Association between human papillomavirus and endometrial adenocarcinoma

Karadayi, Nimet; Geçer, Melin Özgün; Kayahan, Sibel; Yamuc, Elif; Onak, Nilüfer; Korkmaz, Taner; Yavuzer, Dilek

doi:10.1007/s12032-013-0597-5

Cited by 14 publications

(17 citation statements)

References 28 publications

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“…Intestinal differentiation has been described in a mucinous endometrial adenocarcinoma (18) but HPV is thought not to be causally associated with endometrial neoplasia (3,19,20). The morphology and immunoprofile of the intestinal glands in our case are identical to those of the endocervical AIS, and HPV 31 was detected in both the polyp and the endocervical biopsy material.…”

Section: Discussionsupporting

confidence: 53%

Endocervical Adenocarcinoma In Situ Presenting in Fundal Endometrial Polyp

Roberts

Cornall

Lamaro

et al. 2015

International Journal of Gynecological Pathology

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A 38-yr-old woman, with a previous history of low grade squamous intraepithelial lesion in the cervix, presented with heavy menstrual bleeding. At hysteroscopy, a fundal polyp was removed from the right cornu which displayed many glands lined by atypical, mitotically active epithelium with features characteristic of endocervical adenocarcinoma in situ (AIS) of intestinal subtype. Subsequent cervical liquid-based cytology and colposcopically directed biopsies revealed no causative lesion, but residual PreservCyt from the ThinPrep vial tested positive for high risk HPV type other than HPV 16 and 18. Further biopsies from the endocervical canal and base of the resected polyp showed intestinal type AIS, while all those from the intervening anterior and posterior endometrial lining exhibited normal endometrium only. Genomic DNA extracted from the endometrial polyp and second set of endocervical biopsies tested positive for HPV 31, an uncommon cause of endocervical glandular neoplasia. Endocervical AIS typically arises in the transformation zone but may be found exclusively in the endocervical canal and rarely as high as 30 mm from the ectocervix. Contiguous spread into the lower uterine segment is known to occur, as are proximate so-called skip lesions. However, finding a 'skip' lesion 80 mm from the transformation zone poses an interesting pathogenetic conundrum as well as a therapeutic dilemma in a young patient desirous of retaining fertility. Issues relating to pathogenesis include necessary metaplasia of the endometrial glandular epithelium to 'susceptible' endocervical type epithelium within the polyp or metastatic implantation of transformed endocervical glandular cells onto the polyp. The current management plan involves regular hysteroscopic surveillance of the uterine cavity.

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Section: Discussionsupporting

confidence: 53%

Endocervical Adenocarcinoma In Situ Presenting in Fundal Endometrial Polyp

Roberts

Cornall

Lamaro

et al. 2015

International Journal of Gynecological Pathology

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“…21Y23 It was also reported that HPV is one of the causative factors of squamous differentiation in the endometrium. 24,25 We applied whole exome sequencing to investigate the molecular profile of a low-grade endometrioid carcinoma, as well as of a lung metastasis, in a female patient. The primary and metastatic tumors shared some of the mutations, and GO analysis showed an enrichment on cellular response to estradiol stimulus, indicating that the lung metastasis indeed origins from the primary endometrium tumor.…”

Section: Discussionmentioning

confidence: 99%

Possible Risk Factors of Pulmonary Metastases in Patients With International Federation of Gynecology and Obstetrics Stage I Endometrioid-Type Endometrial Cancer

Jiang

Tao

Huang

et al. 2017

Int J Gynecol Cancer

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“…7 Furthermore, cervical HPV infection impairs the physiological protective capacity of the uterine cervix. 30 Studies employing in situ hybridization have detected HPV DNA in non-neoplastic endometrium in 19.6 31 and 60% 32 of biopsies. It is possible that initial infection of the endometrium is facilitated by regular menstrual shedding (akin to wounding), whereas the lack of menstrual shedding, endometrial decidualisation, and immune suppression during pregnancy contributes to HPV persistence and growth.…”

Section: Discussionmentioning

confidence: 99%

“…HPV DNA was detected using the GenPoint HPV DNA Probe cocktail (identifies 13 high-risk HPV types: 16,18,31,33,35,39,45,51,52,56,58,59, and 68) and the GenPoint Tyramide Signal Amplification system according to the manufacturer's instructions with one modification (the biotinyl tyramide solution was added to each slide for five instead of 15 min) (Dako, Glostrup, Denmark). Cells were imaged using light microscopy.…”

Section: Chromogenic In Situ Hybridization (Cish)mentioning

confidence: 99%

“…12 HPV DNA has been detected in the placenta and amniotic fluid. 7,11,[14][15][16][17]11,16,18,and 31 have been shown to replicate in trophoblast cell lines, [18][19][20] where HPV infection decreased trophoblast number and trophoblast-endometrial cell adhesion in vitro. 19,20 We investigated for the presence of HPV in the placenta and carried out a histopathological and molecular cross-sectional study of 339 placentae from complicated and uncomplicated pregnancies.…”

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confidence: 99%

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A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications

et al. 2015

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Viral infections are known to adversely affect pregnancy, but scant attention has been given to human papilloma virus (HPV) infection. We aimed to determine the molecular and histopathological features of placental HPV infection, in association with pregnancy complications including fetal growth restriction, pre-maturity, pre-eclampsia, and diabetes. Three hundred and thirty-nine placentae were selected based on the presence or absence of pregnancy complications. Five independent methods were used to identify HPV in the placenta, namely, immunohistochemistry for L1 viral capsid, in situ hybridization to high-risk HPV DNA, PCR, western blotting, and transmission electron microscopy. Pregnancy complications and uterine cervical smear screening results were correlated with placental HPV histopathology. In this study, which was deliberately biased towards complications, HPV was found in the decidua of 75% of placentae (253/339) and was statistically associated with histological acute chorioamnionitis (P o0.05). In 14% (35/253) of the HPV positive cases, HPV L1 immunoreactivity also occurred in the villous trophoblast where it was associated with a lymphohistiocytic villitis (HPV-LHV), and was exclusively of high-risk HPV type. HPV-LHV significantly associated with fetal growth restriction, preterm delivery, and pre-eclampsia (all P o0.05). All cases of pre-eclampsia (20/20) in our cohort had high-risk placental HPV. A further 55 cases (22%, 55/253) of HPV positive placentae had minimal villous trophoblast HPV L1 immunoreactivity, but a sclerosing pauci-immune villitis, statistically associated with diabetes (49.1%, 27/55, Po 0.05). For women with placental HPV, 33% (69/207) had an HPV-related positive smear result before pregnancy compared with (9.4% 8/85) of women with HPV-negative placentae (P = 0.0001). Our findings support further investigations to determine if vaccination of women and men will improve pregnancy outcomes. Modern Pathology (2015Pathology ( ) 28, 1369Pathology ( -1382 doi:10.1038/modpathol.2015 published online 21 August 2015 In the immune and hormonal modulated milieu of pregnancy, viruses are well known to infect the placenta, developing fetus, and neonate. The most common and important neoplastic driver of the lower uterine tract, human papillomavirus (HPV), 1 has been detected in the uterine cervix of 15-25% of pregnant women 2-6 and a cervical HPV infection during pregnancy has been associated with a higher incidence of spontaneous abortions, 7-9 premature rupture of the membranes, 10 spontaneous preterm labor, 11,12 pre-eclampsia, 13 and placental 'villitis' not otherwise specified. 12 HPV DNA has been detected in the placenta and amniotic fluid. 7,11,[14][15][16][17]11,16,18,and 31 have been shown to replicate in trophoblast cell lines, [18][19][20] where HPV infection decreased trophoblast number and trophoblast-endometrial cell adhesion in vitro. 19,20 We investigated for the presence of HPV in the placenta and carried out a histopathological and molecular cross-sectional study of 339 ...

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Association between human papillomavirus and endometrial adenocarcinoma

Cited by 14 publications

References 28 publications

Endocervical Adenocarcinoma In Situ Presenting in Fundal Endometrial Polyp

Endocervical Adenocarcinoma In Situ Presenting in Fundal Endometrial Polyp

Possible Risk Factors of Pulmonary Metastases in Patients With International Federation of Gynecology and Obstetrics Stage I Endometrioid-Type Endometrial Cancer

A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications

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