Association between greenness and dyslipidemia in patients with coronary heart disease: A proteomic approach

Guo, Jianhui; Wu, Jieyu; Wei, Donghong; Ting-gui, Wang; Hu, Yuduan; Lin, Ya-Wen; Chen, Mingjun; Yang, Le; Wen, Yeyin; Cai, Yingying; Xu, Xingyan; Li, Huanyuan; Wu, Siying; Xie, Xiaoxu

doi:10.1016/j.ecoenv.2022.113199

Cited by 6 publications

(5 citation statements)

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“…A protective effect of greenness exposure on dyslipidemia has also been found. The Hypothesis 2, that exposure to greenness is associated with dyslipidemia, was supported and is consistent with previous work [ 20 , 21 , 67 ]. Although our study estimated the association between greenness exposure and dyslipidemia at city level, our findings may also support those studies that focused on the community level [ 20 , 21 , 67 ].…”

Section: Discussionsupporting

confidence: 90%

“…The Hypothesis 2, that exposure to greenness is associated with dyslipidemia, was supported and is consistent with previous work [ 20 , 21 , 67 ]. Although our study estimated the association between greenness exposure and dyslipidemia at city level, our findings may also support those studies that focused on the community level [ 20 , 21 , 67 ]. For example, in a previous study of a Chinese elderly population, Shujun Fan reported that those who were surrounded by more greenness may have a lower level of TG and higher level of HDL-C, indicating a beneficial association between greenness exposure and dyslipidemia [ 20 ].…”

Section: Discussionsupporting

confidence: 90%

“…Other than socioeconomic factors, broadly defined contextual factors, which entail the built environment, water abundance, and greenness exposure, may also exert influence on dyslipidemia [ 19 , 20 ]. Among those, an extensive body of work suggest that adults living in a low-greenness environment were more likely to have a high prevalence of dyslipidemia than their counterparts living in a high-greenness environment [ 21 , 22 ], indicating a beneficial association between greenness and dyslipidemia [ 23 ]. In other words, a protective effect of greenness exposure on dyslipidemia has generally been found [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Psychological Burden on Dyslipidemia Moderated by Greenness: A Nationwide Study from China

Liu

et al. 2022

IJERPH

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Globally, dyslipidemia is now become a leading risk factor for many adverse health outcomes, especially in the middle-aged and elderly. Recent evidence suggests that exposure to greenness and the relief of a psychological burden may decrease the prevalence of dyslipidemia. The objective of our study was to examine whether a green space can moderate the association between mental health status and dyslipidemia. Our study selected the datasets of depression symptoms, dyslipidemia from the China Health and Retirement Longitudinal Study (CHARLS), and the satellite-based normalized difference vegetation index (NDVI) from the 30 m annual maximum NDVI dataset in China in 2018. Ultimately, a total of 10,022 middle-aged and elderly Chinese were involved in our study. Multilevel logistic regressions were performed to examine the association between symptoms of depression and dyslipidemia, as well as the moderate effect of greenness exposure on the association. Our research suggested that adults diagnosed with depression symptoms were more likely to suffer from dyslipidemia. In addition, the NDVI was shown to moderate the effect of depression on dyslipidemia significantly, though the effect was attenuated as depression increased. Regarding the moderate effect of the NDVI on the above association across age, gender, and residence, the findings presented that females, the elderly, and respondents living in urban areas were at a greater risk of having dyslipidemia, although the protective effect of the NDVI was considered. Likewise, the moderate effect of the NDVI gradually decreased as the level of depression increased in different groups. The current study conducted in China provides insights into the association between mental health, green space, and dyslipidemia. Hence, improving mental health and green spaces can be potential targets for medical interventions to decrease the prevalence of dyslipidemia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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The Effect of Psychological Burden on Dyslipidemia Moderated by Greenness: A Nationwide Study from China

Liu

et al. 2022

IJERPH

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“…Many previous studies have shown that lipid metabolism is related to many biological functions, being essential for many biochemical reactions ( 32 ). It has been found that the levels of unsaturated fatty acids (e.g., linoleic acid and arachidonic acid) were significantly down-regulated in a high-fat-induced model group, suggesting enhanced peroxidation and oxidative stress ( 33 ).…”

Section: Resultsmentioning

confidence: 99%

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

et al. 2023

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ObjectiveIn this study, the structure of Pleurotus eryngii polysaccharides (PEPs) was characterized, and the mechanism of PEP on obesity and hyperlipidemia induced by high-fat diet was evaluated by metabonomic analysis.MethodsThe structure of PEPs were characterized by monosaccharide composition, Fourier transform infrared spectroscopy and thermogravimetry. In animal experiments, H&E staining was used to observe the morphological difference of epididymal adipose tissue of mice in each group. Ultrahigh performance liquid chromatography (UHPLC)-(QE) HFX -mass spectrometry (MS) was used to analyze the difference of metabolites in serum of mice in each group and the related metabolic pathways.ResultsThe PEPs contained nine monosaccharides: 1.05% fucose, 0.30% arabinose, 17.94% galactose, 53.49% glucose, 1.24% xylose, 23.32% mannose, 1.30% ribose, 0.21%galacturonic acid, and 1.17% glucuronic acid. The PEPs began to degrade at 251°C (T0), while the maximum thermal degradation rate temperature (Tm) appeared at 300°C. The results histopathological observation demonstrated that the PEPs had signifificant hypolipidemic activities. After PEPs intervention, the metabolic profile of mice changed significantly. A total of 29 different metabolites were selected as adjunctive therapy to PEPs, for treatment of obesity and hyperlipidemia-related complications caused by a high-fat diet. These metabolites include amino acids, unsaturated fatty acids, choline, glycerol phospholipids, and other endogenous compounds, which can prevent and treat obesity and hyperlipidemia caused by a high-fat diet by regulating amino acid metabolism, fatty acid metabolism, and changes in metabolic pathways such as that involved in the citric cycle (TCA cycle).ConclusionsThe presented results indicate that PEPs treatment can alleviate the obesity and hyperlipidemia caused by a high-fat diet and, thus, may be used as a functional food adjuvant, providing a theoretical basis and technical guidance for the prevention and treatment of high-fat diet-induced obesity and hyperlipidemia.

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“…30 In addition, results of several studies show that older adults living in greener neighborhoods have better lipid profiles, [31][32][33] and there is indication that this may be related to changes in proteins that regulate lipid metabolism and transport. 34 Why surrounding greenspaces affect lipid metabolism, or for that matter, blood pressure or glucose homeostasis remains unknown.…”

Section: Association Of Greenspaces With Cardiovascular Disease Morbi...mentioning

confidence: 99%

Greenspaces And Cardiovascular Health

Keith,

Hart,

Bhatnagar

2024

Circulation Research

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Accumulating evidence suggests that living in areas of high surrounding greenness or even brief exposures to areas of high greenery is conducive to cardiovascular health, which may be related to the environmental, social, psychological, and physiological benefits of greenspaces. Recent data from multiple cross-sectional, longitudinal, and cohort studies suggest that living in areas of high surrounding greenness is associated with a lower risk of all-cause and cardiovascular mortality. High levels of neighborhood greenery have been linked also to a decrease in the burden of cardiovascular disease risk factors as reflected by lower rates of hypertension, dyslipidemia, and diabetes. Those who live in greener environments report better mental health and more frequent social interactions, which can benefit cardiovascular health as well. In this narrative review, we discuss evidence linking greenspaces to cardiovascular health as well as the potential mechanisms underlying the beneficial effects of greenspaces, including the impact of vegetation on air, noise and light pollution, ambient temperature, physical activity, mental health, and biodiversity. We review literature on the beneficial effects of acute and chronic exposure to nature on cardiovascular disease risk factors, inflammation and immune function, and we highlight the potential cardiovascular effects of biogenic volatile organic compounds that are emitted by trees and shrubs. We identify current knowledge gaps in this area and underscore the need for additional population studies to understand more clearly and precisely the link between greenness and health. Such understanding is urgently needed to fully redeem the promise of greenspaces in preventing adverse environmental exposures, mitigating the effects of climate change, and creating healthier living environments.

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Association between greenness and dyslipidemia in patients with coronary heart disease: A proteomic approach

Cited by 6 publications

References 68 publications

The Effect of Psychological Burden on Dyslipidemia Moderated by Greenness: A Nationwide Study from China

The Effect of Psychological Burden on Dyslipidemia Moderated by Greenness: A Nationwide Study from China

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

Greenspaces And Cardiovascular Health

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