Association between Helicobacter pylori and liver-to-spleen ratio

Doğan, Zeynal; Filik, Levent; Ergül, Bilal; Sarıkaya, Murat; Akbal, Erdem

doi:10.1097/meg.0b013e3283590c10

Cited by 46 publications

(46 citation statements)

References 20 publications

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“…The effects of Ang II on splenic pathology are clearly apparent in our current investigation, with the assumption that this could lead to a number of immunological and haematological changes as suggested by a previous study . It is known that in the event of liver dysfunction, the spleen takes charge of certain functions especially involving the haematological system . Nevertheless, this can only be managed to a certain extent which otherwise could culminate in splenic pathology .…”

Section: Discussionsupporting

confidence: 65%

High‐fat diet‐ and angiotensin II‐induced aneurysm concurrently elicits splenic hypertrophy

Gopal

Nagarajan

Shankar

et al. 2014

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 65%

High‐fat diet‐ and angiotensin II‐induced aneurysm concurrently elicits splenic hypertrophy

Gopal

Nagarajan

Shankar

et al. 2014

Eur J Clin Investigation

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“…There is a large body of evidence showing the association of HP and CLD (22-26). The prevalence of HP like DNA in the liver tissue samples of patients with CLD was significantly higher than the patients with metastatic adenocarcinoma (2).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Helicobacter Pylori Eradication on Liver Fat Content in Subjects With Non-Alcoholic Fatty Liver Disease: A Randomized Open-Label Clinical Trial

et al. 2013

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BackgroundThe role of Helicobacter pylori (HP) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is unclear.ObjectivesThe aim of this study was to evaluate the effect of HP eradication on liver fat content (LFC), liver function tests (LFT), lipid profile, and homeostasis model assessment-IR (HOMA-IR) index in NAFLD.Patients and MethodsDyspeptic patients with increased serum aminotransferase levels were enrolled in the study. The exclusion criteria were factors affecting serum aminotransferase or HP treatment strategy. Participants with persistent elevated serum aminotransferase level and ultrasound criteria for identification of fatty liver were presumed to have NAFLD. “NAFLD liver fat score” was used to classify NAFLD. Those with “NAFLD liver fat score” greater than -0.64 and positive results for urea breath test (UBT), were included. Lifestyle modification was provided to all participants. HP eradication was performed in intervention arm. LFC, fasting serum glucose (FSG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), cholesterol (CHOL), high and low-density lipoprotein (HDL, LDL), and HOMA-IR were checked at baseline and after that, at intervals of eight weeks and twenty four weeks.ResultsOne hundred (49 males) patients with the mean age of 43.46 (± 11.52) were studied. Repeated measure ANOVA showed a significant reduction in LFC, anthropometric measurements, and laboratory parameters (except for HDL) in the both groups during the study; however, no significant difference was observed between the groups.ConclusionsIt seems that HP eradication per se might not affect LFC, LFT, lipid profile, and insulin resistance in dyspeptic NAFLD patients.

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“…There is large body evidence showing the association of HP and CLD (22)(23)(24)(25)(26). The prevalence of HP like DNA in the liver tissue samples of patients with CLD was significantly higher than the patients with metastatic adenocarcinoma (2).…”

Section: Discussion:-mentioning

confidence: 99%

Helicobacter Pylori Eradication Effect on Liver Fat Content in Patient With Non-Alcoholic Fatty Liver Disease.

Arnaout¹

2017

IJAR

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Association between Helicobacter pylori and liver-to-spleen ratio

Abstract: Liver-to-spleen ratio and the MPV-to-spleen ratio are important indices in the pathogenesis of H. pylori-linked liver and spleen manifestations, and thrombocytopenia.

Cited by 46 publications

References 20 publications

High‐fat diet‐ and angiotensin II‐induced aneurysm concurrently elicits splenic hypertrophy

High‐fat diet‐ and angiotensin II‐induced aneurysm concurrently elicits splenic hypertrophy

The Effect of Helicobacter Pylori Eradication on Liver Fat Content in Subjects With Non-Alcoholic Fatty Liver Disease: A Randomized Open-Label Clinical Trial

Helicobacter Pylori Eradication Effect on Liver Fat Content in Patient With Non-Alcoholic Fatty Liver Disease.

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