Association between genetic variants in PNPLA3 and serum adiponectin

Patatin‐like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages

“…16 While serum vaspin, fibroblast growth factor-21, chemerin, adipocyte fatty acid-binding protein and progranulin levels were not affected, rs738409 correlated negatively with adiponectin levels. 16 Probably, insulin-sensitising effects of adiponectin may be involved. 17 On the other hand, the association of rs738409 with low adiponectin levels may only be an epiphenomenon because visceral obesity, which is frequently present in rs738409 NAFLD patients, causes low serum adiponectin levels.…”

“…Non‐alcoholic fatty liver disease promoting effects of rs738409 might also be caused by effects of this polymorphism on adipocyte's cell size, and on adipokine synthesis . While serum vaspin, fibroblast growth factor‐21, chemerin, adipocyte fatty acid‐binding protein and progranulin levels were not affected, rs738409 correlated negatively with adiponectin levels . Probably, insulin‐sensitising effects of adiponectin may be involved .…”

“…Probably, insulin‐sensitising effects of adiponectin may be involved . On the other hand, the association of rs738409 with low adiponectin levels may only be an epiphenomenon because visceral obesity, which is frequently present in rs738409 NAFLD patients, causes low serum adiponectin levels …”

“…17 On the other hand, the association of rs738409 with low adiponectin levels may only be an epiphenomenon because visceral obesity, which is frequently present in rs738409 NAFLD patients, causes low serum adiponectin levels. 16 Herein, we aim to investigate the influence of the rs738409 variant of the PNPLA3 gene on adult and adolescent overweight/obese subjects with and without MetS.…”

Association of genetic variants with non‐alcoholic fatty liver disease in an urban Sri Lankan community

“…We selected 10 single nucleotide polymorphisms (SNPs) for a case-control replication study; five SNPs had been previously identified to be associated with NAFLD and related phenotypes at a genome-wide significance level (P ≤ 5 9 10 À8 ) in European GWA studies [PNPLA3 (rs738409), LYPLAL1 (rs12137855), GCKR (rs780094), PPP1R3B (rs4240624) and NCAN (rs2228603)] (5, 7), and the remaining five SNPs were derived from three previously documented candidate genes for NAFLD [APOC3 (rs2854117, rs2854116), ADIPOR2 (rs767870) and STAT3 (rs6503695, rs9891 119)] (8)(9)(10). The genotype distribution of all tested SNPs was in Hardy-Weinberg equilibrium (P > 10 À3 ).…”