Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

Olson, Fredrik J.; Engborg, J.; Grønhøj, Mette Hjortdal; Sand, Niels Peter; Lambrechtsen, Jess; Steffensen, Flemming Hald; Nybo, Mads; Gerke, Oke; Mickley, Hans; Diederichsen, Axel Cosmus Pyndt

doi:10.1016/j.atherosclerosis.2015.12.017

Cited by 16 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential ability of hs-cTnI to discriminate between the different CAC values, might allow to differentiate between patients at high risk and patients with no need for further diagnostic assessment [ 29 ]. These present findings are in accordance with a study by Olson et al showing an association between hs-cTnI and coronary calcium score in a Danish study cohort of 1173 clinically healthy subjects [ 24 ]. It was demonstrated that hs-cTnI was able to predict Agatston values greater than 100 and showed that adding hs-cTnI to the Heart-Score led to a significant increase in C-statistics for predicting coronary artery calcification.…”

Section: Discussionsupporting

confidence: 94%

“…Only few studies evaluated associations of hs-cTn and CAC screening. In a large Danish study cohort of clinical healthy subjects, an association of hs-cTnI and coronary calcium score was demonstrated [ 24 ]. Adding hs-cTnI to the Heart-Score led to a significant increase in discriminative C-statistics for predicting coronary artery calcification [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…In a large Danish study cohort of clinical healthy subjects, an association of hs-cTnI and coronary calcium score was demonstrated [ 24 ]. Adding hs-cTnI to the Heart-Score led to a significant increase in discriminative C-statistics for predicting coronary artery calcification [ 24 ]. Regarding hs-cTnT, a close correlation of hs-cTnT and the Agatston score in patients without known CAD presenting with chest pain was demonstrated [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score

et al. 2017

View full text Add to dashboard Cite

BackgroundThis study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD).MethodsPatients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD. Within 24 h of CCT examination, peripheral blood samples were taken to measure cardiac biomarkers hs-cTnI and hs-cTnT.ResultsA total of 76 patients were enrolled including 38% without detectable CAC, 36% with an Agatston score from 1 to 100, 17% from 101 to 400, and 9% with values ≥ 400. hs-cTnI was increasing alongside Agatston score and was able to differentiate between different groups of Agatston scores. Both hs-cTn discriminated values greater than 100 (hs-cTnI, AUC = 0.663; p = 0.032; hs-cTnT, AUC = 0.650; p = 0.048). In univariate and multivariate logistic regression models, hs-cTnT and hs-cTnI were significantly associated with increased Agatston scores. Patients with hs-cTnT ≥ 0.02 µg/l and hs-cTnI ≥ 5.5 ng/l were more likely to reveal values ≥ 400 (hs-cTnT; OR = 13.4; 95% CI 1.545–116.233; p = 0.019; hs-cTnI; OR = 8.8; 95% CI 1.183–65.475; p = 0.034).ConclusionThe present study shows that the Agatston score was significantly correlated with hs cardiac troponins, both in univariable and multivariable linear regression models. Hs-cTnI is able to discriminate between different Agatston values. The present results might reveal potential cut-off values for hs cardiac troponins regarding different Agatston values. Trial registration Cardiovascular Imaging and Biomarker Analyses (CIBER), NCT03074253 https://clinicaltrials.gov/ct2/show/record/NCT03074253

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Serum magnesium has been shown to be inversely related to CAC in the general population [ 34 , 35 ]. We have shown a significant association between magnesium and cTnT which has shown to be strongly associated with the presence of CAC [ 36 ] and adjustment for cTnT attenuated the magnesium-HF association further suggesting that CAC may be another mechanism by which magnesium may protect against HF. Moreover, age has shown to be the predominant risk factor for CAC [ 37 ] and asymptomatic CHD is known to be associated with increased risk of CAC [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

et al. 2018

View full text Add to dashboard Cite

To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60–79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained. Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]. Serum magnesium was inversely related to risk of incident HF after adjustment for conventional CVD risk factors and incident MI. The adjusted hazard ratios (HRs) for HF in the 5 quintiles of magnesium groups were 1.00, 0.72 (0.50, 1.05), 0.85 (0.59, 1.26), 0.76 (0.52, 1.11) and 0.56 (0.36, 0.86) respectively [p (trend) = 0.04]. Further adjustment for atrial fibrillation, IL-6, vWF and FEV1 attenuated the association but risk remained significantly reduced in the top quintile (≥ 0.87 mmol/l) compared with the lowest quintile [HR 0.62 (0.40, 0.97)]. Adjustment for NT-proBNP and cTnT attenuated the association further [HR 0.70 (0.44, 1.10)]. The benefit of high serum magnesium on HF risk was most evident in men with ECG evidence of ischaemia [HR 0.29 (0.13, 0.68)]. The potential beneficial effect of high serum magnesium was partially explained by its favourable association with CVD risk factors. Further studies are needed to investigate whether serum magnesium supplementation in older adults may protect from the development of HF.

show abstract

“…Although not specific to myocardial infarction, detectable troponin is extremely sensitive in the diagnosis of AMI. High-sensitive troponin assays have demonstrated the ability to improve time to diagnosis of AMI as well as predict CVD in those without symptoms or known CVD [11,12]. Measureable levels using contemporary or high-sensitive troponin assays are indicative of underlying cardiac damage in ACS and other pathologic conditions including HF, pulmonary embolism, and arrhythmias.…”

Section: Troponinmentioning

confidence: 99%

The Role of Biomarkers in Detection of Cardio-toxicity

et al. 2017

View full text Add to dashboard Cite

The goal of this paper is to review the current literature on the role of biomarkers in the detection and management of patients with cardio-oncologic disease. The role of biomarker surveillance in patients with known cardiac disease, as a result of chemotherapy or with the potential to develop cardio-toxicity, will be discussed. In addition, the studies surrounding sub-clinical cardiac toxicity monitoring during therapy, identification of high-risk patients prior to therapy, and tailoring oncologic therapies to potential biomarker risk profiles are reviewed. Based on evidence, to date, troponin and natriuretic peptides have the greatest potential to detect sub-clinical cardiac dysfunction and even tailor therapy to prevent progression based on biomarker profiles. Finally, future directions for potential utilization of novel biomarkers for the improvement of care of patients in the field of cardio-oncology are discussed.

show abstract

Association between high-sensitive troponin I and coronary artery calcification in a Danish general population

Cited by 16 publications

References 21 publications

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score

Comparative analysis of high-sensitivity cardiac troponin I and T for their association with coronary computed tomography-assessed calcium scoring represented by the Agatston score

Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

The Role of Biomarkers in Detection of Cardio-toxicity

Contact Info

Product

Resources

About