exposure (1990 to 2019): a longitudinal observational study

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