Association between HLA and Japanese patients with rheumatoid arthritis

Japanese patients with primary Sjögren's syndrome (SS), patients with SS and rheumatoid arthritis (SS‐RA), and patients with SS and connective tissue disease without RA (nonrheumatoid connective tissue disease [SS‐CTD]) were typed for HLA antigens. Patients with primary SS and those with SS‐RA had higher frequencies of DRw53 than did those who had SS‐CTD; however, the group with SS‐CTD showed a negative correlation with DRw52. These data indicate that Japanese and white patients with SS have different HLA specificities, and that genetic factors involved in the development of SS‐CTD might be different from those in primary SS and SS‐RA.

Section: Discussionsupporting

confidence: 91%

“…We also confirmed that the association between DR4 and DRw53 haplotype in male Japanese RA patients is greater than that in female Japanese RA patients (13). Although we cannot explain why, no significant deviation in the HLA-DR2 frequency was observed in male patients compared with controls.…”

Section: Discussionsupporting

confidence: 81%

Association between HLA and Sjögren's syndrome in Japanese patients

Moriuchi¹,

Ichikawa²,

Takaya³

et al. 1986

“…HLA-Dw4 and Dw14 are increased among Caucasian subjects with RA, and Dw15 is increased among Japanese subjects with RA, while DwlO is absent among RA patients in both groups (39)(40)(41). In contrast, in another HLA-DR4-associated autoimmune dermatologic disease, pemphigus vulgaris, only the HLADw 10 subtype has been found to be associated with disease susceptibility, among an Ashkenazi Jewish patient population (15,16).…”

Section: Discussionmentioning

confidence: 96%

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

Kaneoka

Hsu

Takeda

et al. 1992

Objective. We have recently found that the presence of autoantibodies against the 70-kd polypeptide of U1 RNP (Ul-70-kd) is associated with HLA-DR4 and DR2. To further characterize this association, we performed a molecular genetic analysis of HLA-DR and DQ genes among patients with autoantibodies against Methods. The polymerase chain reaction (PCR), sequence-specific oligonucleotide hybridization, and U1-70-kd.

“…With regard to the importance of HLA-DC in determining susceptibility to RA, studies by Ohta et a1 (25) report that the frequency of MT3 positivity in Japanese subjects with seropositive RA (98%) is greater than the frequency of HLA-DR4 (75%). However, since the frequency of MT3 in the Japanese controls (62%) is also greater than the frequency of HLA-DR in controls (41%), the relative risks associated with MT3 (3.81) and DR4 (2.56) positivity are similar (no difference at the 95% confidence limit).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that products of genes linked to, but distinct from, those in the HLA-D region may be seen with greater frequency in RA (4,24,25 …”

Section: Collier Et Almentioning

confidence: 99%

Anticollagen antibodies and immune response gene products in rheumatoid arthritis

Kerwar

Garovoy

Fye

et al. 1984

Circulating antibodies to native and denatured types I and I1 human and bovine collagens were assayed in patients with rheumatoid arthritis (RA), patients with other rheumatic diseases, and normal individuals. A subgroup of this population was also assayed for reactivity with typing reagents which detect determinants (MT and HLA-DR) present in human immune response gene products. The mean titers of antibodies to each collagen tested were not significantly higher in RA patients when compared with patients who had other rheumatic diseases. Although both MT3 and MT4 were significantly associated with RA, there was no significant association between the anticollagen antibodies and any MT type or HLA-DR4. These studies raise a question concerning