Association between Glutathione S-Transferase T1 Null Genotype and Gastric Cancer Risk: A Meta-Analysis of 48 Studies

Ma, Wenxue; Liu, Zhuang; Han, Bo; Tang, Bo

doi:10.1371/journal.pone.0060833

Cited by 9 publications

(4 citation statements)

References 54 publications

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“…GSTM1 and GSTT1 null genotypes were associated with statistically significant increased risk in recent meta-analyses that include Asian studies. 11,12 In our study, the point estimates of ORs for GSTM1 and GSTT1 null genotypes on the gastric cancer risk were above unity, which was similar to those of previous studies.…”

Section: Discussionsupporting

confidence: 90%

“…9,10 In recent several metaanalyses, GSTM1 and GSTT1 null genotypes, which cannot detoxify reactive carcinogens, were associated with increased risk of gastric cancer. 11,12 Although the association between CYP1A1 (rs4646903 and rs1048943) polymorphisms, which are common single nucleotide polymorphisms (SNPs), and gastric cancer risk was not found, 13,14 another study showed that CYP1A1 (rs4646903) mutational heterozygous genotype was associated with a statistically significant increased risk compared with wild genotype among large sample size studies only. 15 Most individual studies in these meta-analyses and recently published studies are retrospective, and their sample sizes are small.…”

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confidence: 99%

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CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Hidaka¹,

Sasazuki²,

Matsuo

et al. 2016

Intl Journal of Cancer

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Cytochrome P450 (CYP) 1A1 and glutathione S-transferases (GST) M1 and T1 are major enzymes in the carcinogen metabolizing pathway. We examined the association between single nucleotide polymorphisms (SNPs) of CYP1A1 (rs4646421, rs4646422 and rs1048943), GSTM1 and GSTT1 and gastric cancer risk in Japan. This is a nested case-control study (457 cases and 457 matched controls) of our population-based cohort involving 36,745 subjects who answered a baseline questionnaire and supplied blood samples. The odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated using conditional logistic regression models. We found that CYP1A1 (rs4646422) variant allele was associated with a statistically significant increased risk of gastric cancer compared with the homozygous wild-type genotype (OR 5 1.65; 95% CI 5 1.17-2.32). GSTM1 null, GSTT1 null and GSTM1/T1 both or either null genotypes were associated with increased risk, but not statistically significantly. Combination of the CYP1A1 (rs4646422) variant allele and GSTM1/T1 both or either null genotypes was associated with a statistically significant increased risk compared with the combination of the CYP1A1 homozygous wild-type genotype and the GSTM1/T1 both active genotypes. In addition, compared with CYP1A1 (rs4646422) homozygous wild-type genotypes in those who were never-smokers, CYP1A1 variant alleles in those who smoked 30 pack-years were associated with an increased risk; neither gene-gene nor gene-environment interactions were significant. The CYP1A1 (rs4646422) polymorphism might be involved in gastric carcinogenesis among the Japanese population.According to the International Agency for Research on Cancer, tobacco is classified as a carcinogenic agent; sufficient evidence of this exists in humans.1 Tobacco contains multiple chemical substances such as polycyclic aromatic hydrocarbons (PAHs), N-nitrosamines and heterocyclic amines. 2PAHs are also contained in polluted air (exhaust fumes) 3 and grilled food, 4 among others. The carcinogenetic effect of exposure to PAH was reported in in vivo and in vitro studies. 5 In a recent prospective study, higher concentrations of 1-hydroxypyrene glucuronide, which is a PAH metabolite, were associated with increased risk of gastric cancer among Chinese individuals.

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Section: Discussionsupporting

confidence: 90%

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confidence: 99%

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Hidaka¹,

Sasazuki²,

Matsuo

et al. 2016

Intl Journal of Cancer

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“…It is known that deletions in GSTM1 and GSTT1 genes is associated with reduced or absence of enzyme activity (Hallier et al 1993 ). Moreover, numerous studies have shown the link between the lack of enzyme activity in GSTM1 and GSTT1 and the susceptibility to develop various types of cancer, such as oral cancer, gastric cancer, bladder cancer, and CML in different ethnical groups worldwide (Bajpai et al 2007 ; Sharma et al 2013 ; Dunna et al 2013 ; Ma et al 2013 ; Dong et al 2013 ; Bhat et al 2012 ). Furthermore, other studies have found an association between GSTM1 and GSTT1 deletions and the response to chemotherapy, such as disease free survival, overall survival or toxicity (Voso et al 2002 ; Mossallam et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Association of glutathione S-transferase (GSTM1 and GSTT1) genes with chronic myeloid leukemia

et al. 2015

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Chronic myeloid leukemia (CML), as most of cancers results from a complex interaction between genetic or non genetic factors. Exposures to xenobiotics endogenous or exogenous associated with a reduced individual ability in detoxifying activity, constitutes a risk of developing cancer. It is known that polymorphism of glutathione S-transferases (GSTs) genes affects the detoxification of xenobiotics. Thus, we conducted a case-control study in which 92 patients (Mean age ± SD, 40.62 ± 12.7 years) with CML and 93 healthy unrelated controls (Mean age ± SD, 41.38 ± 13.4 years) have participated. GSTM1 and GSTT1 genotypes were determined by multiplex polymerase chain reaction. Logistic regression was used to assess the possible link between GSTM1 and GSTT1 null genotypes and CML as well as between combined genotypes and CML. GSTM1 null genotype frequency was slightly higher in patients than control (48.9% vs. 40.9%) but, it was not associated with CML (OR 95% CI, 1.4, 0.78-2.48; p = 0.271). Moreover, GSTT1 null genotype frequency showed a similar trend between patients and control (17.4% vs. 9.7%; OR 95% CI, 1.97, 0.82-4.71; p = 0.13). Surprisingly, GSTT1 null genotype was significantly associated with the risk of CML in males (OR 95% CI, 5, 1.25-20.1; p = 0.023). The combined GSTM1 present/GSTT1 null genotype was found to have a limited effect against the risk of CML (OR 95% CI, 0.3, 0.08-0.99; p = 0.049). Our findings have shown that GSTT1 null genotype might be a risk factor of CML in males. While, GSTT1 present genotype might be considered as protective against CML. However, further studies with a large sample size are needed to confirm our findings.

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“…The frequencies of homozygous deletions of GSTT1 gene are higher in Asians and Africans than in Caucasians], whereas homozygous deletions of GSTM1 gene are higher in Caucasians and Asians than in Africans (12,13) . Moreover, numerous studies have evaluated the association between polymorphisms of GSTs gene and the susceptibility to develop various types of cancer, such as gastric cancer, oral cancer, bladder cancer, and chronic myeloid leukemia CML in different ethnical groups worldwide (14)(15)(16)(17) . Furthermore, other studies have found an association between GSTM1 and GSTT1 deletions and disease susceptibility, drug response and resistance to chemotherapy treatment (18)(19)(20) .…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

2016

IJMS

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Background Glutathione S-transferases (GSTs) are enzymes of Phase II, which play an important role in cellular detoxification by conjugation of reduced glutathione with a wide variety of potentially toxic and carcinogenic. Polymorphisms of genes coding for the glutathione S-transferase (GST) enzymes were known to be associated with susceptibility to various forms of cancer, or outcome of multichemotherapeutic regimens. Objective To analyze of the frequencies of the major polymorphisms of the GSTM1 and GSTT1 in Baghdad population to provide a basic database for future genetic and clinical studies. Methods Peripheral blood was obtained from 142 healthy individuals randomly selected from two districts in Baghdad. The age of studied participants ranges from 15-46 yeares at time of inclusion. Genomic DNA was isolated from leukocytes using Wizerd genomic DNA purification kit. The GSTT1 and GSTM1 gene polymorphism were evaluated using multiplex polymerease chain reaction in which albumen gene was used as internal controls. Results Twenty nine individuals (20.4%) revealed no amplification of the GSTT1 gene (null type). The null GSTM1 genotype was found in 66.2% (94 individuals). Twelve percent (17/142) had null genotype for both genes. The most frequently observed genotype was GSTT1 positive/GSTM1 null genotype (54.2%) while the GSTT1 null/GSTM1 positive genotype observed in 12 individuals (8.5%). GSTT1postive/GSTM1 positive genotype was found in 36 (25.4%) of the sample study. Conclusion Data of the present study showed that the frequency of GSTT1 and GSTM1null genotype of the sample study is in concordance with those documented for Caucasian, Asians, and Arabs population. This study provides information for frequency distribution of GSTT1and GSTM1 null genotypes in the Baghdad population and information about genetic difference between Iraqi individuals and other population that provide basis for future genetics and clinical studies.

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Association between Glutathione S-Transferase T1 Null Genotype and Gastric Cancer Risk: A Meta-Analysis of 48 Studies

Cited by 9 publications

References 54 publications

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case–control study within a large‐scale population‐based prospective study

Association of glutathione S-transferase (GSTM1 and GSTT1) genes with chronic myeloid leukemia

Genetic Polymorphism of the Glutathione S-Transferase M1 and T1 Genes in Baghdad Population

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