Association between genetically proxied PCSK9 inhibition and systemic lupus erythematosus risk: A mendelian randomization study
Xincan Ji,
Hao‐Yang Guo,
Mengqi Han
et al.
Abstract:BackgroundPreclinical and epidemiological studies suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) had a potential effect on the development of SLE, but it was unclear whether a causal relationship exists. We aimed to investigate the association between genetically proxied inhibition of PCSK9 and the risk of SLE using a two‐sample Mendelian randomization (MR) approach.MethodsSingle nucleotide polymorphisms (SNPs) associated with PCSK9 were extracted from pooled data obtained from the Global L… Show more
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