Association between Helicobacter pylori infection and the risk of gastric cancer in the Korean population: prospective case-controlled study

Chang, Woong Ki; Kim, Hak Yang; Kim, Dong Joon; Liu, Jin; Park, Choong Kee; Yoo, Jae Young; Kim, Hyun Ja; Kim, Mi Kyung; Choi, Bo Youl; Choi, Ho Soon; Park, Kyung Nam

doi:10.1007/s005350170003

Cited by 23 publications

(18 citation statements)

References 31 publications

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“…This PAF is very similar to that reported by Parkin [45]. For the sensitivity analysis, a meta-analysis was conducted for the summary risk measures from four case-control studies conducted in the Korean population with regard to the association between H. pylori and gastric cancer risk [17][18][19][20]. When the pooled RR of 1.69 from the Korean studies was applied, the PAFs due to H. pylori were 36.44% in men and 34.25% in women.…”

Section: Resultssupporting

confidence: 73%

“…We adopted the RR of 5.9 from the international metaanalysis of nested case-control studies for the current analysis [16] because four Korean studies had a case-control design [17][18][19][20] (supplemental Table 2 and Figure 1a and 1b, available at Annals of Oncology online). In addition, a matched OR of 6.3 from a nested case-control study of the association between H. pylori and gastric MALT lymphoma within an American cohort was adopted for the current analysis [21].…”

Section: Relative Risk Of Cancers and Infectious Agentsmentioning

confidence: 99%

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Population attributable fraction of infection-related cancers in Korea

Shin¹,

Park

Shin

et al. 2011

Annals of Oncology

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Background: A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population. Materials and methods:The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007.Results: The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV.Conclusion: Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.

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Section: Resultssupporting

confidence: 73%

Section: Relative Risk Of Cancers and Infectious Agentsmentioning

confidence: 99%

Population attributable fraction of infection-related cancers in Korea

Shin¹,

Park

Shin

et al. 2011

Annals of Oncology

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“…However, previous studies have shown the association between lower education and a high prevalence of H. pylori . [138] We recruited participants from the city of Pune but not from the nearby villages, and none of the participants in our study was uneducated. We came across a significant amount of missing data for the quantification of cigarettes and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Assessment of risk factors of helicobacter pylori infection and peptic ulcer disease

Mhaskar

Izurieta

Azizan

et al. 2013

J Global Infect Dis

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Background:Helicobacter pylori (H. pylori) infection is a risk factor for peptic ulcer. There have been no studies addressing environmental and dietary risk factors in western India. We conducted a case control study enrolling peptic ulcer patients in Pune, India.Materials and Methods:Risk factors for peptic ulcer and H. pylori infection were assessed in a participant interview. H. pylori status was assessed from stool by monoclonal antigen detection.Results:We enrolled 190 peptic ulcer, 35 stomach cancer patients, and 125 controls. Fifty-one percent (180/350) of the participants were infected with H. pylori. Lower socioeconomic status (SES) [odds ratio (OR): 1.10, 95% confidence interval (CI): 1.02–1.39], meat consumption (OR: 2.35, 95% CI: 1.30–4.23), smoking (OR: 2.23, 95% CI: 1.24–4.02), eating restaurant food (OR: 3.77, 95% CI: 1.39–10.23), and drinking nonfiltered or nonboiled water (OR: 1.05, 95% CI: 1.01–1.23) were risk factors for H. pylori infection. H. pylori infection (OR: 1.70, 95% CI: 1.03–2.89), meat (OR: 1.10, 95% CI: 1.02-1.75), fish (OR: 1.05, 95% CI: 1.02–1.89) consumption, and a family history of ulcer (OR: 1.20, 95% CI: 1.08–1.60) were risk factors for peptic ulcer. Consumption of chili peppers (OR: 0.20, 95% CI: 0.10–0.37) and parasite infestation (OR: 0.44, 95% CI: 0.24–0.80) were protective against H. pylori infection.Conclusion:H. pylori infection is associated with peptic ulcer. Lower SES, consumption of restaurant food, meat, nonfiltered water, and smoking are risk factors for H. pylori. Consumption of meat, fish, and a family history of peptic ulcer are risk factors for peptic ulcer. Consumption of chili peppers and concurrent parasite infestation appear to be protective against H. pylori.

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“…Since Virchow proposed that chronic inflammation promotes carcinogenesis, accumulating studies support the hypothesis that chronic inflammations increase the risk of cancer development (18)(19)(20)(21). Microbial infections, autoimmune disease, and inflammatory conditions of unknown origin are recognized as triggers of chronic inflammation related with cancer development, as well as the association of Helicobacter pylori (H. pylori) with gastric cancer and gastric mucosal lymphoma (18,19,22). Because a detailed histology of dissected regional LNs other than absence of tumor involvement is not obtained in this study, information as to the infection with H. pylori of the resected gastric specimens or regional LNs in gastric cancer patients is not available.…”

Section: Discussionmentioning

confidence: 99%