Association between genetic polymorphisms of NOD1, Interleukin‐1B, and cagA strain with low‐grade duodenal eosinophilia in Helicobacter pylori‐related dyspepsia
Abstract:BackgroundFunctional dyspepsia (FD) is a multifactorial disorder. Helicobacter pylori (H. pylori)‐related dyspepsia (HpD) may be considered a separate entity. Duodenal eosinophilia is a potential pathogenic mechanism in FD. However, the impact of duodenal eosinophilia and host genetic polymorphism of innate and pro‐inflammatory cascade, nucleotide‐binding oligomerization domain 1 (NOD‐1), and interleukin‐1 beta (IL‐1β) in HpD was not explored.AimTo evaluate the association of NOD1‐796G>A and IL‐1B‐511C>T… Show more
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