Association between Helicobacter pylori infection and carotid atherosclerosis in patients with vascular dementia

Xu, Yuzhen; Wang, Qian; Liu, Yunling; Cui, Ruiting; Lu, Kaili; Zhao, Yuwu

doi:10.1016/j.jns.2016.01.025

Cited by 49 publications

(48 citation statements)

References 40 publications

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“…The results of the present study are in agreement with previous research indicating the association between H. pylori and dementia or neurodegenerative disorders [3-5, 7, 15, 35]. H. pylori infection is associated with higher risk of Alzheimer's disease, vascular dementia, Parkinson's disease, and neuromyelitis optica [14,[36][37][38][39][40][41][42]. However, the contribution of H. pylori to the development of neurodegeneration showing speci c topography of cortical thinning, was not previously reported.…”

Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

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Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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“…Specific pathogens, such as varicella zoster virus, influenza, Helicobacter pylori (Hp), Chlamydia pneumoniae, as well as periodontitis have been reported to be associated with stroke and potentially subsequent vascular dementia, a subtype of NAD [ 24 , 25 ]. A positive correlation between Hp infection and carotid atherosclerosis, for instance, has been demonstrated in patients with vascular dementia [ 26 ]. Moreover, the prospective Northern Manhattan Study suggests that atherosclerosis is associated with infectious burden index, serologically measured for five pathogens, including Hp, Chlamydia pneumonia, cytomegalovirus, and herpes simplex virus 1 and 2 [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Septicemia is associated with increased risk for dementia: a population-based longitudinal study

et al. 2017

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BackgroundSystemic infection has been linked to cognitive impairment. We hypothesized that patients with septicemia are predisposed to increased risks for developing dementia in a long-term setting.MethodsThis observational, retrospective, longitudinal, nation-wide population-based study was conducted using the data deduced from Longitudinal Health Insurance Database (LHID) in Taiwan. All patients with septicemia hospitalized for the first time from 2001 to 2011 without prior dementia were included. The development of Alzheimer's disease (AD) or non-Alzheimer dementias (NAD) in relation to the development of septicemia for each patient was recorded. An age- and sex-matched cohort without septicemia and without prior dementia served as the control. Septicemia, dementia, and other confounding factors were defined according to International Classification of Diseases Clinical Modification Codes. Cox proportional-hazards regressions were utilized to analyze adjusted hazard ratios.ResultsPatients with septicemia had a higher risk for developing dementia based on hazard ratios (HRs) (p<0.001). Patients with septicemia in the younger age groups had a greater dementia risk (p<0.01). Septicemia was associated with subsequent NAD (p<0.001), whereas the increased risk of AD was statistically insignificant (p>0.05). Furthermore, higher severity of septicemia was associated with increased risk of developing dementia.ConclusionsOur findings suggest that septicemia is associated with an increased risk in developing NAD but not AD. A likely causal role of septicemia in increasing the risk of NAD is suggested, according to the findings that patients with higher severity of septicemia carried greater risk of sustaining dementia.

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“…A recent paper by Xu et al., who studied 354 patients with vascular dementia (VD) for H. pylori infection, traditional cardiovascular (CV) risk factors, and the pro‐inflammatory peptide YKL‐40, reported significantly higher levels of this peptide in H. pylori ‐positive VD patients compared to noninfected patients ( P <.05). Moreover, H. pylori positivity correlated with YKL‐40 levels as well as with carotid intima‐media thickness (r=.412; P <.05) independently of traditional CV risk factors (r=.381; P <.001) . On the contrary, Jang et al., who studied H. pylori infection in 1117 patients undergoing brain magnetic resonance imaging (MRI), showed no association between this infection and the presence of small vessel disease [0.89 (95% CI, 0.48–1.62)] .…”

Section: Neurologic Diseasesmentioning

confidence: 99%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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Association between Helicobacter pylori infection and carotid atherosclerosis in patients with vascular dementia

Cited by 49 publications

References 40 publications

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Septicemia is associated with increased risk for dementia: a population-based longitudinal study

Helicobacter pylori and extragastric diseases

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