Association Between HLA-A, B, DRB1 Alleles and Susceptibility or Resistance to Chronic Hepatitis B

Abstract

e41813th International Congress on Infectious Diseases Abstracts, Poster Presentations examined the association between the immune status and the psychological (perceived) stress in patients with chronic hepatitis B, and the involvement of cortisol.Methods: Forty patients with chronic hepatitis B completed the Perceived Stress Scale-14 (PSS-14) and State-Trait Anxiety Inventory (STAI-Form). These two scales are selfreport questionnaires to measure psychological stress, state anxiety and trait anxiety. We measured two types of T cellderived cytokines level (IL-10 and IFN) and plasma cortisol. Correlation analysis was employed to explore the relationship among psychological scores, cortisol and cytokine level.Results: Our results show that the level of IL-10 was related to psychological stress (P = 0.03), state anxiety (P = 0.01) and trait anxiety (P = 0.03). No correlations were found between psychological stress and IFN-␥ levels. Also no correlations were developed between cortisol and psychological stress, anxiety, IL-10, and IFN-␥.Conclusion: From the results, it can be concluded that psychological stress depresses the immune reaction in patients with chronic hepatitis B, which is disadvantage of HBV r esolve. Those patients were in great need of psychological support. Cortisorl plays little role between psychological stress and immune state in patient with hepatitis B.