Association between gut microbiota and prediabetes in people living with HIV

Jayanama, Kulapong; Phuphuakrat, Angsana; Pongchaikul, Pisut; Prombutara, Pinidphon; Nimitphong, Hataikarn; Reutrakul, Sirimon; Sungkanuparph, Somnuek

doi:10.1016/j.crmicr.2022.100143

Cited by 6 publications

(13 citation statements)

References 63 publications

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“…These changes in composition extend even to those with prediabetes as described in a recent cross-sectional analysis of 40 PWH, 20 of whom had prediabetes and 20 who were normoglycaemic. This study found that alpha-diversity, or the measure of microbiome diversity applicable to a single sample, and beta-diversity, a measure of the similarity or dissimilarity of two communities, was significantly lower in PWH with prediabetes than in those with normoglycemia and that relative abundance of two genera in Firmicutes ( Streptococcus and Anaerostignum ) were significantly higher in the prediabetes group ( 11 ).…”

Section: Hiv and Microbiome Compositional Changesmentioning

confidence: 69%

HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway

MacCann

Landay

Mallon

2022

Current Opinion in HIV and AIDS

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Purpose of reviewThe purpose of this article is to review alterations in microbiota composition, diversity, and functional features in the context of chronic inflammation and comorbidities associated with HIV infection. Recent findingsThe gut microbiome is an important mediator of host immunity, and disruption of gut homeostasis can contribute to both systemic inflammation and immune activation. Ageing and HIV share features of intestinal damage, microbial translocation and alterations in bacterial composition that contribute to a proinflammatory state and development of age-related comorbidities. One such inflammatory pathway reviewed is the nicotinamide adenine dinucleotide (NADþ) producing kynurenine pathway (KP). Kynurenine metabolites regulate many biological processes including host-microbiome communication, immunity and oxidative stress and the KP in turn is influenced by the microbiome environment. Ageassociated decline in NADþ is implicated as a driving factor in many age-associated diseases, including those seen in people with HIV (PWH). Recent studies have shown that KP can influence metabolic changes in PWH, including increased abdominal adiposity and cardiovascular disease. Furthermore, KP activity increases with age in the general population, but it is elevated in PWH at all ages compared to agematched controls. Host or microbiome-mediated targeting of this pathway has merits to increase healthy longevity and has potential therapeutic applications in PWH. SummaryAs a growing proportion of PWH age, many face increased risks of developing age-related comorbidities. Chronic inflammation, a pillar of geroscience, the science of ageing and of age-related disease, is influenced by the gut microbiome and its metabolites. Combined, these contribute to a systemic inflammatory signature. Advances in geroscience-based approaches and therapeutics offer a novel paradigm for addressing age-related diseases and chronic inflammation in HIV infection. Whether targeted inhibition of KP activity alleviates pathological conditions or promotes successful ageing in PWH remains to be determined.

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Section: Hiv and Microbiome Compositional Changesmentioning

confidence: 69%

HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway

MacCann

Landay

Mallon

2022

Current Opinion in HIV and AIDS

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“…Emerging evidence suggests that gut dysbiosis may play a critical role in the development of diabetes [ 2 – 4 ]. Both our pilot study and other prior work have reported altered microbiota composition associated with some metabolic disorders, such as metabolic syndrome [ 5 ], prediabetes [ 6 ], and diabetes [ 7 ] among PLWH. However, these previous studies were limited by relatively small sample sizes, and characteristics of gut dysbiosis associated with diabetes in the context of HIV infection are not fully understood.…”

Section: Introductionmentioning

confidence: 77%

Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection

Luo,

Peters,

Moon

et al. 2024

Genome Med

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Background Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory responses in diabetes, particularly in the context of HIV infection, remains unclear. Methods We first conducted a cross-sectional association analysis to characterize the gut microbial, circulating metabolite, and immune/inflammatory protein features associated with diabetes in up to 493 women (~ 146 with prevalent diabetes with 69.9% HIV +) of the Women’s Interagency HIV Study. Prospective analyses were then conducted to determine associations of identified metabolites with incident diabetes over 12 years of follow-up in 694 participants (391 women from WIHS and 303 men from the Multicenter AIDS Cohort Study; 166 incident cases were recorded) with and without HIV infection. Mediation analyses were conducted to explore whether gut bacteria–diabetes associations are explained by altered metabolites and proteins. Results Seven gut bacterial genera were identified to be associated with diabetes (FDR-q < 0.1), with positive associations for Shigella, Escherichia, Megasphaera, and Lactobacillus, and inverse associations for Adlercreutzia, Ruminococcus, and Intestinibacter. Importantly, the associations of most species, especially Adlercreutzia and Ruminococcus, were largely independent of antidiabetic medications use. Meanwhile, 18 proteins and 76 metabolites, including 3 microbially derived metabolites (trimethylamine N-oxide, phenylacetylglutamine (PAGln), imidazolepropionic acid (IMP)), 50 lipids (e.g., diradylglycerols (DGs) and triradylglycerols (TGs)) and 23 non-lipid metabolites, were associated with diabetes (FDR-q < 0.1), with the majority showing positive associations and more than half of them (59/76) associated with incident diabetes. In mediation analyses, several proteins, especially interleukin-18 receptor 1 and osteoprotegerin, IMP and PAGln partially mediate the observed bacterial genera–diabetes associations, particularly for those of Adlercreutzia and Escherichia. Many diabetes-associated metabolites and proteins were altered in HIV, but no effect modification on their associations with diabetes was observed by HIV. Conclusion Among individuals with and without HIV, multiple gut bacterial genera, blood metabolites, and proinflammatory proteins were associated with diabetes. The observed mediated effects by metabolites and proteins in genera–diabetes associations highlighted the potential involvement of inflammatory and metabolic perturbations in the link between gut dysbiosis and diabetes in the context of HIV infection.

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“…Extraction of metagenomic DNA was performed using QIAamp® UCP Pathogen Mini Kit. The V3V4 hypervariable region of the 16 S rRNA gene was subsequently amplified by PCR and sequenced using the Miseq platform (250 base pairs, paired-end reads) (Illumina, Inc., USA), following the previously reported protocols, [16][17][18] at the Omics Sciences and Bioinformatics Center, Chulalongkorn University.…”

Section: Microbiome Evaluationsmentioning

confidence: 99%

Distinct skin microbiome modulation following different topical acne treatments in mild acne vulgaris patients: A randomized, investigator‐blinded exploratory study

Wongtada

Prombutara

Asawanonda

et al. 2023

Experimental Dermatology

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Acne vulgaris (AV), one of the most common skin diseases affecting adolescents and young adults, 1 develops from an interplay of multiple factors. Emerging data have shown that host-microbiome interactions play a critical role in AV pathogenesis. 2 In an equilibrium state, microorganisms residing on the skin and their surrounding environment form a complex community of skin microbiota, serving as a physical and immunological barrier to the skin. 3 When the balance of the microbial community is disrupted, dysbiosis of the skin flora occurs, leading to certain skin diseases 4 such as AV, and atopic dermatitis. 5 The loss of microbial diversity among commensal and

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Association between gut microbiota and prediabetes in people living with HIV

Cited by 6 publications

References 63 publications

HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway

HIV and comorbidities – the importance of gut inflammation and the kynurenine pathway

Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection

Distinct skin microbiome modulation following different topical acne treatments in mild acne vulgaris patients: A randomized, investigator‐blinded exploratory study

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