Association between genetic polymorphisms of inflammatory response genes and the risk of ovarian cancer

Lu, Zhonghua; Gu, Xijuan; Shi, Ke-Zhi; Li, Xuan; Chen, Dian-Dian; Chen, Li

doi:10.1016/j.jfma.2015.01.002

Cited by 14 publications

(10 citation statements)

References 31 publications

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“… 41 conducted their research in two different places (eastern and southern china), which were treated as four individual comparisons. Therefore, a total of 42 studies from 36 articles were identified, including 43,000 subjects (18,222 cases and 24,778 controls) 8 10 13 19 20 21 22 23 24 25 26 27 28 29 30 32 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 . Of the 42 included studies, five studies involving 7,186 subjects reported on colorectal cancer (CRC).…”

Section: Resultsmentioning

confidence: 99%

“…The -94 ins/del ATTG (rs28362491) polymorphism that involves deletion of four nucleotides in the promoter region of NFKB1 gene consists of three genotypes: homozygote insertion or wild-type (WW), homozygote deletion or variant (DD), and heterozygous ins/del (DW) 7 18 . According to published data, several search groups have investigated the relationship between the polymorphism and cancers risk 7 10 19 20 21 22 23 24 25 26 27 . However, these results obtained remains inconsistent.…”

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confidence: 99%

“…Henceforth, some new studies further assessed the relationship between the polymorphism and cancer risk among multiple ethnic populations. However, the association remains inconclusive due to the inconsistent results from the published publications 23 24 25 26 27 30 36 37 38 39 40 41 42 . Therefore, the data need to be updated and more reliable evaluations of the polymorphism with cancer risk are warranted.…”

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confidence: 99%

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Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Xie

Wang

et al. 2016

Sci Rep

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Accumulating evidences have indicated that the functional -94 ins/del ATTG polymorphism in the promoter region of human nuclear factor-kappa B1 (NFKB1) gene may be associated with cancer risk. However, some studies yielded conflicting results. To clarify precise association, we performed a comprehensive meta-analysis of 42 case-control studies involving 43,000 subjects (18,222 cases and 24,778 controls). The overall results suggested that the -94 ins/del ATTG polymorphism had a decreased risk for cancer, reaching significant levels in five genetic models (dominant model: OR = 0.86, 95% CI = 0.79–0.95, P = 0.002; recessive model: OR = 0.84, 95% CI = 0.74–0.94, P = 0.003; homozygous model: OR = 0.77, 95% CI = 0.66–0.90, P = 0.001; heterozygous model: OR = 0.90, 95% CI = 0.83–0.98, P = 0.011; allelic model: OR = 0.89, 95% CI = 0.83–0.96, P = 0.002). Furthermore, the -94 ins/del ATTG polymorphism could confer a decreased or increased risk for cancer development among Asians and Caucasians, respectively. Additionally, the stratification analysis revealed a significant association between the variant and decreased risk of oral, ovarian, and nasopharyngeal cancer in Asians. After we adjusted p values using the Benjamini-Hochberg false discovery rate method to account for multiple comparisons, these associations remained.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Xie

Wang

et al. 2016

Sci Rep

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“…Recently, many studies have tested the association between different forms of cancer and functional variants of genes responsible for the inflammatory process [ 5 – 8 ], such as interleukin 1A ( IL1A ), interleukin 4 ( IL4 ), nuclear factor kappa B1 ( NFKB1 ) and protease-activated receptor 1 ( PAR1 ) [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, European and Brazilian populations

et al. 2016

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Background The inflammatory response plays a key role at different stages of cancer development. Allelic variants of the interleukin 1A (IL1A), interleukin 4 (IL4), nuclear factor kappa B1 (NFKB1) and protease-activated receptor 1 (PAR1) genes may influence not only the inflammatory response but also susceptibility to cancer development. Among major ethnic or continental groups, these polymorphic variants present different allelic frequencies. In admixed populations, such as the Brazilian population, data on distribution of these polymorphisms are limited. Here, we collected samples of cancer-free individuals from the north, northeast, midwest, south and southeast regions of Brazil and from the three main groups that gave rise to the Brazilian population: Native Americans from the Brazilian Amazon, Africans and Europeans. We describe the allelic distributions of four IL1A (rs3783553), IL4 (rs79071878), NFKB1 (rs28362491) and PAR1 (rs11267092) gene polymorphisms, which the literature describes as polymorphisms with a risk of cancer or worse prognosis for cancer.ResultsThe genotypic distribution of the four polymorphisms was statistically distinct between Native Americans, Africans and Europeans. For the allelic frequency of these polymorphisms, the Native American population was the most distinct among the three parental populations, and it included the greatest number of alleles with a risk of cancer or worse prognosis for cancer. The PAR1 gene polymorphism allelic distribution was similar among all Brazilian regions. For the other three markers, the northern region population was statistically distinct from other Brazilian region populations.ConclusionThe IL1A, IL4, NFKB1 and PAR1 gene polymorphism allelic distributions are homogeneous among the regional Brazilian populations, except for the northern region, which significantly differs from the other four Brazilian regions. Among the parental populations, the Native American population exhibited a higher incidence of alleles with risk of cancer or worse prognosis for cancer, which can indicate greater susceptibility to this disease. These genetic data may be useful for future studies on the association between these polymorphisms and cancer in the investigated populations.

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“…Survival (Murray et al 2013) rs230532, rs3774932 Clinical outcome Ovarian cancer (Fan et al 2011, Huo et al 2013, Chen et al 2015a, Lu et al 2016 rs230528, rs230521, rs4648068, rs3774964, rs3774968, rs28362491…”

Section: Type Of Endocrine-related Malignancymentioning

confidence: 99%

Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma

Plantinga¹,

Petrulea

Oosting³

et al. 2017

Endocrine-Related Cancer

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The NF-κB inflammatory pathway plays a major role in cancer development and clinical progression. Activation of NF-κB signaling is promoted by NFKB1 and inhibited by NFKBIA. The present study aimed to determine the relevance of rs4648068 and rs2233406 genetic variants for non-medullary thyroid cancer (NMTC) susceptibility, progression and clinical outcome. This case-control and cohort study consists of a Romanian discovery cohort (157 patients and 258 controls) and a Dutch validation cohort (138 patients and 188 controls). In addition, patient cohorts were analyzed further for the association of genetic variants with clinical parameters. Functional studies were performed on human peripheral blood mononuclear cells. No associations were observed between the studied genetic variants and TC susceptibility. Although no statistically significant associations with clinical parameters were observed for rs4648068, the heterozygous genotype of rs2233406 was correlated with decreased radioactive iodide sensitivity requiring higher cumulative dosages to achieve clinical response. These findings were discovered in the Romanian cohort ( < 0.001) and confirmed in the Dutch cohort ( = 0.01). Functional studies revealed that this rs2233406 genotype was associated with elevated TLR4-mediated IL-1β production. In conclusion, genetic variation in, an inhibitor of NF-κB signaling, is associated with clinical response to RAI therapy and with increased production of the pro-inflammatory cytokine IL-1β, providing a potential mechanism for the observed clinical associations. These data suggest that NF-κB signaling is involved in NMTC pathogenesis and that the inflammatory tumor microenvironment could contribute to RAI resistance.

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Association between genetic polymorphisms of inflammatory response genes and the risk of ovarian cancer

Abstract: NFKB1 and ICAM-1 polymorphisms could serve as useful ovarian cancer risk prediction biomarkers for the Chinese population, while the utility of PPARG and E-selectin polymorphisms as biomarkers requires further confirmation in independent ovarian cancer cohorts.

Cited by 14 publications

References 31 publications

Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Genetic association between NFKB1 −94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies

Distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, European and Brazilian populations

Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma

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