Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors

Abstract

High-sensitivity C-reactive protein (hsCRP) has been demonstrated to play a causal role in atherosclerosis and to predict cardiovascular events in the general population. On the other hand, left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography can also predict cardiovascular events in patients with cardiovascular risk factors. However, there are few data regarding the relationships among hsCRP, LV hypertrophy, and diastolic function. We examined the relationships among hsCRP, LV hypertrophy, and diastolic function in 185 patients (65 ± 11 years), who had no overt heart disease, but had cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia. Echocardiography was performed to measure the left ventricular mass index (LVMI) as a parameter of LV hypertrophy. LV diastolic function was assessed by the ratio (E/A) of early (E) and late (A) diastolic transmitral flows, early diastolic mitral annular velocity (E´), and the ratio (E/E´) of E to E´using Doppler echocardiography. The hsCRP was correlated with LVMI (r = 0.228, p = 0.002), E´ (r = −0.276, p < 0.001), and E/E´ (r = 0.419, p < 0.001). The E/E´ as a parameter of LV diastolic function showed the closest correlation to hsCRP. These results indicate that elevated hsCRP reflects LV diastolic dysfunction rather than LV hypertrophy. We therefore suggest that hsCRP may be a marker of subclinical LV diastolic dysfunction in patients with cardiovascular risk factors.

C-reactive protein is associated with ventricular repolarization dispersion among patients with metabolic syndrome

“…In present study increased levels of CRP, was associated independently with Obesity, BMI, uncontrolled glicemia and uncontrolled BP. Results they are consistent with prior studies [27][28][29][30]. Another fact of great importance is the in luence of medication on several elektrocardiographic parameters, there are numerous drugs that cause prolongation and/or dispersion of repolarization.…”

“…Others have found similar results [25,26]. A number of previous studies have demonstrated that CRP levels correspond with individual components of MetS [27,28]. In present study increased levels of CRP, was associated independently with Obesity, BMI, uncontrolled glicemia and uncontrolled BP.…”

Association between circulating FGF23, α-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction

“…First, we did not take left atrial volume index [31] into account, for the assessment of diastolic dysfunction has been done in other studies [32][33][34]. Second, although atrial fibrillation may increase the risk of diastolic heart failure, we excluded such patients, as has been done in other studies [35], due to an inability to assess E/A.…”

Anthropometric and Biochemical Markers as Possible Indicators of Left Ventricular Abnormal Geometric Pattern and Function Impairment in Obese Normotensive Children

“…Waist-to-height ratio has been tested as a surrogate for abdominal obesity in adults and children and seems to be a better predictor of cardiometabolic risk than BMI [56,57]. High sensitivity CRP is a biomarker that quantifies low grade systemic inflammation, in the absence of overt systemic inflammatory or immunologic disorders and has been used as a predictor of cardiovascular events [58], but has been also associated with diastolic dysfunction and heart failure in adults [59][60][61]. In the study of Dahiya et al in obese adolescents, CRP was an independent determinant of LV diastolic function [21].…”