Association between genetic risk score and periodontitis onset and progression: A pilot study

Ricci, Massimiliano; Garoia, Flavio; Tabarroni, Cristiano; Marchisio, O; Barone, Antonio; Genovesi, Anna Maria; Covani, Ugo

doi:10.1016/j.archoralbio.2011.07.002

Cited by 19 publications

(15 citation statements)

References 21 publications

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“…Present data regarding TNF-α SNP association with periodontitis are in accordance with other case-controls investigations [15,16] and support a role for TNF-α in chronic inflammation and bone remodeling, as shown for different diseases such as rheumatoid arthritis [31]. …”

Section: Discussionsupporting

confidence: 90%

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Variations in inflammatory genes are associated with periodontitis

Ianni

Bruzzesi²,

Pugliese³

et al. 2013

Immun Ageing

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BackgroundPeriodontitis is a multi-factorial disease and several risk-factors such as infections, inflammatory responses, oral hygiene, smoke, aging and individual predisposition are involved in the disease. Pathogens trigger chronic inflammation with cytokines release which in turn leads to the destruction of the connective and the teeth supporting bone. The identification of genetic factors controlling oral inflammation may increase our understanding of genetic predisposition to periodontitis.Single nucleotide polymorphisms in the promoter region of Vascular Endothelial Growth Factor, Alpha-1-Antichymotripsin, hydroxy-methyl-glutaryl CoA reductase, Interferon alpha, Interleukin-1 Beta, Interleukin 10, Interleukin 6 and Tumor Necrosis Factor- alpha genes from a case/control study were investigated.ResultsThe C allele of Vascular Endothelial Growth Factor, A allele of Interleukin 10 and GG genotype of Tumor Necrosis Factor-α were individually associated with chronic periodontitis. However, the concomitant presence of the three genetic markers in the same subjects appeared to play a synergistic role and increased several folds the risk of the disease.ConclusionsOur findings offer new tools to implement the screening of unaffected subjects with an increased susceptibility of periodontitis and increase our understanding regarding the genetic inflammatory background related to familiarity of the disease.

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Section: Discussionsupporting

confidence: 90%

“…A strong association between Tumor Necrosis Factor Alpha (TNF-α) rs1800629 and generalized forms of periodontitis was found [15]. A TNF-α promoter SNP (-308) has also been associated with the development of the disease and aggressive periodontitis [16].…”

Section: Introductionmentioning

confidence: 99%

Variations in inflammatory genes are associated with periodontitis

Ianni

Bruzzesi²,

Pugliese³

et al. 2013

Immun Ageing

View full text Add to dashboard Cite

show abstract

“…Although individually the impact of any one genotype on risk is modest, it has been suggested that when such risk-genotypes are common their combination may have a strong predictive power [29]. Several studies demonstrated that the aggregation of the contribution of multiple SNPs, selected from both candidate genes and genes identified through large-scale genomic association studies, into a single Genetic Risk Score (GRS) significantly increases the prediction power of the susceptibility to develop complex diseases like cardiovascular disease, type II diabetes, periodontitis or psoriasis [30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Genetic Customization of Anti-aging Treatments

Nisticò¹,

Duca²,

Garoia³

2018

J Clin Exp Dermatol Res

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Skin aging is a multifactorial process that involves both intrinsic factors of genetic and hormonal origin and extrinsic factors of environmental and nutritional nature.The purpose of this open study on a case series of volunteers is to evaluate the impact of genetic customization of common anti-aging dermocosmetic treatments. We report how the treatment may be customized by acting selectively on the metabolic impairments identified by the analysis of specific DNA variants. The customized cosmetic method shows a significantly higher efficacy compared to non-specific cosmetic treatments such as radiofrequency, suggesting that the combination genetic signature may provide a useful tool for personalized and more effective anti-aging therapies.

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“…With only partially known receptors and coreceptors, their overall roles remain to be described in detail but are likely to be fairly complex judging from the known signalling networks related of IL-1B [9]. The observed frequencies of IL-1B (3954) genotype CC (Table 2) were clearly higher (more than 90%) in this work for Indonesian male adults than what has been reported previously for European subjects [15]. …”

Section: Discussionmentioning

confidence: 55%

CRP and IL-1B Gene Polymorphisms and CRP in Blood in Periodontal Disease

Auerkari¹,

Suhartono²,

Djamal³

et al. 2013

TODENTJ

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Recent studies have suggested an association between periodontal disease (PD) and the systemic polygenic diseases such as cardiovascular disease (CVD). These are thought to be associated because of interrelated environmental, epigenetic, and genetic risk factors. The involved candidate genes include the IL-1B gene, encoding the pro-inflammatory cytokine IL-1β, and the CRP gene encoding the C-reactive protein (CRP), also a known marker of inflammation. However, as the details are not well known on the genetic variation influencing the risk factors, this work aimed to evaluate the distribution of selected polymorphisms of IL-1B and CRP genes, and serum CRP level, in comparison with the PD status. For this purpose, periodontal health was assessed, serum CRP levels measured and polymorphism status of IL-1B and CRP genes determined from samples of peripheral blood taken from 101 consenting Indonesian adult males. The results show that severe PD was significantly associated with age and smoking, as expected, but not with the polymorphisms of IL-1B or CRP (1444). However, a significantly lower fraction of subjects with normal periodontal health than subjects with PD showed the heterozygous type polymorphism of CRP (717). There was no significant difference in the fraction of cases with elevated serum CRP level between subjects with normal health and those with PD, and further study with a larger sample is recommended. The observed association between polymorphism of CRP (717) and periodontal health is suggested as a complementary indicator of the risk to PD for the Indonesian male population.

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Association between genetic risk score and periodontitis onset and progression: A pilot study

Cited by 19 publications

References 21 publications

Variations in inflammatory genes are associated with periodontitis

Variations in inflammatory genes are associated with periodontitis

Genetic Customization of Anti-aging Treatments

CRP and IL-1B Gene Polymorphisms and CRP in Blood in Periodontal Disease

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