Association Between High Initial Tissue Levels of Cyclin D1 and Recurrence of Nasopharyngeal Carcinoma

Lai, Jinping; Tong, Caili; Cheng, Hong; Jian-yun, Xiao; Tao, Zhengde; Zhang, Zheng; Tong, Wei‐Min; Betz, Christian

doi:10.1097/00005537-200202000-00036

Cited by 28 publications

(19 citation statements)

References 30 publications

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“…recurrent NPC specimens found in this study (26%) was not higher, but slightly lower than those reported for previously untreated NPC (30% to 66%) [7,9,18].…”

Section: Kaplan-meier Survival Curvecontrasting

confidence: 83%

Cyclin D1 and P16 expression in recurrent nasopharyngeal carcinoma

Lin

Berry²,

Sun³

et al. 2003

Otolaryngology - Head and Neck Surgery

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Background: Cyclin D1 and p16 are involved in the regulation of G1 checkpoint and may play an important role in the tumorigenesis of nasopharyngeal carcinoma (NPC). Previous studies have examined the level of expression of cyclin D1 and p16 in primary untreated NPC but no such information is available for recurrent NPC. We set out in this study to examine the expression level of cyclin D1 and p16 in recurrent NPC that have failed previous treatment with radiation +/-chemotherapy.

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“…recurrent NPC specimens found in this study (26%) was not higher, but slightly lower than those reported for previously untreated NPC (30% to 66%) [7,9,18].…”

Section: Kaplan-meier Survival Curvecontrasting

confidence: 83%

Cyclin D1 and P16 expression in recurrent nasopharyngeal carcinoma

Lin

Berry²,

Sun³

et al. 2003

Otolaryngology - Head and Neck Surgery

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“…Moreover, particular attention should be paid to the differences in histological types, ethnic composition and stage distribution, since treatment results may differ in function of these characteristics [10,61]. Optimal choice of treatment might be further facilitated by a better understanding of the biology of nasopharyngeal cancers [19,32].…”

Section: Discussionmentioning

confidence: 99%

Hyperfractionated Radiotherapy in Locally Advanced Nasopharyngeal Cancer

et al. 2004

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Hyperfractionated radiotherapy seems a feasible and active regimen in locally advanced nasopharyngeal carcinoma. Accompanying acute and late toxicity is acceptable and does not compromise delivery of the planned irradiation dose. This regimen is associated with a high local control rate; relatively high nodal and distant failure, however, call for further treatment modifications, e. g., optimization of irradiation technique and/or dose escalation as well as improved systemic therapies.

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“…Previous studies revealed that elevated levels of cyclin D1 confer radiation resistance of cancer cells (29,30) and high levels of cyclin D1 correlate with unfavorable response to radiotherapy (31,32). Conversely, suppression of cyclin D1 sensitizes cancer cells to DNA damage (29,33).…”

Section: P16ink4a Inhibits Recruitment Of Rad51 To the Sites Of Dna Dmentioning

confidence: 99%

p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors

et al. 2014

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The p16INK4a protein is a principal cyclin-dependent kinase inhibitor that decelerates the cell cycle. Abnormally high levels of p16INK4a are commonly observed in human papillomavirus (HPV)-positive head and neck squamous cell carcinomas (HNSCC). We and others found that p16INK4a overexpression is associated with improved therapy response and survival of patients with HNSCC treated with radiotherapy. However, the functional role of p16INK4a in HNSCC remains unexplored. Our results implicate p16INK4a in regulation of homologous recombination-mediated DNA damage response independently from its role in control of the cell cycle. We found that expression of p16INK4a dramatically affects radiation sensitivity of HNSCC cells. p16INK4a overexpression impairs the recruitment of RAD51 to the site of DNA damage in HPV-positive cells by downregulating of cyclin D1 protein expression. Consistent with the in vitro findings, immunostaining of HNSCC patient samples revealed that high levels p16INK4a expression significantly correlated with decreased cyclin D1 expression. In summary, these findings reveal an unexpected function of p16INK4a in homologous recombination-mediated DNA repair response and imply p16INK4a status as an independent marker to predict response of patients with HNSCC to radiotherapy. Cancer Res; 74(6);

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Association Between High Initial Tissue Levels of Cyclin D1 and Recurrence of Nasopharyngeal Carcinoma

Cited by 28 publications

References 30 publications

Cyclin D1 and P16 expression in recurrent nasopharyngeal carcinoma

Cyclin D1 and P16 expression in recurrent nasopharyngeal carcinoma

Hyperfractionated Radiotherapy in Locally Advanced Nasopharyngeal Cancer

p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors

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