Association Between Hemoglobin and Major Adverse Cardiac Events: A Secondary Analysis from A Retrospective Cohort Study

Feng, Caiyun; Ye, Yongxiu; Wang, Ting; Xiong, Hongkai

doi:10.1016/j.amjms.2021.07.003

Cited by 1 publication

(2 citation statements)

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“…All data used in this study was downloaded from the Dryad Digital Repository ( https://datadryad.org/ ). The Dryad Digital Repository is a non-profit website, supported by the National Science Foundation of the United States 19 . It is a data platform that stores the raw data behind scientific publications, for reuse and reference.…”

Section: Methodsmentioning

confidence: 99%

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Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

Liu

2022

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The aim of this study is to explore the association between the aspartate amino transferase (AST)/alanine aminotransferase (ALT) ratio and all-cause mortality (ACM) in stable coronary artery disease (CAD) patients treated by percutaneous coronary intervention (PCI). The study is a secondary analysis of a retrospective cohort study involving 203 stable CAD patients. Patients were divided into two groups, based on the optimal AST/ALT ratio threshold calculated by the ROC curve (low group: AST/ALT ratio < 1.40; high group: AST/ALT ratio ≥ 1.40). Results were compared using hazard ratio (HR) and a 95% confidence interval (CI). ACM occurred in 18 patients after an average follow-up time of 749 (435–1122) days. Among them, ACM occurred in 6 patients in the low group and 12 patients in the high group, with significant differences between the groups (4.65% versus 16.22%, P value = 0.005). In the Kaplan–Meier analysis, an elevated AST/ALT ratio was associated with increased ACM in stable ACD patients (HR 3.78, 95% CI 1.44–9.93, P value < 0.001). An elevated AST/ALT ratio was still found to be an independent prognostic factor for ACM (HR 2.93, 95% CI 1.08–7.91, P value = 0.034) after adjusting for potential confounders. Therefore, an elevated AST/ALT ratio is an independent prognostic factor for ACM in stable ACD patients.

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Section: Methodsmentioning

confidence: 99%

“…Furthermore, considering the possibility of multicollinearity among variables 24 , Pearson correlation analysis was performed to identify the correlation between variables. If a variable is highly correlated with the AST/ALT ratio, those covariates are excluded from the Cox proportional hazard regression analysis 25 .…”

Section: Methodsmentioning

confidence: 99%

Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

Liu

2022

Sci Rep

View full text Add to dashboard Cite

show abstract

Association Between Hemoglobin and Major Adverse Cardiac Events: A Secondary Analysis from A Retrospective Cohort Study

Cited by 1 publication

References 41 publications

Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

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