Association between hair cortisol concentration and metabolic syndrome

Mazgelytė, Eglė; Mažeikienė, Asta; Burokienė, Neringa; Matuzeviciene, Reda; Linkeviciute, Ausra; Kučinskienė, Zita Aušrelė; Karčiauskaitė, Dovilė

doi:10.1515/med-2021-0298

Cited by 5 publications

(16 citation statements)

References 48 publications

(60 reference statements)

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“…Two studies ( 55 , 57 ) found no significant associations, whereas two studies ( 51 , 66 ) found significant associations between UFC and MetS. Two studies ( 46 , 47 ) found significant associations between HCC and MetS. Four studies ( 46 , 48 , 60 , 64 ) found no significant association, whilst six studies ( 51 – 53 , 56 , 60 , 61 ) found significant associations between salivary cortisol and MetS.…”

Section: Resultsmentioning

confidence: 91%

“…Two studies ( 46 , 47 ) found significant associations between HCC and MetS. Four studies ( 46 , 48 , 60 , 64 ) found no significant association, whilst six studies ( 51 – 53 , 56 , 60 , 61 ) found significant associations between salivary cortisol and MetS. Six studies ( 46 , 49 , 54 , 58 , 63 , 65 ) found no significant associations, but four studies ( 51 , 58 , 59 , 66 ) found significant associations between serum cortisol and MetS.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies ( 46 , 48 , 60 , 64 ) found no significant association, whilst six studies ( 51 – 53 , 56 , 60 , 61 ) found significant associations between salivary cortisol and MetS. Six studies ( 46 , 49 , 54 , 58 , 63 , 65 ) found no significant associations, but four studies ( 51 , 58 , 59 , 66 ) found significant associations between serum cortisol and MetS. Two studies ( 50 , 55 ) found no significant associations, while three studies ( 62 , 63 , 66 ) found significant associations between DHEAS and MetS.…”

Section: Resultsmentioning

confidence: 99%

“…UFC (12-h or 24-h) was measured in four studies with chemiluminescence immunoassay ( 51 ), direct immunoenzymatic colorimetric method ( 55 ), high-performance chromatography ( 57 ), and electrochemiluminescence immunoassay ( 66 ). HCC was measured in two studies using enzyme-linked immunoassay ( 47 ) and high-performance chromatography ( 46 ). Salivary cortisol was measured in nine studies with enzyme-linked immunoassay ( 46 ), chemiluminescence immunoassay ( 51 , 60 , 64 ), radioimmunoassay (RIA) ( 48 , 52 , 61 ), electrochemiluminescence immunoassay ( 53 ), and competitive enzyme immunoassay ( 56 ).…”

Section: Assessment Heterogeneitymentioning

confidence: 99%

“…HCC was measured in two studies using enzyme-linked immunoassay ( 47 ) and high-performance chromatography ( 46 ). Salivary cortisol was measured in nine studies with enzyme-linked immunoassay ( 46 ), chemiluminescence immunoassay ( 51 , 60 , 64 ), radioimmunoassay (RIA) ( 48 , 52 , 61 ), electrochemiluminescence immunoassay ( 53 ), and competitive enzyme immunoassay ( 56 ). Serum cortisol was measured in eight studies with enzyme-linked immunoassay ( 46 , 49 , 51 , 54 , 65 ), RIA ( 58 , 59 ), and electrochemiluminescent immunoassay ( 66 ).…”

Section: Assessment Heterogeneitymentioning

confidence: 99%

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Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review

Osei

Block²,

Wippert³

2022

Front. Endocrinol.

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Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case–control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case–control studies. The included studies had a completeness of reporting score of COR % = 87.0 ± 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Assessment Heterogeneitymentioning

confidence: 99%

Section: Assessment Heterogeneitymentioning

confidence: 99%

See 3 more Smart Citations

Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review

Osei

Block²,

Wippert³

2022

Front. Endocrinol.

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Associations between hair cortisol and blood pressure: a systematic review and meta-analysis

Pageau

Ling

et al. 2023

Journal of Hypertension

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Objective:Stress is widely considered to be a risk factor for high blood pressure (BP), but evidence on the associations between biomarkers of chronic stress and BP is inconsistent. This systematic review and meta-analysis assessed the current state of the science on relationships between measures of cortisol concentration reflecting chronic stress exposure [hair cortisol concentration (HCC), nail cortisol concentration)] and BP.Methods:PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Cochrane Library, and Embase were searched. Random effects models were used to assess the pooled effect size. Exploratory moderation analysis was performed.Results:Out of 34 014 identified, 16 articles met eligibility criteria and were included in the review, while 14 were included in the meta-analysis. No articles were reported on the association between nail cortisol concentration and BP. Small, positive associations were observed between HCC and SBP [r = 0.19 (95% confidence interval (CI): 0.08–0.29)] and HCC and DBP [r = 0.13 (95% CI: 0.04–0.22)]. Cortisol analysis method was identified as a significant moderator of the association between HCC and DBP. HCC was largely, positively associated with hypertension status [odds ratio = 3.23 (95% CI: 2.55–4.09), P < 0.001].Conclusions:Current evidence suggests that higher HCC may be associated with elevated BP and a potential risk factor for hypertension. However, results should be interpreted with caution because HCC can be affected by hair color, hair care products, and analytic methods. Given the limitations of studies included in this review, further research is needed.

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Long‐term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta‐analysis

Kuckuck,

Lengton,

Boon

et al. 2023

J Intern Med

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The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long‐term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether the findings from the extreme glucocorticoid overabundance observed in Cushing's syndrome could be translated into more subtle variations in long‐term glucocorticoid levels among the general population, for example, due to chronic stress. Here, we performed a systematic review (PROSPERO: CRD42023425541) of evidence regarding the role of subtle variations in long‐term biological stress, measured as levels of scalp hair cortisol (HairF) and cortisone (HairE), in the context of MetS and CVD in adults. We also performed a meta‐analysis on the cross‐sectional difference in HairF levels between individuals with versus without CVD. Seven studies were included regarding MetS, sixteen regarding CVD, and one regarding both. Most articles indicated a strong, consistent cross‐sectional association of higher HairF and HairE levels with CVD, which was confirmed by our meta‐analysis for HairF (eight studies, SMD = 0.48, 95% confidence intervals [CIs]: 0.16–0.79, p = 0.0095). Moreover, these relationships appear largely independent of standard risk factors. Age seems relevant as the effect seems stronger in younger individuals. Results regarding the associations of HairF and HairE with MetS were inconsistent. Altogether, long‐term biological stress, measured as HairF and HairE, is associated with the presence of CVD, and less consistently with MetS. Prospective studies need to evaluate the directionality of this relationship and determine whether HairF and HairE can be used in addition to standard risk factors in predicting future cardiometabolic deterioration.

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Association between hair cortisol concentration and metabolic syndrome

Cited by 5 publications

References 48 publications

Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review

Association of primary allostatic load mediators and metabolic syndrome (MetS): A systematic review

Associations between hair cortisol and blood pressure: a systematic review and meta-analysis

Long‐term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta‐analysis

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