Association between Health-Related Quality of Life with Patient and Treatment Delays in Cancer Patients in Indonesia

Waren, Kalis; Vatvani, Akhil Deepak; Gunawan, C.; Phenca, Hans Keegan; Kurniawan, Andree

doi:10.1093/annonc/mdx621.069

Cited by 2 publications

(3 citation statements)

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“…Given the significant association between delayed time to treatment and inferior outcomes in several other cancer sites, we postulate that this is once again a reflection of the inability to overcome this strong selection bias in a retrospective design with a relatively small cohort 30–32. Although the association between delayed time to treatment and quality of life is understudied, it appears, as expected, to be associated with increased patient distress 33 34. Investigation of this metric’s impact on quality of life within different subpopulations and respective cultures and norms will probably be a fruitful addition to literature in light of the findings of this study and previous literature.…”

Section: Discussionmentioning

confidence: 92%

Disparities in time to start of definitive radiation treatment for patients with locally advanced cervical cancer

Williamson

Mell

Murphy

et al. 2022

Int J Gynecol Cancer

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BackgroundChemoradiation or radiation therapy alone are curative standards for patients with locally advanced cervical cancer.ObjectiveTo investigate factors that influence time to initiation of chemoradiation or radiation and the subsequent impact of time to treatment on recurrence and survival outcomes.MethodsPatients with locally advanced cervical cancer treated with definitive chemoradiation or radiation at our institution between November 2015 and August 2020 were retrospectively identified. Time to treatment initiation was defined as the number of days from date of diagnosis (via biopsy) to the start date of radiation. The cohort was stratified by the median time to treatment into early (<75 days) and delayed (≥75 days) cohorts. Multivariable logistic regression was conducted to examine factors associated with delayed time to treatment.ResultsWe identified 143 patients with locally advanced cervical cancer who underwent definitive chemoradiation or radiation. Median follow-up time was 18 months (range 2–62). A total of 71 (49.7%) patients had time to treatment <75 days and 72 (50.3%) patients had time to treatment ≥75 days. The delayed cohort had a higher proportion of Hispanic patients (51.4% vs 31.0%, p=0.04). In multivariable modeling, Hispanic women were 2.71 times more likely (p=0.04) to undergo delayed time to treatment than non-Hispanic white women. Additionally, patients with stage >IIB disease were less likely to undergo delayed time to treatment (OR 0.26, p=0.02) than patients with stage <IIB disease. There was no interaction between race/ethnicity and disease stage. Delayed time to treatment was not associated with inferior overall survival, loco-regional failure, or distant failure.ConclusionHispanic patients with locally advanced cervical cancer were more likely to receive delayed time to definitive treatment of ≥75 days. Further studies examining the presence of similar disparities in delay to definitive treatment for locally advanced cervical cancer at other institutions and settings are warranted.

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Section: Discussionmentioning

confidence: 92%

Disparities in time to start of definitive radiation treatment for patients with locally advanced cervical cancer

Williamson

Mell

Murphy

et al. 2022

Int J Gynecol Cancer

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“…This study found that 72.6% (95% CI; 68.9 to 76.1) of patients with cancer had a delay in health-seeking behaviour. The median (IQR) health-seeking interval was 6 months (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The most common reason for late presentation to health facilities was a lack of awareness about symptoms (49.78%) followed by ignorant of symptoms (29.8%), being busy going to the health centre (11.18%), embarrassment (5.9%) and others (3.34%).…”

Section: Magnitude Of Delay In Health-seeking Behaviour Among Adult P...mentioning

confidence: 99%

“…6 Patient delay is associated with overall health status, emotional functioning and symptoms such as fatigue and appetite loss. 7 The financial effect of cancer treatment may result in distress, feeling of guilt, worthlessness and loss of interest and pleasure in activity. 8 It is also distressing for the family and significantly affects both the family's daily functioning and economic situation.…”

Section: Introductionmentioning

confidence: 99%

Delay in health-seeking behaviour and associated factors among adult patients with cancer in Ethiopia: a multicentre cross-sectional study

Bayable,

Tegenaw,

Tesfaye

et al. 2023

BMJ Open

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ObjectivesDelays in obtaining proper cancer treatment can lead to advanced stages at diagnosis. Despite the problems, there is not enough evidence regarding delay in presentation. This study aims to assess delay in health-seeking behaviour and associated factors among adult patients with cancer in Ethiopia.DesignMulticentre cross-sectional study design.SettingData were collected from selected oncology centres in Ethiopia.ParticipantsA multistage sampling technique was used to select 635 study participants from May 9 to June 9 2022.Outcome measuresPatients who have a duration of ≥3 months from symptom recognition to the first healthcare visit were considered as delay in health-seeking behaviour. Data were entered using Epi data and exported to SPSS for further analysis. Before analysis, model fitness was carried out using Hosmer and Lemeshow test. Variables with a p value<0.25 in the bivariable analysis were included in multivariable logistic regression. In multivariable logistic regression, a p value<0.05 significant level was considered as the factor for delay in health-seeking behaviour.ResultsIn this study, a total of 628 adult patients with cancer participated. A total of 72.6% of patients had a delay in health-seeking behaviour. Variables such as being female (AOR=2.81; 95% CI=1.29 to 6.14), rural residence (AOR=2.82; 95% CI=1.43 to 5.58), low social support (AOR=4.16; 95% CI=2.04 to 8.49), not having comorbidity (AOR=4.44; 95% CI=2.28 to 8.66), stage III cancer (AOR=3.73; 95% CI=1.37 to 9.98), stage IV cancer (AOR=3.07; 95% CI=1.28 to 6.41), additional symptoms (AOR=3.03; 95% CI=1.55 to 5.94), never heard about cancers (AOR=4.09; 95% CI=2.06 to 8.11) and never heard about cancer screening (AOR=2.16; 95% CI=1.06 to 4.40) were identified as factors for delay in health-seeking behaviour.ConclusionThis study showed that relatively higher magnitude in which approximately three-fourth of adult patients with cancer were delayed in seeking medical attention. As a result, more effort must be made to tackle delay in health-seeking behaviour and associated factors.

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Association between Health-Related Quality of Life with Patient and Treatment Delays in Cancer Patients in Indonesia

Cited by 2 publications

References 0 publications

Disparities in time to start of definitive radiation treatment for patients with locally advanced cervical cancer

Disparities in time to start of definitive radiation treatment for patients with locally advanced cervical cancer

Delay in health-seeking behaviour and associated factors among adult patients with cancer in Ethiopia: a multicentre cross-sectional study

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