Association between high galectin expression and poor prognosis in hematologic cancers: a systematic review and meta-analysis

Liu, H. J.; Dai, Qiuying; Li, Yixian; Tang, Zhipeng; She, Tiantian

doi:10.1080/16078454.2023.2227494

Cited by 2 publications

(3 citation statements)

References 59 publications

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“…However, one has to remember that Gal-9 is known to be produced and secreted by various cell types including cancer cells and neighboring non-neoplastic cells (T-and B-lymphocytes, monocytes, dendritic cells, macrophages, etc.) [1]. Additionally, Gal-9 can be found both extra-and intracellulary.…”

Section: Discussionmentioning

confidence: 99%

“…Galectins are a family of β-galactoside-binding lectins with a conserved carbohydrate recognition domain (CRD) [1,2]. Since their identification in 1976, 16 galectins have been described [3].…”

Section: Introductionmentioning

confidence: 99%

“…For example, in patients with renal cell carcinoma, high Gal-9 expression was linked to poor survival [18]. In patients with acute myeloid leukemia (AML) who failed treatment, Gal-9 expression was also significantly elevated [1,19]. The prognostic role of Gal-9 was also studied in chronic lymphocytic leukemia (CLL).…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Potential of Galectin-9 mRNA Expression in Chronic Lymphocytic Leukemia

Bojarska-Junak,

Kowalska,

Chocholska

et al. 2023

Cancers

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Galectin-9 (Gal-9), very poorly characterized in chronic lymphocytic leukemia (CLL), was chosen in our study to examine its potential role as a CLL biomarker. The relation of Gal-9 expression in malignant B-cells and other routinely measured CLL markers, as well as its clinical relevance are poorly understood. Gal-9 mRNA expression was quantified with RT-qPCR in purified CD19+ B-cells of 100 CLL patients and analyzed in the context of existing clinical data. Our results revealed the upregulation of Gal-9 mRNA in CLL cells. High Gal-9 mRNA expression was closely associated with unfavorable prognostic markers. In addition, Gal-9 expression in leukemic cells was significantly elevated in CLL patients who did not respond to the first-line therapy compared to those who did respond. This suggests its potential predictive value. Importantly, Gal-9 was an independent predictor for the time to treatment parameters. Thus, we can suggest an adverse role of Gal-9 expression in CLL. Interestingly, it is possible that Gal-9 expression is induced in B-cells by EBV infection, so we determined the patients’ EBV status. Our suggestion is that EBV coinfection could worsen prognosis in CLL, partly due to Gal-9 expression upregulation caused by EBV.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic Potential of Galectin-9 mRNA Expression in Chronic Lymphocytic Leukemia

Bojarska-Junak,

Kowalska,

Chocholska

et al. 2023

Cancers

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The expression of Galectin‐9 correlates with mTOR and AMPK in murine colony‐forming erythroid progenitors

Tsukamoto

2024

European J of Haematology

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ObjectivesGalectin‐9 (Gal‐9) is an immune checkpoint ligand for T‐cell immunoglobulin and mucin domain 3. Although the roles of Gal‐9 in regulating immune responses have been well investigated, their biological roles have yet to be fully documented. This study aimed to analyse the expression of Gal‐9 bone marrow (BM) cells in C57BL/6J (B6) mice. Furthermore, the co‐expression of Gal‐9 with the mammalian target of rapamycin (mTOR) and AMP‐activated protein kinase (AMPK) was investigated.MethodsThe BM cells in adult C57BL/6J (B6) mice were collected and analysed in vitro.ResultsIn a flow cytometric analysis of BM cells, Gal‐9 was highly expressed in c‐KithiSca‐1−CD34−CD71+ erythroid progenitors (EPs), whereas it was downregulated in more differentiated c‐KitloCD71+TER119+ cells. Subsequently, a negative selection of CD3−B220−Sca‐1−CD34−CD41−CD16/32− EPs was performed. This resulted in substantial enrichment of KithiCD71+Gal‐9+ cells and erythroid colony‐forming units (CFU‐Es), suggesting that the colony‐forming subset of EPs are included in the KithiCD71+Gal‐9+ population. Furthermore, we found that EPs had lower mTOR and AMPK expression levels in Gal‐9 knockout B6 mice than in wild‐type B6 mice.ConclusionsThese results may stimulate further investigation of the role of Gal‐9 in haematopoiesis.

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Association between high galectin expression and poor prognosis in hematologic cancers: a systematic review and meta-analysis

Cited by 2 publications

References 59 publications

Prognostic Potential of Galectin-9 mRNA Expression in Chronic Lymphocytic Leukemia

Prognostic Potential of Galectin-9 mRNA Expression in Chronic Lymphocytic Leukemia

The expression of Galectin‐9 correlates with mTOR and AMPK in murine colony‐forming erythroid progenitors

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