Association between gait variability and brain ventricle attributes: a brain mapping study

Annweiler, Cédric; Montero‐Odasso, Manuel; Bartha, Robert; Drozd, John; Hachinski, Vladimir; Beauchet, Olivier

doi:10.1016/j.exger.2014.06.015

Cited by 32 publications

(51 citation statements)

References 42 publications

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“…Furthermore, a significant negative association between greater gait variability and lower hippocampal volume has been also shown in CHI (Albert et al, 2011;Dubois et al, 2014;Zimmerman et al, 2009;Shimada et al, 2013;Rosso et al, 2014;Annweiler et al, 2014). Thus, we hypothesized at first that higher gait variability would be stronger associated with lower hippocampal volume in patients with MCI individuals compared to CHI.…”

Section: Discussionmentioning

confidence: 89%

“…In contrast to its prominent function in cognition, the involvement of the hippocampus in gait control, and thus in the maintenance of gait stability, is still a matter of debate. For instance and when considering the hippocampal volume, Zimmermann et al reported a non-significant association between hippocampal volume and stride-to-stride variability, whereas other studies showed a significant negative association (Zimmerman et al, 2009;Shimada et al, 2013;Rosso et al, 2014;Annweiler et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Negative results have been found in the unique study that examined both cognitive healthy individuals (CHI) and patients with MCI, whereas all other studies focused on CHI (Zimmerman et al, 2009;Shimada et al, 2013;Rosso et al, 2014;Annweiler et al, 2014). In terms of control of gait, gait variability has been identified as an appropriate biomarker for the measure of the cortical control of gait in normal aging and in patients with dementia (Beauchet et al, 2009aMontero-Odasso et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Because it has been shown that patients with MCI present independently a greater gait variability and a lower hippocampal volume compared to CHI (Albert et al, 2011;Dubois et al, 2014;Zimmerman et al, 2009;Shimada et al, 2013;Rosso et al, 2014;Annweiler et al, 2014), we hypothesized that higher gait variability would be stronger associated with lower hippocampal volume in MCI individuals compared to CHI. We had the opportunity to test this hypothesis in the "Gait and Alzheimer Interactions Tracking" (GAIT) study, which is a crosssectional study aiming to compare gait characteristics of CHI and patients with MCI and AD, and to examine the association between gait characteristics and brain morphology.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal volume, early cognitive decline and gait variability: Which association?

Beauchet

Launay

Annweiler

et al. 2015

Experimental Gerontology

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Background: In contrast to its prominent function in cognition, the involvement of the hippocampus in gait control is still a matter of debate. The present study aimed to examine the association of the hippocampal volume with mean values and coefficients of variation (CoV) of spatio-temporal gait parameters among cognitively healthy individuals (CHI) and patients with mild cognitive impairment (MCI). Methods: A total of 90 individuals (47 CHI with a mean age of 69.7 ± 3.6 years and 48.9% women, and 43 MCI individuals with a mean age of 70.2 ± 3.7 years and 62.8% women) were included in this cross-sectional study. The hippocampal volume was quantified from a three-dimensional T 1 -weighted MRI using semiautomated software. Mean values and CoV of stride time, swing time and stride width were measured at selfselected pace with a 10 m electronic portable walkway (GAITRite®). Age, gender, body mass index, number of drugs daily taken, Mini-Mental State Examination (MMSE) score, history of falls, walking speed and white matter signal-intensity abnormality scoring with Manolio scale were used as covariates. Results: Patients with MCI had a lower MMSE score (P b 0.001), a higher CoV of stride time (P = 0.013) and a lower hippocampal volume (P = 0.007) compared with CHI. Multiple linear regression models showed that CoV of stride time was specifically associated with higher hippocampal volume among CHI (P b 0.05) but not among patients with MCI (P N 0.650). Conclusions: Our findings revealed a positive association between a greater (i.e., better morphological structure) hippocampal volume and a greater (i.e., worse performance) stride time variability among CHI, but not among MCI individuals.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hippocampal volume, early cognitive decline and gait variability: Which association?

Beauchet

Launay

Annweiler

et al. 2015

Experimental Gerontology

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“…We focused on these stride time parameters because both of them have been previously linked with cognition Hausdorff et al 2005 and with gait control (Allali et al 2010;Annweiler et al 2013;Annweiler et al 2014;Beauchet et al 2014a, b). The GAITRite® system is an electronic walkway-integrated and pressure-sensitive electronic surface of 5.6 × 0.89 m, with an active surface length of 4.8 m, connected to a personal portable computer via an interface cable.…”

Section: Clinical Assessmentmentioning

confidence: 99%

Episodic memory and executive function impairments in non-demented older adults: which are the respective and combined effects on gait performances?

Beauchet

Launay

Fantino

et al. 2015

AGE

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Gait control depends in part on cognition. This study aims to examine the separate and combined effects of episodic memory and executive function impairments on the mean value and the coefficient of variation (CoV) of stride time among non-demented older community dwellers. Based on a cross-sectional design, 1458 older community dwellers without dementia (70.6 ± 4.9 years; 49.2 % female) were recruited and separated into cognitively healthy individuals (CHI) and individuals with cognitive impairment. A score ≤5/6 on the Short MiniMental State Examination defined episodic memory impairment. Impaired executive function was defined by errors on the clock-drawing test. Mean value and CoVof stride time were measured by the GAITRite® system. A total of 517 participants (35.5 %) had cognitive impairment in at least one cognitive domain. Participants with memory impairment (P = 0.006) and those with combined cognitive impairments (P < 0.001) had greater (i.e., worse gait performance) mean value of stride time (P = 0.006) compared to CHI. Participants with combined cognitive impairment had a greater CoV of stride time (i.e., worse gait performance) compared to CHI (P = 0.004) and to those with separate memory impairment (P = 0.037). Among participants with combined cognitive impairments, mean value and CoV of stride time had the highest effect size (respectively, effect size = 0.49 [95 % confidence interval (CI) 0.27;0.71] and effect size = 0.40 [95 %CI 0.18;0.62]). Participants with episodic memory or executive impairments had a greater mean value and CoV of stride time compared to those with no cognitive impairment. Combined episodic memory and executive impairments exceeded the sum of separate impairments on gait performances, suggesting a complex interplay going beyond a simple additive effect.

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Gait Variability and Fall Risk in Older Adults: The Role of Cognitive Function

Pieruccini‐Faria

Montero‐Odasso

Hausdorff

2019

Falls and Cognition in Older Persons

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Association between gait variability and brain ventricle attributes: a brain mapping study

Cited by 32 publications

References 42 publications

Hippocampal volume, early cognitive decline and gait variability: Which association?

Hippocampal volume, early cognitive decline and gait variability: Which association?

Episodic memory and executive function impairments in non-demented older adults: which are the respective and combined effects on gait performances?

Gait Variability and Fall Risk in Older Adults: The Role of Cognitive Function

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