Association between HLA Variations and Chronic Hepatitis B Virus Infection in Saudi Arabian Patients

Al‐Qahtani, Ahmed; Al-Anazi, Mashael R.; Abdo, Ayman A.; Sanai, Faisal M.; Al–Hamoudi, Waleed; Alswat, Khalid; Al-Ashgar, Hamad I.; Khalaf, Nisreen; Eldali, Abdelmoneim; Viswan, Nisha A.; Al-Ahdal, Mohammed N.

doi:10.1371/journal.pone.0080445

Cited by 50 publications

(80 citation statements)

References 29 publications

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“…After reviewing all full texts ascertained from these publications, nine articles were excluded because two did not mention the association between the SNPs and HCC, six did not provide frequencies of alleles or genotypes, and one article did not mentioned the two SNPs under investigation. Five articles containing information on rs3077 and rs9277535 polymorphisms and HCC susceptibility were identified Hu et al, 2012;Al-Qahtani et al, 2014;Posuwan et al, 2014). The flow diagram of the study selection process is shown in Figure 1.…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…The SNPs rs3077 and rs9277535 of HLA-DP have been reported to be associated with the persistence of HBV infection and with spontaneous HBV clearance (Guo et al, 2011;Cheng et al, 2013;Hu et al, 2013). Recently, a relationship between the HLA-DP gene and HCC susceptibility has been reported by multiple labs, but the results have been discordant Li et al, 2011;Hu et al, 2012;Chen et al, 2013;Al-Qahtani et al, 2014;Posuwan et al, 2014). Therefore, in order to clarify the role of HLA-DP polymorphisms in HCC susceptibility, a systematic review and meta-analysis of published data were carried out in this study.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Zhang

Zheng

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out using the PubMed and Google Scholar databases. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated for HLA-DP alleles, and for co-dominant, dominant, and recessive genotype models of each SNP, based on fixed-or randomeffects models. A total of nine studies from six published articles were included. The association study between rs3077 and HCC susceptibility was performed in four independent comparisons that contained 1871 cases with hepatitis B virus (HBV)-related HCC and 3207 carriers with (2015) persistent HBV. Association between rs9277535 and HCC susceptibility was examined in five separate comparisons that contained 2017 cases and 3930 carriers. Our analysis indicated a significant association of rs3077 and rs9277535 with HCC susceptibility, suggesting that rs3077 might act beneficially against HCC susceptibility (A vs G: OR = 0.884, 95%CI = 0.803-0.973, P = 0.012; GA vs GG: OR = 0.842, 95%CI = 0.733-0.967, P = 0.015; AA+GA vs GG: OR = 0.848, 95%CI = 0.744-0.968, P = 0.014), and that rs9277535 might promote HCC susceptibility (AA vs GA: OR = 1.202, 95%CI = 1.011-1.428, P = 0.037). This study suggested that HLA-DP rs3077 and rs9277535 polymorphisms are associated with HCC susceptibility in the Asian population.

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Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Zhang

Zheng

et al. 2015

Genet. Mol. Res.

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“…Several studies, especially analyzing Asian samples, found association between the SNP rs9277535 and chronic HBV infection (Kamatani et al, 2009;Lau et al, 2011;Mbarek et al, 2011;Png et al, 2011;Nishida et al, 2012;Yan et al, 2012;Kim et al, 2013;Al-Qahtani et al, 2014;Chang et al, 2014;Liao et al, 2014;Pan et al, 2014;He et al, 2015;Yu et al, 2015). Additionally, the study conducted by Thomas et al (2012) found an association between the SNP rs9277535 and the elimination rate of HBV in patients EuroAmerican and African-Americans (P = 0.0001).…”

Section: Discussionmentioning

confidence: 98%

“…In the study conducted by O'Brien et al (2011), the SNP rs9277535 was associated with a reduction in HLA-DPB1 gene expression in European patients. In Asian studies, the SNP rs7453920 was associated with the immune response to HBV (Mbarek et al, 2011;Al-Qahtani et al, 2014;Liao et al, 2014;He et al, 2015). However, no studies have associated this SNP in samples from other regions of the world.…”

Section: Discussionmentioning

confidence: 99%

“…Recent genome-wide association studies (GWAS) have demonstrated two single nucleotide polymorphisms (SNPs) located in the genes HLA-DPB1 (rs9277535, A/G) and HLA-DQB2 (rs7453920, A/G). Both are associated with the persistence of HBV infection, mainly in Asian populations (Kamatani et al, 2009;Mbarek et al, 2011;Wong et al, 2013;Al-Qahtani et al, 2014). These SNPs result in an A to G transition in two different gene regions: rs9277535 in the 3'-untranslated region (3'-UTR) of the HLA-DPB1 gene and rs7453920 in the intron 1 of the HLA-DQB2 gene.…”

Section: Introductionmentioning

confidence: 99%

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Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population

Pereira¹,

Wolf²,

Stumm³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations in the human leukocyte antigen (HLA) class II (HLA-DPB1 and HLA-DQB2 genes) are related to the chronic HBV infection. This study aimed to investigate the association of two single nucleotide polymorphism (SNPs), one in the HLA-DPB1 (rs9277535) and one in the HLA-DQB2 (rs7453920), with chronic hepatitis B infection in a southern Brazilian sample. This case-control study included 260 HBV patients attended in a Specialized 2 V.R.Z.B. Pereira et al. Genetics and Molecular Research 16 (2): gmr16029565Center for Health in Caxias do Sul (Brazil) between 2014 and 2016. The same number of controls (matching for age, gender, and ethnicity) was obtained in a University Hospital in the same city and period. Blood samples were collected and genomic DNA was extracted. Genotyping were performed by real-time Taqman PCR method. Odds ratios with 95% confidence intervals and significance level of 5% (P < 0.05) were calculated. Allele frequencies in the SNP rs9277535 were 72.6% for A and 27.4% for G nucleotides in cases and 75.0% for A and 25.0% for G in controls. Allele frequencies in the SNP rs7453920 were of 25.7% for A and 74.3% for G in cases and 28.8% for A and 71.2% for G in controls. No statistically significant association was found between both SNPs and chronic hepatitis B (P > 0.05).

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A global perspective on hepatitis B‐related single nucleotide polymorphisms and evolution during human migration

Tai

Jeng

Lin

2017

Hepatology Communications

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Genome‐wide association studies have indicated that human leukocyte antigen (HLA)‐DP and HLA‐DQ play roles in persistent hepatitis B virus (HBV) infection in Asia. To understand the evolution of HBV‐related single nucleotide polymorphisms (SNPs) and to correlate these SNPs with chronic HBV infection among different populations, we conducted a global perspective study on hepatitis‐related SNPs. We selected 12 HBV‐related SNPs on the HLA locus and two HBV and three hepatitis C virus immune‐related SNPs for analysis. Five nasopharyngeal carcinoma‐related SNPs served as controls. All SNP data worldwide from 26 populations were downloaded from 1,000 genomes. We found a dramatic difference in the allele frequency in most of the HBV‐ and HLA‐related SNPs in East Asia compared to the other continents. A sharp change in allele frequency in 8 of 12 SNPs was found between Bengali populations in Bangladesh and Chinese Dai populations in Xishuangbanna, China (P < 0.001); these areas represent the junction of South and East Asia. For the immune‐related SNPs, significant changes were found after leaving Africa. Most of these genes shifted from higher expression genotypes in Africa to lower expression genotypes in either Europe or South Asia (P < 0.001). During this two‐stage adaptation, immunity adjusted toward a weak immune response, which could have been a survival strategy during human migration to East Asia. The prevalence of chronic HBV infection in Africa is as high as in Asia; however, the HBV‐related SNP genotypes are not present in Africa, and so the genetic mechanism of chronic HBV infection in Africa needs further exploration. Conclusion: Two stages of genetic changes toward a weak immune response occurred when humans migrated out of Africa. These changes could be a survival strategy for avoiding cytokine storms and surviving in new environments. (Hepatology Communications 2017;1:1005–1013)

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Association between HLA Variations and Chronic Hepatitis B Virus Infection in Saudi Arabian Patients

Cited by 50 publications

References 29 publications

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis

Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population

A global perspective on hepatitis B‐related single nucleotide polymorphisms and evolution during human migration

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