Association between humidifier disinfectant exposure during infancy and subsequent neuropsychiatric outcomes during childhood: a nation-wide cross-sectional study

Abstract

Background The purpose was to determine the association between infant exposure to humidifier disinfectant (HD) with neuropsychiatric problems in pre-school children. Methods A total of 2,150 children (age 4–11 months) were enrolled in the Panel Study of Korean Children (PSKC) study. The Korean version of the Child Behavior Checklist (CBCL) was used for assessments of neuropsychiatric problems. 1,113 children who participated in all the first to third PSKC studies and answered a question about HD exposure were finally enrolled. Results There were 717 (64.5%) children in non-HD group who were not exposed to HD and 396 (35.5%) in HD group with former exposure to HD. Exposure to HD was associated with total neuropsychiatric problems (adjusted odds ratio, aOR = 1.54, 95% CI = 1.15–2.06), being emotionally reactive (aOR = 1.55, 95% CI = 1.00–2.39), having attention problems (aOR = 1.96, 95% CI = 1.10–3.47), having oppositional defiant problems (aOR = 1.70, 95% CI = 1.07–2.71), and having attention deficit/hyperactivity problems (aOR = 11.57, 95% CI = 1.03–2.38). The risks for neuropsychiatric problems were clearly increased in boy, firstborn, and secondary smoker. Conclusions Exposure to HD during early childhood had a potential association with subsequent behavioral abnormalities.

Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration

“…For group 1, studies published on humans, a total of 49 articles were selected ( Table 2 ). 1 2 3 4 5 6 7 9 10 11 12 13 14 17 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 The suspicion that humidifier disinfectant might be a cause of lung damage was suggested in 2011. Studies in international journals began to appear in 2013.…”

“…Case reports, panel survey-based studies, and cross-sectional studies have been conducted on the damage to the neuropsychiatric system in cases of non-respiratory damage. 36 37 38 …”

A Study on the Preliminary Plan for Environmental Health in Seoul, Korea

“…Among them, 62% were aged less than eight years old and 31.7% were pregnant women [ 27 ]. Furthermore, exposure to HD during infancy is potentially associated with subsequent behavioral abnormality [ 28 ]. In the Republic of Korea, the total volume of chemicals distributed and the number of chemical species is constantly increasing.…”