Association between hydrogen sulfide and OSA-associated hypertension: a clinical study

Shi, Man-Man; Wang, Jianli; Zhang, Liqiang; Qin, Mei; Huang, Yongle

doi:10.1007/s11325-019-01997-y

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…26 Multivariate linear regression analysis of patients with hypertension with obstructive sleep apnea revealed a negative correlation between higher 24-hour systolic and diastolic blood pressure and lower serum H 2 S levels compared with those in normotensive people. 27 Furthermore, a clinical trial with 126 patients with hypertension showed that N-acetylcysteine (NAC) as an H 2 S precursor significantly decreased systolic and diastolic blood pressures. 28 Kidney diseases and hypertension are intertwined, with both conditions influencing each other as primary disorders and secondary outcomes.…”

Section: So What? H 2 S and Hypertension Pathology Systemic Hypertensionmentioning

confidence: 99%

Roles of Hydrogen Sulfide in Hypertension Development and Its Complications: What, So What, Now What

Wang

2023

Hypertension

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Hypertension is a multicause health challenge, and hydrogen sulfide (H 2 S) is a multifunctional gasotransmitter. A critical pathologic role of endogenous H 2 S deficiency in the development of hypertension was established 15 years ago based on animal studies, setting the stage for examining the wide spectrum of cardiovascular effects and the underlying molecular and cellular mechanisms of H 2 S. We are also starting to gain a better understanding of the role of altered H 2 S metabolism in human hypertension. The purpose of this article is to examine our current understanding of the roles played by H 2 S in the development of hypertension in both animals and humans. Additionally, H 2 S-based antihypertension therapeutic strategies are reviewed. Is H 2 S at the root of hypertension and one of the solutions for the same? The probability is very high.

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Section: So What? H 2 S and Hypertension Pathology Systemic Hypertensionmentioning

confidence: 99%

Roles of Hydrogen Sulfide in Hypertension Development and Its Complications: What, So What, Now What

Wang

2023

Hypertension

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“…However, the change of H 2 S concentration has been reported to be reduced in high blood pressure (HBP) patients, suggesting the potential regulatory role of H 2 S in HBP ( 11 , 12 ). Several clinical studies have reported the relationship between H 2 S and hypertension related disorders ( 13 ). Additionally, decreased H 2 S plasmatic levels were also found in lead-induced HBP patients ( 14 ).…”

Section: Endogenous H 2 S In Hypertensionmentioning

confidence: 99%

Hydrogen sulfide: A new therapeutic target in vascular diseases

Zhu

Liu

et al. 2022

Front. Endocrinol.

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Hydrogen sulfide (H2S) is one of most important gas transmitters. H2S modulates many physiological and pathological processes such as inflammation, oxidative stress and cell apoptosis that play a critical role in vascular function. Recently, solid evidence show that H2S is closely associated to various vascular diseases. However, specific function of H2S remains unclear. Therefore, in this review we systemically summarized the role of H2S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. In addition, this review also outlined a novel therapeutic perspective comprising crosstalk between H2S and smooth muscle cell function. Therefore, this review may provide new insight inH2S application clinically.

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Hydrogen Sulfide in Inflammation: A Novel Mediator and Therapeutic Target

Bhatia

Gaddam

2021

Antioxidants & Redox Signaling

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Association between hydrogen sulfide and OSA-associated hypertension: a clinical study

Cited by 3 publications

References 21 publications

Roles of Hydrogen Sulfide in Hypertension Development and Its Complications: What, So What, Now What

Roles of Hydrogen Sulfide in Hypertension Development and Its Complications: What, So What, Now What

Hydrogen sulfide: A new therapeutic target in vascular diseases

Hydrogen Sulfide in Inflammation: A Novel Mediator and Therapeutic Target

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