Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

Doheim, Mohamed Fahmy; Altaweel, Ahmad Amr; Elgendy, Mohamed Gamal; Elshanbary, Alaa Ahmed; Dibas, Mahmoud; Ali, Amira A. H.; Dahy, Toqa Mahmoud; Sharaf, Atef Khairy; Hassan, Ameer E.

doi:10.1007/s00415-020-09933-x

Cited by 18 publications

(16 citation statements)

References 56 publications

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“…Beyond H. pylori-related gastric pathologies [37], H. pylori infection is also associated with MetS-related systemic pathologies, especially cardio-cerebrovascular, and neurodegenerative diseases, the endpoints of MetS [38][39][40][41][42][43]. It is important to note that almost all the aforementioned potential causative agents involved in the pathogenesis of arterial hypertension are also involved in the pathophysiology of H. pylori-related pathologies [36,[38][39][40][42][43][44][45][46][47][48][49][50][51][52][53][54][55].…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

et al. 2021

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Arterial hypertension is a risk factor for several pathologies, mainly including cardio-cerebrovascular diseases, which rank as leading causes of morbidity and mortality worldwide. Arterial hypertension also constitutes a fundamental component of the metabolic syndrome. Helicobacter pylori infection is one of the most common types of chronic infection globally and displays a plethora of both gastric and extragastric effects. Among other entities, Helicobacter pylori has been implicated in the pathogenesis of the metabolic syndrome. Within this review, we illustrate the current state-of-the-art evidence, which may link several components of the Helicobacter pylori-related metabolic syndrome, including non-alcoholic fatty liver disease and arterial hypertension. In particular, current knowledge of how Helicobacter pylori exerts its virulence through dietary, inflammatory and metabolic pathways will be discussed. Although there is still no causative link between these entities, the emerging evidence from both basic and clinical research supports the proposal that several components of the Helicobacter pylori infection-related metabolic syndrome present an important risk factor in the development of arterial hypertension. The triad of Helicobacter pylori infection, the metabolic syndrome, and hypertension represents a crucial worldwide health problem on a pandemic scale with high morbidity and mortality, like COVID-19, thereby requiring awareness and appropriate management on a global scale.

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Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

et al. 2021

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“…7 Additionally, several infectious agents have been directly implicated in the development of stroke. [8][9][10] Some of these remain poorly investigated. This is particularly true for emerging infections, such as COVID-19, which pose a new opportunity to understand stroke pathophysiology.…”

Section: Authorsmentioning

confidence: 99%

The Correlation Between Stroke and Coronavirus Disease (COVID-19): Where is the Evidence?

Pittams

Axiaq

Qamar

et al. 2021

EMJ

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Stroke is the second leading cause of death globally. Despite the decreasing trend in stroke mortality, its incidence and prevalence follow an upwards trajectory that is envisaged to continue for years to come. Previous literature has suggested a role for infectious disease in stroke aetiology; however, the pathophysiological basis for this has never fully been understood. Emerging infections, such as coronavirus disease (COVID-19), present new challenges that must be addressed, to prevent them from contributing to the predicted rise in stroke incidence. Almost one in 20 patients diagnosed with COVID-19 experience a stroke thereafter, hence achieving better understanding of the interactions between these disease entities is of major clinical significance.

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“…In addition, because atherosclerosis is a chronic inflammatory disease, ongoing chronic infection may impact disease development (13). Several studies have shown an association between H. pylori infection and stroke (14)(15)(16)(17). A systematic review with the meta-analysis by Doheim et al associated the presence of anti-H. pylori IgG with an increased risk of stroke [odds ratio [OR] (95% CI) = 1.43 (1.25-1.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have shown an association between H. pylori infection and stroke ( 14 – 17 ). A systematic review with the meta-analysis by Doheim et al associated the presence of anti- H. pylori IgG with an increased risk of stroke [odds ratio [OR] (95% CI) = 1.43 (1.25–1.46)]( 15 ), and a retrospective study reported that patients with H. pylori infection had a higher incidence of ischemic stroke than uninfected patients ( 16 ). However, a few studies have found no association between H. pylori infection and stroke ( 18 – 20 ).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old

Guo

Zhang

et al. 2022

Front. Cardiovasc. Med.

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Background: Studies show inconsistent results regarding the relationship between Helicobacter pylori (H. pylori) infection and stroke. The present study assessed a potential association between H. pylori infection and an important risk factor for stroke, intracranial atherosclerosis.Methods: In total, 15,798 subjects with transcranial Doppler (TCD) and 13C-urea breath test (13C-UBT) were enrolled from March 2012 to March 2017. Intracranial atherosclerosis was further measured using intracranial carotid artery calcification (ICAC) on past or recent head CT, and 14,084 subjects were ultimately included in the study. Baseline demographics, atherosclerosis risk factors, and laboratory results were investigated. Since endothelial dysfunction is critical to the development of atherosclerosis, the role of H. pylori in migration, tube formation, and proliferation of human brain microvascular endothelial cells (HBMECs) was assessed in vitro.Results: The intracranial atherosclerosis group had a higher proportion of women and a greater rate of H. pylori infection than those without intracranial atherosclerosis. H. pylori infection was significantly more common in women with intracranial atherosclerosis than males. In addition, the incidence of intracranial atherosclerosis was significantly higher in women with H. pylori infection than uninfected women (53.8 vs. 46.4%, p < 0.001). In an adjusted model, H. pylori was shown to be an independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age [odds ratio (OR) = 2.261, 95% CI = 1.839–2.780, p < 0.001]. Serum exosomes from patients with H. pylori infection had significantly reduced brain endothelial cell migration, tube formation, and proliferation in vitro.Conclusion:Helicobacter pylori infection may be an important independent risk factor for intracranial atherosclerosis in women ≤ 60 years of age.

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Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients

Cited by 18 publications

References 56 publications

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

The Correlation Between Stroke and Coronavirus Disease (COVID-19): Where is the Evidence?

Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old

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