Association between hidradenitis suppurativa and atopic diseases: a multi-center, propensity-score-matched cohort study

Abstract

Background: Cross-sectional evidence has suggested a high prevalence of atopic diseases in patients with hidradenitis suppurativa (HS). However, there is a lack of evidence based on longitudinal studies. This study aimed to assess the risk of different atopic diseases, including asthma, atopic dermatitis, and allergic rhinitis, in patients with HS. Methods: In this retrospective cohort study, data from the TriNetX research network were obtained. Patients with HS were enrolled, and a 1:1 propensity score matching was performed to select a non-HS control group. Matching covariates included age, sex, race, comorbidities, comedications, socioeconomic status, lab data, and medical utilization status. Hazard ratios (HR) for atopic diseases were assessed. Results: Over a 15-year follow-up period, patients with HS were found to be at a higher risk for atopic dermatitis (HR = 1.65; 95% CI, 1.44-1.90), asthma (HR = 1.41; 95% CI, 1.33-1.49), and allergic rhinitis (HR = 1.08; 95% CI, 1.03-1.13). A similar trend was observed in shorter follow-up periods. The association between HS, atopic dermatitis, and asthma was consistent across different age and sex subgroups. Conclusion: Atopic diseases including atopic dermatitis, asthma and allergic rhinitis are associated with HS. Further investigation is needed to assess the necessity of early screening for atopic diseases in patients with HS.

Risk of Keratitis and Keratopathy in Hidradenitis Suppurativa Patients: A Global Federated Health Network Analysis

“…Moreover, the risk of keratopathy was especially observed in the female HS population, with the risk of greater than 1.6fold compared with non-HS female controls (HR=1.61; 95%CI=1. 24 Previous studies have reported different inflammatory eye diseases (IED) in the context of HS, among which uveitis was the most common manifestation of IED (14,15). Keratitis only accounted for 23.5% (15) and 5% ( 14) of cases in these reports.…”

“…We utilized data from the TriNetX research network, a global federated health network that aggregates electronic health records from over 100 collaborative healthcare organizations (HCOs) worldwide. TriNetX is a widely utilized platform in epidemiological and clinical dermatology research (24,25). The records within the TriNetX database undergo a comprehensive de-identification process, negating the requirement for informed consent in studies utilizing this database.…”

Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

“…This subset retrieved the health data from 60 HCOs in the United States, and contained greater than 80 million patients' data. This subset of TriNetX was widely applied in epidemiological studies in various fields of clinical investigation [33][34][35] .…”