Association between gray/white matter contrast and white matter microstructural alterations in medication-naïve obsessive–compulsive disorder

Niu, Qihui; Li, Jianyu; Yang, Lei; Huang, Zitong; Niu, Mingmin; Song, Xueqin; Zhang, Yuanchao; Li, Youhui

doi:10.1016/j.nicl.2022.103122

Cited by 2 publications

(1 citation statement)

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“…A combination meta‐analysis has demonstrated that OCD patients have substantial decreases in the left superior frontal gyrus, right gyrus rectus, right cerebellar hemispheric lobule, and left superior longitudinal fasciculus. A meta‐analysis of WM study results indicated that OCD patients were associated with higher FAs in the right lenticular nucleus than healthy controls, as well as lower FAs in the left insula, right cerebellum, right rectal gyrus, and left inferior parietal gyri compared with healthy controls (Niu et al, 2022 ). Based on subgroup analyses, there was a significant difference in FA changes between TBSS and VBA in OCD patients compared with healthy controls (Tao et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between white matter alterations and contamination subgroup in obsessive compulsive disorder: A diffusion tensor imaging study

Damirichi

Moridani

Mohammadi

2023

Human Brain Mapping

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Approximately 2%–3% of the world population suffers from obsessive–compulsive disorder (OCD). Several brain regions have been involved in the pathophysiology of OCD, but brain volumes in OCD may vary depending on specific OCD symptom dimensions. The study aims to explore how white matter structure changes in particular OCD symptom dimensions. Prior studies attempt to find the correlation between Y‐BOCS scores and OCD patients. However, in this study, we separated the contamination subgroup in OCD and compared directly to healthy control to find regions that exactly related to contamination symptoms. To evaluate structural alterations, diffusion tensor imaging was acquired from 30 OCD patients and 34 demographically matched healthy controls. Data were processed using tract‐based spatial statistics (TBSS) analysis. First, by comparing all OCD to healthy controls, significant fractional anisotropy (FA) decreased in the right anterior thalamic radiation, right corticospinal tract, and forceps minor observed. Then by comparing the contamination subgroup to healthy control, FA decreases in the forceps minor region. Consequently, forceps minor plays a central role in the pathophysiology of contamination behaviors. Finally, other subgroups were compared to healthy control and discovered that FA in the right corticospinal tract and right anterior thalamic radiation is reduced.

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Section: Introductionmentioning

confidence: 99%