Association between hippocampal microglia, AD and LATE‐NC, and cognitive decline in older adults
Alifiya Kapasi,
Lei Yu,
Sue E Leurgans
et al.
Abstract:INTRODUCTIONThis study investigates the relationship between microglia inflammation in the hippocampus, brain pathologies, and cognitive decline.METHODSParticipants underwent annual clinical evaluations and agreed to brain donation. Neuropathologic evaluations quantified microglial burden in the hippocampus, amyloid beta (Aβ), tau tangles, and limbic age‐related transactive response DNA‐binding protein 43 (TDP‐43) encephalopathy neuropathologic changes (LATE‐NC), and other common brain pathologies. Mixed‐effec… Show more
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