Association between glutathione S‐transferase π polymorphisms and survival in patients with advanced nonsmall cell lung carcinoma

Abstract

Deafferentation of the auditory nerve from loss of sensory cells is associated with degeneration of nerve fibers and spiral ganglion neurons (SGN). SGN survival following deafferentation can be enhanced by application of neurotrophic factors (NTF), and NTF can induce the regrowth of SGN peripheral processes. Cochlear prostheses could provide targets for regrowth of afferent peripheral processes, enhancing neural integration of the implant, decreasing stimulation thresholds, and increasing specificity of stimulation. The present study analyzed distribution of afferent and efferent nerve fibers following deafness in guinea pigs using specific markers (parvalbumin for afferents, synaptophysin for efferent fibers) and the effect of brain derived neurotrophic factor (BDNF) in combination with acidic fibroblast growth factor (aFGF). Immediate treatment following deafness was compared with 3‐week‐delayed NTF treatment. Histology of the cochlea with immunohistochemical techniques allowed quantitative analysis of neuron and axonal changes. Effects of NTF were assessed at the light and electron microscopic levels. Chronic BDNF/aFGF resulted in a significantly increased number of afferent peripheral processes in both immediate‐ and delayed‐treatment groups. Outgrowth of afferent nerve fibers into the scala tympani were observed, and SGN densities were found to be higher than in normal hearing animals. These new SGN might have developed from endogenous progenitor/stem cells, recently reported in human and mouse cochlea, under these experimental conditions of deafferentation‐induced stress and NTF treatment. NTF treatment provided no enhanced maintenance of efferent fibers, although some synaptophysin‐positive fibers were detected at atypical sites, suggesting some sprouting of efferent fibers. J. Comp. Neurol. 507:1602–1621, 2008. © 2008 Wiley‐Liss, Inc.

Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer

“…Polymorphisms of GSTP1 have been associated with platinum-based chemotherapy efficacy in colon, 22 lung [23][24][25] and gastric cancer, 26 revealing their clinical potential as a biomarker to predict platinum-related chemosensitivity. In our study, we observed an association of GSTP1 rs1695 GA þ GG genotypes with tumor sizes >5 cm, but an association with overall survival was not observed.…”

Association of GSTP1 and RRM1 Polymorphisms with the Response and Toxicity of Gemcitabine-cisplatin Combination Chemotherapy in Chinese Patients with Non-small Cell Lung Cancer

“…Previous studies have also suggested the importance of the allelic status of GSTP1 for platinum metabolism. It is showed that at codon 105 the variants of the enzymes with valine (Val) have higher activity against cisplatin and carboplatin than enzymes with isoleucine (Ile), and hence polymorphic Ile105Val of GSTP1 is linked to the sensitivity of cancer cells to platinum (Booton et al, 2006;Lu et al, 2006;Peklak-Scott et al, 2008).…”

Role of GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms in the response to chemotherapy and overall survival of advanced non-small cell lung cancer

“…Several previous studies have reported associations between the GSTM1, GSTT1, and GSTP1 IIe105Val gene polymorphisms and patient outcomes, but the results are inconclusive (Lu et al, 2006;Booton et al, 2006;Kalikaki et al, 2009;Ada et al, 2010;Yang and Xian, 2014;Liu et al, 2015). Booton et al (2006) reported that the GSTP1 IIe105Val polymorphism was correlated with the response and survival of NSCLC patients.…”