Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population

Ada, Ahmet Oğuz; Kunak, Semih C.; Hancer, Figen; Soydas, Emre; Alpar, Sibel; Gülhan, Meral; İşcan, Mümtaz

doi:10.1007/s11033-011-1411-0

Cited by 36 publications

(25 citation statements)

References 45 publications

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“…Their results revealed that no significant association was found for any of the analyzed polymorphisms and overall lung cancer risk, although their subgroup analysis revealed smoking-specific effects [48] . The latest study of a Turkish population showed that the GSTP1 exon 6 polymorphism (rs4891) may be an important factor in determining lung cancer susceptibility [49] . There is no risk genotype or allele for rs7208693, so it is difficult to evaluate the combination of GSTP1 and MPO with risk.…”

Section: Discussionmentioning

confidence: 99%

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

Feng

Mei

et al. 2014

Acta Pharmacol Sin

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Aim: Myeloperoxidase (MPO) and glutathione S-transferase pi 1 (GSTP1) are important carcinogen-metabolizing enzymes. The aim of this study was to investigate the association between the common polymorphisms of MPO and GSTP1 genes and lung cancer risk in Chinese Han population. Methods: A total of 266 subjects with lung cancer and 307 controls without personal history of the disease were recruited in this case control study. The tagSNPs approach was used to assess the common polymorphisms of MOP and GSTP1 genes and lung cancer risk according to the disequilibrium information from the HapMap project. The tagSNP rs7208693 was selected as the polymorphism site for MPO, while the haplotype-tagging SNPs rs1695, rs4891, rs762803 and rs749174 were selected as the polymorphism sites for GSTP1. The gene polymorphisms were confirmed using real-time PCR, cloning and sequencing. Results: The four GSTP1 haplotype-tagging SNPs rs1695, rs4891, rs762803 and rs749174, but not the MPO tagSNP rs7208693, exhibited an association with lung cancer susceptibility in smokers in the overall population and in the studied subgroups. When Phase 2 software was used to reconstruct the haplotype for GSTP1, the haplotype CACA (rs749174+rs1695 + rs762803+rs4891) exhibited an increased risk of lung cancer among smokers (adjust odds ratio 1.53; 95%CI 1. 04-2.25, P=0.033). Furthermore, diplotype analyses demonstrated that the significant association between the risk haplotype and lung cancer. The risk haplotypes co-segregated with one or more biologically functional polymorphisms and corresponded to a recessive inheritance model. Conclusion: The common polymorphisms of the GSTP1 gene may be the candidates for SNP markers for lung cancer susceptibility in Chinese Han population.

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Section: Discussionmentioning

confidence: 99%

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

Feng

Mei

et al. 2014

Acta Pharmacol Sin

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“…Table 3 shows no significant difference between TP53 and CYP2E1 gene interactions and the risk of NSCLC (top results). We then looked further to find if these variant genotypes would be associated with increased NSCLC risk if combined with the GSTM1, GSTT1, and GSTP1 polymorphisms from our earlier study (19) and found a significant association for TP53 codon72 Arg/Pro and Pro/ Pro in combination with the GSTM1 null genotypes. A similar significant association with NSCLC risk was found for the combinations of TP53 codon72 Arg/Pro and Pro/ Pro with the GSTT1 null and the GSTP1 (Ala114Val) genotypes (Table 3).…”

Section: Discussionmentioning

confidence: 99%

“…We have also analysed the interactions between TP53 and CYP2E1 gene polymorphisms and the GST gene (GSTM1, GSTT1 and GSTP1) polymorphisms that we had previously determined in the same patients in our 2012 study (19) to see whether they may affect the NSCLC risk. Our results confirm the findings of Klinchid et al (33), who found a significant association between the TP53 codon72 variant and GSTM1 null combination and NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…However, current findings on the overall impact of TP53, CYP2E1, and GST polymorphisms on NSCLC are limited and controversial (16)(17)(18). The aim of this study was to learn more about these impacts by investigating: a) the association between NSCLC risk and TP53 (Arg72Pro) and CYP2E1*5B polymorphisms either alone or in combination and b) possible gene interactions as risk modifiers for NSCLC by combining TP53 (Arg72Pro) and CYP2E1*5B polymorphisms with phase II enzyme coding gene polymorphisms GSTM1, GST1, GSTP1 (Ile105Val) (rs1695), and GSTP1 (Ala114Val) (rs1138272) that we have previously genotyped in NSCLC patients (19).…”

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confidence: 99%

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Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancer

Ada

Bilgen

Volkan

et al. 2016

Archives of Industrial Hygiene and Toxicology

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Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Genetic polymorphisms in tumour suppressor genes and genes encoding xenobiotic metabolising enzymes alter the activity of their corresponding enzymes and are important individual susceptibility factors for NSCLC. Because of the lack of information in literature, the aim of our study was to investigate the role of the tumour suppressor gene TP53 (Arg72Pro) and the xenobiotic metabolising CYP2E1*5B gene polymorphisms on the risk of NSCLC development. The study population consisted of 172 patients and 172 controls (156 men and 16 women in each group). Genetic polymorphisms were determined with real-time polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism (PCR-RFLP). Multivariate analysis showed a significant association with NSCLC for the combination between the TP53 codon72 Arg/Pro and the Pro/Pro genotypes (OR 2.21, 95 % CI 1.39-3.51; p=0.001). We also analysed whether combinations of these gene variants with GSTM1, GSTT1, GSTP1 exon 5 (Ile105Val), and GSTP1 exon 6 (Ala114Val) gene polymorphisms were associated with the NSCLC risk. A significant increase in the risk was observed for the following combinations: TP53 codon72 variant with GSTM1 null (OR 2.22, 95 % CI 1.23-4.04; p=0.009), GSTT1 null (OR 2.98, 95 % CI 1.49-5.94; p=0.002), and GSTP1 (Ala114Val) variant genotypes (OR 3.38, p=0.002). Further studies with larger samples are needed to verify these findings. KEY WORDS: carcinogen metabolism; CYP2E1; genetic polymorphism; GST; NSCLCLung cancer is the most common cancer type in the world, which affects men in particular. It is also the leading cause of death among cancers (1). Histologically, about 80 % of lung cancers are non-small cell lung carcinomas (NSCLC). The inbuilt phase I and II biotransformation enzyme systems inactivate environmental carcinogens, especially those present in tobacco smoke, depending on the regulating polymorphisms. Epidemiological studies show that genetic differences and interactions among genetic variants might modify lung cancer susceptibility (2, 3). Therefore, it is important to identify individual genetic and acquired factors that modify lung cancer risk in order to develop preventive strategies based on this information. This is particularly true for identifying polymorphisms of tumour suppressor genes and xenobiotic metabolising enzyme genes. The TP53 tumour suppressor gene is an essential regulator of the cell-cycle arrest, DNA repair, and apoptosis (4). An important single nucleotide polymorphism detected in TP53 is Arg72Pro. This allele has been shown to decrease the activity of the corresponding protein, which is crucial for the apoptotic function of TP53 (5, 6). Recent studies have reported the association between this polymorphism and lung cancer (7-11).CYP2E1 is an important phase I biotransformation enzyme that transforms N-nitrosamines, vinyl chloride, and benzene in tobacco smoke into mutagenic and carcinogenic metabolites (12). In NSCLC patients it has been fou...

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“…Zheng-Hui Hu, Yi-Wei Lin, Xin Xu, Hong Chen, Ye-Qing Mao, Jian Wu, Yi Zhu, Xiang-Lai Xu, Li-Ping Xie* McGrath et al, 2006), lung (Ada et al, 2012;Lopez-Cima et al, 2012), breast (Oliveira et al, 2010;de Aguiar et al, 2012), head and neck (Suzen et al, 2007;Nosheen et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

Lin²,

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population

Cited by 36 publications

References 45 publications

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

HapMap-based study on the association between MPO and GSTP1 gene polymorphisms and lung cancer susceptibility in Chinese Han population

Association between the TP53 and CYP2E1*5B gene polymorphisms and non-small cell lung cancer

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

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