Association between human herpesviruses and multiple sclerosis: A systematic review and meta-analysis

Khalesi, Zohreh; Tamrchi, Vahid; Razizadeh, Mohammad Hossein; Letafati, Arash; Moradi, Pouya; Habibi, Arezoo; Habibi, Negar; Heidari, Jafar; Noori, Maryam; Samiei, Mahboubeh Nahid; Azarash, Ziba; Hoseini, Mahdiyeh; Saadati, Hassan; Bahavar, Atefeh; Farajzade, Maryam; Saeb, Sepideh; Hadadi, Mohammad; Majd, Mahdieh Sorouri; Mothlaghzadeh, Saeed; Fazli, Paria; Asgari, Katayoon; Kiani, Seyed Jalal; Ghorbani, Saied

doi:10.1016/j.micpath.2023.106031

Cited by 22 publications

(17 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HSV-1 has been reported to be the most common cause of infectious blindness and fatal encephalitis worldwide. It can also cause Bell's palsy when it infects the facial nerve, an acute spontaneous facial paralysis that accounts for 50–70% of all peripheral facial paralysis (Imafuku, 2023 ; Khalesi et al, 2023 ). Reactivation of latent HSV-1 infection in the geniculate ganglion is considered a major cause of Bell's palsy.…”

Section: Introductionmentioning

confidence: 99%

“…The virus can then migrate to the sensory ganglia and enter the latent stage, preventing clearance by the immune system (McQuillan et al, 2018). In brief, HSV-1 infection begins with primary infection in the periphery, followed by lifelong latency in the peripheral nervous system, which can cause various clinical signs and symptoms, such as skin lesions, acute retinal necrosis, genital sores, and other pathologies (Khalesi et al, 2023). Furthermore, HSV-1 can cause fatal systemic infections or encephalitis, problems typically most associated with immune naive or immunocompromised patients (Imafuku, 2023).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

Guo

Tan

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Herpes simplex virus 1 (HSV-1) is a widely distributed virus. HSV-1 is a growing public health concern due to the emergence of drug-resistant strains and the current lack of a clinically specific drug for treatment. In recent years, increasing attention has been paid to the development of peptide antivirals. Natural host-defense peptides which have uniquely evolved to protect the host have been reported to have antiviral properties. Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all vertebrate species and play a vital role in the immune system. In this study, we demonstrated the anti-HSV-1 effect of an antiviral peptide named WL-1 derived from human cathelicidin. We found that WL-1 inhibited HSV-1 infection in epithelial and neuronal cells. Furthermore, the administration of WL-1 improved the survival rate and reduced viral load and inflammation during HSV-1 infection via ocular scarification. Moreover, facial nerve dysfunction, involving the abnormal blink reflex, nose position, and vibrissae movement, and pathological injury were prevented when HSV-1 ear inoculation-infected mice were treated with WL-1. Together, our findings demonstrate that WL-1 may be a potential novel antiviral agent against HSV-1 infection-induced facial palsy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

Guo

Tan

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Also, the relationship between VZV and MS appears to be generally consistent in the most recent meta‐analyses. The MS process was reported to have been greatly improved by the VZV in Khaleesi, Rice, and Lasa 23,29,30 …”

Section: Discussionmentioning

confidence: 99%

“…74 Their findings did not support an association between HSV-1 immunoglobulin G (IgG) levels and MS risk nor imply a causative role for HSV-2 IgG. 75 In contrast, the latest evidence confirms that prior HSV-1 infection can be associated with the onset of paediatric MS. Also, a previous HSV-2 infection may have a crucial impact on the onset of MS. 26 The most recent research confirms that previous HSV-1 infection has been linked to paediatric MS. Additionally, prior HSV-2 infection is associated with the onset of MS. 26,29 Investigation of HSV-1 and MS in adolescents may help clarify the issue.…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

The association between various viral infections and multiple sclerosis: An umbrella review on systematic review and meta‐analysis

Bakhshi,

Eslami,

Norouzi

et al. 2023

Reviews in Medical Virology

View full text Add to dashboard Cite

Multiple Sclerosis (MS) is one of the immune‐mediated demyelinating disorders. Multiple components, including the environment and genetics, are possible factors in the pathogenesis of MS. Also, it can be said that infections are a key component of the host's response to MS development. Finally, we evaluated the relationship between different pathogens and MS disease in this umbrella research. We systematically collected and analysed multiple meta‐analyses focused on one particular topic. We utilised the Scopus, PubMed, and Web of Science databases starting with inception until 30 May 2023. The methodological quality of the analysed meta‐analysis has been determined based on Assessing the Methodological Quality of Systematic Reviews 2 and Grade, and graph construction and statistical analysis were conducted using Comprehensive Meta‐Analysis. The Confidence Interval of effect size was 95% in meta‐analyses, and p < 0.05 indicated a statistically meaningful relationship. The included studies evaluated the association between MS and 12 viruses containing SARS‐CoV‐2, Epstein–Barr virus (EBV), Hepatitis B virus, varicella–zoster virus (VZV), human herpesvirus 6 (HHV‐6), HHV‐7, HHV‐8, HSV‐1, HSV‐2, Cytomegalovirus, Human Papillomavirus, and influenza. SARS‐CoV‐2, with a 3.74 odds ratio, has a significantly more potent negative effect on MS among viral infections. After that, EBV, HHV‐6, HSV‐2, and VZV, respectively, with 3.33, 2.81, 1.76, and 1.72 odds ratios, had a significantly negative relationship with MS (p < 0.05). Although the theoretical evidence mostly indicates that EBV has the greatest effect on MS, recent epidemiological studies have challenged this conclusion and put forward possibilities that SARS‐CoV‐2 is the culprit. Hence, it was necessary to investigate the effects of SARS‐CoV‐2 and EBV on MS.

show abstract

“…The complex etiology of MS, which includes multiple environmental and genetic factors, was recognized [ 2 ] and the progress in understanding and treating MS have been made during previous decade. Advancements in molecular methodologies have pointed to a number of associated genetic and epigenetic mechanisms [ 3 ] and infectious factors [ 4 ] that may contribute to MS onset and progression. Recently, a number of genetic variants (single nucleotide polymorphisms, SNPs) associated with MS risk have been mapped [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Expression levels of GSDMB and ORMDL3 are associated with relapsing-remitting multiple sclerosis and IKZF3 rs12946510 variant

Stefanović,

Stojković,

Životić

et al. 2024

Heliyon

View full text Add to dashboard Cite

Association between human herpesviruses and multiple sclerosis: A systematic review and meta-analysis

Cited by 22 publications

References 24 publications

Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

Cathelicidin-derived antiviral peptide inhibits herpes simplex virus 1 infection

The association between various viral infections and multiple sclerosis: An umbrella review on systematic review and meta‐analysis

Expression levels of GSDMB and ORMDL3 are associated with relapsing-remitting multiple sclerosis and IKZF3 rs12946510 variant

Contact Info

Product

Resources

About