Association between helicobacter pylori infection and subclinical atherosclerosis

Wang, Xianghong; Jin, Donghua; Ma, Baohua; Yao, Kecheng; Zou, Xiulan

doi:10.1097/md.0000000000027840

Cited by 10 publications

(15 citation statements)

References 52 publications

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“…H. pylori -associated inflammation plays a major role in the development of atherosclerosis based on the wide spectrum of pro-inflammatory cytokines associated with this infection [ 213 ]. Several meta-analyses pointed out a significant positive association between H. pylori infection and the risk of atherosclerosis, proving that the infection has the ability to promote atherosclerosis development in people below the age of 60 years but also in those without cardiovascular risk factors [ 146 , 147 , 148 ] ( Table 2 ). In addition, this systemic inflammation induces the synthesis of acute phase coagulation proteins such as fibrinogen, which is particularly important in the development of coronary heart disease [ 214 ], thus also suggesting a possible link between H. pylori infection and other thrombotic events, including stroke.…”

Section: H Pylori and Cardiovascular Diseasesmentioning

confidence: 99%

Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Mărginean

Meliţ

2022

Children

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It is well documented that Helicobacter pylori (H. pylori) can cause both gastrointestinal and extraintestinal manifestations. The latter one represents a major burden in terms of diagnosis and treatment. H. pylori-associated systemic subclinical inflammation is mostly responsible for the development of extraintestinal manifestations, and its early eradication might result in preventing all adverse events related to their occurrence. Thus, it was suggested that H. pylori might be associated with iron deficiency anemia, thrombocytopenia (immune thrombocytopenic purpura), Schonlein Henoch purpura, failure to thrive, vitamin B12 deficiency, diabetes mellitus, body mass index, cardiovascular diseases, as well as certain neurological conditions. Nevertheless, studies showed both pros and cons in terms of the role of H. pylori in the development of previously mentioned clinical entity underlining the crucial need for further studies on these topics. Although most of these extraintestinal manifestations occur during adulthood, we must not forget that H. pylori infection is acquired mainly during childhood, and thus its early diagnosis and eradication might represent the cornerstone in the prevention of H. pylori-induced inflammatory status and consequently of all related extraintestinal conditions.

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Section: H Pylori and Cardiovascular Diseasesmentioning

confidence: 99%

Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Mărginean

Meliţ

2022

Children

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“…During the asymptomatic periods, there is a balance between damage and the host response, but in atherosclerosis it is possible to identify early signs or SCA [144,145]. SCA has been documented in H. pylori infected adults without a CVD diagnosis [146][147][148] and in H. pylori infected asymptomatic children [149]. In those children, alterations in the microbiota were documented with a strong association with Prevotella copri.…”

Section: H Pylori Might Predispose the Onset Of Atherosclerosismentioning

confidence: 99%

Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

Avilés-Jiménez

2022

BioMed Research International

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Cardiovascular diseases represent one of the first causes of death around the world, and atherosclerosis is one of the first steps in the development of them. Although these problems occur mainly in elderly, the incidence in younger people is being reported, and an undetermined portion of patients without the classic risk factors develop subclinical atherosclerosis at earlier stages of life. Recently, both the H. pylori infection and the intestinal microbiota have been linked to atherosclerosis. The mechanisms behind those associations are poorly understood, but some of the proposed explanations are (a) the effect of the chronic systemic inflammation induced by H. pylori, (b) a direct action over the endothelial cells by the cytotoxin associated gene A protein, and (c) alterations of the lipid metabolism and endothelial dysfunction induced by H. pylori infection. Regarding the microbiota, several studies show that induction of atherosclerosis is related to high levels of Trimethylamine N-oxide. In this review, we present the information published about the effects of H. pylori over the intestinal microbiota and their relationship with atherosclerosis and propose a hypothesis to explain the nature of these associations. If H. pylori contributes to atherosclerosis, then interventions for eradication and restoration of the gut microbiota at early stages could represent a way to prevent disease progression.

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“…Among other pathophysiological considerations, subclinical inflammation represents a possible link between infection with H. pylori and the development and progression of atherosclerosis. For example, an association between H. pylori positive and intima media thickness has been demonstrated 4,14 . In addition to studies on the association of H. pylori with intima media thickness, there are also studies suggesting a positive association of H. pylori positive with coronary calcification 15 …”

Section: Introductionmentioning

confidence: 99%

“…For example, an association between H. pylori positive and intima media thickness has been demonstrated. 4,14 In addition to studies on the association of H. pylori with intima media thickness, there are also studies suggesting a positive association of H. pylori positive with coronary calcification. 15 Nota bene, however, there are definitely signals for a sex-, age-, and especially ethnicity-specific relationship between H. pylori positive and cardiovascular risk or cardiovascular surrogate parameters in all studies.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and cardiovascular risk: Only a dead Helicobacter is a good Helicobacter?

et al. 2022

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Objectives Helicobacter pylori (H. pylori) and cardiovascular (CV) disease share common symptoms and underlie many general medical complaints. Preliminary studies suggest an association between H. pylori positivity and CV risk, and gastroenterological guidelines recommend eradication of H. pylori in patients with manifest atherosclerosis. Therefore, the aim of this study was to examine the reciprocal association of H. pylori positivity and CV risk for their independence of shared risk factors. Methods We included 3284 asymptomatic participants of a colorectal cancer screening cohort who were offered and underwent upper gastrointestinal endoscopy. We calculated the 10‐year risk for a CV event using the novel SCORE2 for each patient. We evaluated the association between H. pylori positivity and CV risk assessed by SCORE2 using both multilevel logistic and linear regression. We adjusted for age, sex and the concomitant diagnosis of metabolic syndrome. Lastly, we assessed the association between H. pylori status and mortality using proportional hazard Cox regression. Results In total, 2659 patients were H. pylori negative and 625 H. pylori positive. Helicobacter pylori positivity was associated with SCORE2 and remained so (r = .33; 95% CI 0.09–0.57; p = .006) after adjustment for age, sex, and the diagnosis of metabolic syndrome. Also, SCORE2 was associated with higher odds for H. pylori positivity (aOR 1.03 95% CI 1.01–1.05; p = .02) even after multivariable adjustment. Helicobacter pylori positivity was associated with neither CV (HR 0.60 95% CI 0.14–2.63; p = .50) nor all‐cause (HR 1.20 95% CI 0.77–1.87; p = .43) mortality during a median follow‐up of 9 years. Conclusions In our study, H. pylori positivity and CV risk were independently associated. This did not translate into a dissimilar CV mortality between H. pylori positive and H. pylori negative patients. However, the overwhelming majority of our patients underwent H. pylori eradication. We, therefore, think that H. pylori eradication is at least safe from a cardiovascular perspective and warranted from gastrointestinal standpoint.

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Association between helicobacter pylori infection and subclinical atherosclerosis

Cited by 10 publications

References 52 publications

Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Helicobacter pylori-Related Extraintestinal Manifestations—Myth or Reality

Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

Helicobacter pylori and cardiovascular risk: Only a dead Helicobacter is a good Helicobacter?

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