Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital

Abstract

Background House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines. Results The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017. Conclusions HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms. Trial registration ClinicalTrial.gov, NCT04958616.

Detection Of Treatment Adherence, Disease Control and Its Predictors in Asthma Patients by Rural Community Level Health Workers

“…10 House-dust was proven to be associated with asthma in our study as also various guidelines on immunotherapy in Asthma. 11 As per the study on children done by Okasha et al, 12 sensitisation to house dust mite increased asthma severity and decreased the ability to control symptoms. Thereby it is imperative that, physicians may adopt a pragmatic approach house-dust and mite contact avoidance and to advise sensitized patients to implement feasible set of measures for reduction in exposure to them as much as possible.…”

Modular assembly of bioprinted perfusable blood vessel and tracheal epithelium for studying inflammatory respiratory diseases

“…People are exposed to the house dust mite very frequently in daily life. Many asthma patients have been exacerbated by the house dust mite [44,45]. Therefore, the HDME was added to the asthma model induced by IL-13 to implement an asthma exacerbation model.…”

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“…Various studies have provided evidence that sulfate (SO₄ 2 -), ammonium (NH₄⁺), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), particle matter (PM10 and PM2.5), and ozone (O 3 ) exposure in asthmatic patients were associated with decreased PEF levels, ( Edginton et al, 2021 ; Kim et al, 2021a ; Gehring et al, 2020 ). Additionally, the existing biological hazards in air pollutants such as mites have previously been reported to reduce PEF levels because of their allergy sensitization ( Okasha et al, 2021 ). However, the vivid mechanism remains unclear and needs to be addressed.…”