Association between Helicobacter pylori infection and cognitive impairment in the elderly

Han, Ming‐Lun; Chen, Jen‐Hau; Tsai, Min-Kuang; Liou, Jyh‐Ming; Chiou, Jeng‐Min; Chiu, Ming‐Jang; Chen, Yen‐Ching

doi:10.1016/j.jfma.2017.11.005

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…Previous researches have been performed to examine the association between H. pylori infection and various cognitive outcomes, including all-cause and AD dementia. However, the association is not fully understood [ 23 – 26 ]. Our results are limited to observational studies suggest that H. pylori infection may be an independent risk factor for all-cause dementia, but not for AD.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies

Liu

Sun

Jiang

et al. 2021

Aging

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Background: Infection with multiple pathogens may play a key role in the pathogenesis of dementia. Whether Helicobacter pylori ( H. pylori ) infection is associated causally with dementia is controversial. Objective: We conduct a meta-analysis of case-control and cohort studies on the association between H. pylori infection and the risk for all-cause and Alzheimer’s disease (AD) dementia. Methods: Two independent reviewers searched the PubMed, Cochrane Library, and Embase databases with English language restrictions from the date of conception to September 18, 2020. The primary analysis was as follows: the exposure variable was H. pylori infection, and the outcome was incident all-cause and AD dementia. Pooled odds ratios (OR), relative risk (RR), and corresponding 95% confidence intervals (CI) were obtained using the fixed-or random-effect model. Forest plots were generated to summarize the results. Results: Ten studies involving 96,561 participants were included in the meta-analysis: 5 case-control studies and 5 cohort studies. The overall pooled cohort studies showed a significant positive association between H. pylori infection and all-cause dementia with pooled RR of 1.36 (95% CI, 1.11-1.67). There was no association between H. pylori infection and risk for developing AD: RR of 1.33 (95% CI, 0.86-2.05) in cohort studies, and OR of 1.72 (95% CI, 0.97-3.04) in case-control studies. Significant heterogeneity was showed in each comparison group. Conclusion: This meta-analysis supports a positive association between H. pylori infection and the risk of all-cause dementia, but not AD dementia. Due to the interference of confounding factors, randomized controlled trials are needed to prove their causality.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies

Liu

Sun

Jiang

et al. 2021

Aging

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“…Several studies have established association between H. pylori infection and cardiovascular diseases [59, 60], yet a few other studies failed to find any association [61, 62]. Chronic inflammation secondary to ongoing H. pylori infection may play a role in developing or worsening Alzheimer dementia [63–65] and vascular dementia [66]. The association between compromised bone mineral density and H. pylori infection has been supported by recent investigations [52, 67].…”

Section: Stomachmentioning

confidence: 99%

Gastrointestinal Tract Disorders in Older Age

Dumić

Nordin

Jecmenica

et al. 2019

Canadian Journal of Gastroenterology and Hepatology

186

111

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Considering an increase in the life expectancy leading to a rise in the elderly population, it is important to recognize the changes that occur along the process of aging. Gastrointestinal (GI) changes in the elderly are common, and despite some GI disorders being more prevalent in the elderly, there is no GI disease that is limited to this age group. While some changes associated with aging GI system are physiologic, others are pathological and particularly more prevalent among those above age 65 years. This article reviews the most important GI disorders in the elderly that clinicians encounter on a daily basis. We highlight age-related changes of the oral cavity, esophagus, stomach, small and large bowels, and the clinical implications of these changes. We review epidemiology and pathophysiology of common diseases, especially as they relate to clinical manifestation in elderly. Details regarding management of specific disease are discussed in detail if they significantly differ from the management for younger groups or if they are associated with significant challenges due to side effects or polypharmacy. Cancers of GI tract are not included in the scope of this article.

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“…[ 1 ] HP seropositivity in patients has been found to be associated with the increased incidence of various of diseases, including cardiovascular, respiratory, extragastroduodenal, digestive, nervous, and other autoimmune diseases. For example, recent studies have shown that HP may be closely related to cognitive impairment, [ 10 ] neurodegenerative diseases, [ 11 ] including Parkinson disease, [ 12 , 13 ] Alzheimer disease, [ 14 ] depression, [ 15 ] the digestive system cancers such as CRC. [ 16 – 20 ] CRC or colorectal adenomas is closely correlated with higher incidence of HP infection in patients.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and the risk of colorectal cancer

et al. 2020

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Association between Helicobacter pylori infection and cognitive impairment in the elderly

Abstract: Our findings disclosed a positive association between serum H. pylori level and cognitive impairment, which provides important information for the primary prevention of cognitive impairment through the eradication of H. pylori.

Cited by 20 publications

References 34 publications

Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies

Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies

Gastrointestinal Tract Disorders in Older Age

Association between Helicobacter pylori infection and the risk of colorectal cancer

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