Association between human α 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women

Kim, Jung Gu; Kim, Hoon; Ku, Seung Yup; Kim, Seok Hyun; Choi, Young Min; Moon, Shin Yong

doi:10.1016/j.fertnstert.2004.05.089

Cited by 23 publications

(7 citation statements)

References 20 publications

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“…α2-HS glycoprotein (AHSG) has been implicated in tissue development, and polymorphisms in the AHSG gene (p.T230M and p.T238S) have been linked to endometriosis susceptibility in Korean women (Kim et al ., 2004). The plasminogen activator inhibitor 1 (PAI-1) 4G/5G promoter polymorphism has been investigated in 75 women with laparoscopically confirmed endometriosis and 43 controls (Bedaiwy et al ., 2006).…”

Section: Resultsmentioning

confidence: 99%

Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis

Tempfer

Simoni

Destenaves

et al. 2008

Human Reproduction Update

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BACKGROUNDEndometriosis has a strong genetic component, and numerous genetic studies have been reported.METHODSWe have systematically reviewed these studies and included 114 in our final selection.RESULTSWe found no consistent evidence linking endometriosis with specific polymorphisms in genes encoding inflammatory mediators, proteins involved in sex steroid metabolism, vascular function and tissue remodelling. Although a number of polymorphisms have been associated with endometriosis in selected populations, the associations have not been independently confirmed, either because only single studies were carried out on these markers/genes or because other studies reported no association. The most solid evidence linking specific polymorphisms to endometriosis came from studies investigating glutathione-S-transferase, a phase II detoxification enzyme. Carriage of the GSTT1 null deletion variant showed consistent association with endometriosis with a 29% increased risk; however, it cannot be excluded that this result was due to publication bias, and this association should be independently confirmed in large-scale, well-designed case–control studies.CONCLUSIONSThe evidence of an association between genetic polymorphisms and endometriosis is weak. Carriage of the GSTT1 null deletion may moderately increase the risk of this disease. We suggest that the methodology of association studies should be improved in order to identify and validate associations in endometriosis.

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Section: Resultsmentioning

confidence: 99%

Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis

Tempfer

Simoni

Destenaves

et al. 2008

Human Reproduction Update

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“…Careful monitoring is necessary for pregnant women with DOR. In the future, possible underlying molecular mechanisms313233343536 in animal models37383940 should also be explored.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy afterIn VitroFertilization and Embryo Transfer

Kim

Shin

et al. 2019

Yonsei Med J

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Purpose To elucidate the correlation between ovarian reserve and the incidence of ectopic pregnancy (EP) following in vitro fertilization and embryo transfer (IVF/ET) cycles. Materials and Methods In this observational study, 430 fresh IVF/ET cycles were examined from patient data of two university hospital infertility clinics. All included patients were positive for β-human chorionic gonadotropin (hCG) at 2 weeks after oocyte retrieval via controlled ovarian stimulation. For each cycle, information on age, duration of infertility, basal follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), days of ovarian stimulation, numbers of retrieved oocytes and transferred embryos, and pregnancy outcomes was collected. Patients with AMH lower than 1.0 ng/dL or basal FSH higher than 10 mIU/mL were classified into the decreased ovarian reserve (DOR) group, and the remaining patients were classified into the normal ovarian reserve (NOR) group. Results In total, 355 cycles showed NOR, and 75 cycles DOR. There were no significant differences between the DOR and NOR groups regarding intrauterine (74.7% vs. 83.4%, respectively) or chemical (14.7% vs. 14.1%, respectively) pregnancies. The DOR group had a higher EP than that of NOR group [10.7% (8/75) vs. 2.5% (9/355), p =0.004]. In both univariate [odds ratio (OR) 5.6, 95% confidence interval (CI) 1.4–9.6, p =0.011] and multivariate (adjusted OR 5.1, 95 % CI 1.1–18.7, p =0.012) analysis, DOR was associated with a higher risk of EP. Conclusion DOR may be associated with a higher risk of EP in IVF/ET cycles with controlled ovarian stimulation. More careful monitoring may be necessary for pregnant women with DOR.

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“…The population distribution of these three genotypes varies globally. The available data from several surveys demonstrate that AHSG*1 is in frequency the foremost fetuin genotype (19–21). For example, the distribution of AHSG*1, AHSG1/2 and AHSG*2 in 697 unrelated Italians was found to be around 0.56:0.36:0.08 (22).…”

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confidence: 99%

Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein

Lin

Zhu

Meijer

et al. 2019

Molecular & Cellular Proteomics

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Lin et al . applied a hybrid mass spectrometric approach to fully characterize fetuin purified from 20 individuals - 10 healthy donors and 10 septic patient donors. The results reveal that frequent genetic polymorphism influences the glycosylation pattern of fetuin. Next, the site-specific characterization of posttranslational modifications on all purified fetuins allowed to classify individuals by genotype and also disease state (i.e. sepsis). These findings provide an interesting example of glycoproteogenomics, e.g. how gene polymorphism may affect glycosylation profiles.

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Association between human α 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women

Cited by 23 publications

References 20 publications

Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis

Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis

Correlation between Ovarian Reserve and Incidence of Ectopic Pregnancy afterIn VitroFertilization and Embryo Transfer

Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein

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