Association between high normal-range thyrotropin concentration and carotid intima-media thickness in euthyroid premenopausal, perimenopausal and postmenopausal women

Sakamaki, Koji; Tsunekawa, Katsuhiko; Ishiyama, Nobuyoshi; Kudo, Mizuho; Ando, Kimiko; Akuzawa, Masako; Nakajima, Katsuyuki; Shimomura, Yoshiharu; Araki, Osamu; Kimura, Takao; Murakami, Masami

doi:10.1016/j.maturitas.2020.10.022

Cited by 10 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the various changes of thyroid hormones in patients with CHD (32), the various effects of thyroid hormones in patients with CHD (33) and carotid plaque deserve attention (34). However, previous studies showed that higher TSH (11), lower TSH (35), lower FT3 (34), higher FT3, and higher FT4 (10) levels were all associated with the risk of carotid plaque. Inconsistent findings from previous studies have highlighted that TSH or thyroid hormone levels alone may not be sufficient with the same range and interpretation as an approximation.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported an association between thyroid hormone levels and carotid plaque formation ( 36 , 37 ). A cross-sectional study found that TSH was independently associated with carotid plaque, especially in participants with elevated TSH levels ( 11 ). A prospective cohort study in a Chinese population reported that higher mean levels and higher values of changes in FT3 and FT4 were associated with a higher risk of carotid atherosclerosis in euthyroid middle-aged and older participants ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…A prospective cohort study reported that the greater the changes in thyroid hormone levels in euthyroid, middle-aged, or older participants, the higher the risk of carotid atherosclerosis (10). Sakamaki et al (11) believed that thyroid stimulating hormone (TSH) was independently associated with carotid plaque, especially when the TSH level was ≥2.5 mIU/mL. However, another cross-sectional study (12) found that TSH and free thyroxine (FT4) were not significantly associated with carotid plaque.…”

Section: Introductionmentioning

confidence: 99%

“…Sakamaki et al. ( 11 ) believed that thyroid stimulating hormone (TSH) was independently associated with carotid plaque, especially when the TSH level was ≥2.5 μIU/mL. However, another cross-sectional study ( 12 ) found that TSH and free thyroxine (FT4) were not significantly associated with carotid plaque.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

Liu

Yang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

ContextPrevious studies on the association between thyroid function and carotid plaque have shown contradictory results, which may be attributable to the sensitivity to thyroid hormone indices. This study aimed to analyze the association between thyroid hormone sensitivity and risk of carotid plaque in patients with coronary heart disease (CHD) and further explore this association according to sex, age, smoking, and drinking status.MethodsThis large-scale, multi-center, retrospective, cross-sectional study included 6679 patients with CHD (age 35–75). Central sensitivity to thyroid hormone was evaluated by the thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyroid-stimulating hormone index (TSHI), and thyrotroph thyroxine resistance index (TT4RI). Peripheral sensitivity to thyroid hormone was assessed by free triiodothyronine/free thyroxine (FT3/FT4) ratio. Taking no carotid plaque as a reference, this study used logistic regression to analyze the association between central and peripheral thyroid hormone sensitivity and carotid plaque in patients with CHD.ResultsOf the 6679 patients with CHD, 4843 (72.50%) had carotid plaque. In the multi-adjusted models, the TFQI (odds ratio [OR]: 1.50; 95% confidence interval [CI]: 1.26–1.78; P < 0.001), PTFQI (OR: 1.76; 95% CI: 1.46–2.12; P < 0.001), TSHI (OR: 1.21; 95% CI: 1.10–1.33; P < 0.001), and TT4RI (OR: 1.00; 95% CI: 1.00–1.01; P = 0.003) were positively associated with the risk of carotid plaque. Compared with that in females and people > 60 years, the OR value for carotid plaque was higher in males and people ≤ 60 years. Similarly, smokers and drinkers had higher OR values for carotid plaque than non-smokers and non-drinkers. Conversely, FT3/FT4 ratio (OR: 0.75; 95% CI: 0.70–0.81; P < 0.001) was negatively associated with carotid plaque, and the OR value for carotid plaque was lower in males, patients ≤ 60 years, smokers, and drinkers.ConclusionThis study showed that thyroid hormone sensitivity is significantly associated with carotid plaque in patients with CHD. This association is more significant in males, patients ≤ 60 years, smokers, and drinkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

Liu

Yang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The mechanism of association between TSH in the upper part of the reference range and increased risk of STEMI follow-up mortality is not clear. Some researchers reported that TSH levels in the upper part of the reference range are associated with endothelial dysfunction ( 16 ), unsteady systolic and diastolic blood pressure ( 17 , 18 ), arterial stiffness ( 19 ), metabolic syndrome ( 20 ), and less favorable lipid levels ( 21 ). Meanwhile, studies have found that TSH can promote inflammation by stimulating adipose tissue pro-inflammatory cytokines ( 22 ), increase cardiometabolic disorders ( 23 ), affect heart remodeling after myocardial infarction ( 24 ), and increase higher thrombus burden ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Normal Thyroid Stimulating Hormone in Long-Term Mortality in Patients With STEMI

et al. 2022

View full text Add to dashboard Cite

BackgroundAlthough within the normal range, thyroid stimulating hormone (TSH) levels are associated with cardio-metabolic disorders and have an effect on the cardiovascular system. The aim of our study was to assess the prognostic value of normal TSH on long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI).MethodsConsecutive STEMI patients who had a TSH level within the normal range (0.55–4.78 μIU/ml) were enrolled from November 2013 to December 2018. Patients were stratified into three groups depending on the tertile of TSH level, and all-cause mortality and cardiac death were compared. TSH concentrations associated with risk of all-cause mortality were evaluated in a continuous scale (restricted cubic splines) and the Cox proportional hazards regression model.ResultsA total of 1,203 patients with STEMI were eligible for analysis. During a median follow-up of 39 months, patients in the 3rd tertile group had higher all-cause mortality (20.1% vs. 12.2% and 14.3%, p = 0.006) and cardiac death (15.4% vs. 7.7% and 12.3%, p = 0.001) as compared to the 1st and 2nd tertile groups. The Cox proportional hazards model showed that TSH was an independent predictor on long-term all-cause mortality (HR: 1.248, 95% CI: 1.046–1.490, p = 0.014). However, subgroup analysis indicated that TSH (HR: 1.313, 95% CI: 1.063–1.623, p = 0.012) was only significantly associated with long-term all-cause mortality in the patients without emergency reperfusion therapy. Restricted cubic spline analyses showed a linear relationship between TSH concentrations and all-cause mortality (P for non-linearity = 0.659).ConclusionsA Higher TSH level - even in a normal range is associated with long-term mortality in patients with STEMI, proposing an additional indication to identify STEMI patients with poor prognosis.

show abstract

Thyroid disorders in elderly: A comprehensive review

Thiruvengadam

Luthra

2021

Disease-a-Month

View full text Add to dashboard Cite

Association between high normal-range thyrotropin concentration and carotid intima-media thickness in euthyroid premenopausal, perimenopausal and postmenopausal women

Cited by 10 publications

References 29 publications

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

Prognostic Value of Normal Thyroid Stimulating Hormone in Long-Term Mortality in Patients With STEMI

Thyroid disorders in elderly: A comprehensive review

Contact Info

Product

Resources

About