Association between Functional Variables and Heart Failure after Myocardial Infarction in Rats

Polegato, Bertha Furlan; Minicucci, Marcos F.; Azevedo, Paula Schmidt; Gonçalves, Andréa; Lima, Aline Fátima Andrade de; Martinez, Paula Felippe; Okoshi, Marina Politi; Okoshi, Katashi; Paiva, Sérgio Alberto Rupp de; Zornoff, Leonardo A. M.

doi:10.5935/abc.20160015

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Cardiac remodeling can be defined as molecular, cellular, and interstitial modifications that are clinically manifested as changes in size, mass, geometry and heart function after cardiac injury. Heart dysfunction is the final sign of cardiac remodeling and is an important prognostic factor after MI, increasing the risk of death[ 45 , 46 ]. Diastolic dysfunction after MI refers to mechanical and functional abnormalities during relaxation and filling of the LV and is associated with hypertrophy and increased LA[ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

et al. 2017

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BackgroundMyocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown.Methods and resultsTo determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively.ConclusionOur findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling.

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Section: Discussionmentioning

confidence: 99%

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

et al. 2017

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“…The cardiac function was reduced in MI-induced heart failure rats [ 27 ], mice [ 28 , 29 ], rabbits [ 30 ], and swines [ 31 ]. In the present study, the results showed that the EF and FS of LV in MI-induced heart failure rats were reduced, which were improved by miR-132 agomiR.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats

Wang

Ruan

et al. 2020

Bioscience Reports

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The aim of the present study was to determine the effect of microRNA (miR)-132 on cardiac fibrosis in myocardial infarction (MI)-induced heart failure and angiotensin (Ang) II-treated cardiac fibroblasts (CFs). Experiments were carried out in Sprague-Dawley rat treatment with ligation of left coronary artery to induce heart failure, and in CFs administration of Ang II to induce fibrosis. The level of miR-132 was increased in the heart of rats with MI-induced heart failure and the Ang II-treated CFs. In MI rats, left ventricle (LV) ejection fraction, fractional shortening, the maximum of the first differentiation of LV pressure (LV +dp/dtmax) and decline (LV -dp/dtmax) and LV systolic pressure (LVSP) were reduced, and LV end-systolic diameter (LVESD), LV end-diastolic diameter (LVEDD), LV volumes in systole (LVVS) and LV volumes in diastole (LVVD) were increased, which were reversed by miR-132 agomiR but deteriorated by miR-132 antagomiR. The expression levels of collagen I, collagen III, transforming growth factor-β (TGF-β), and α-smooth muscle actin (α-SMA) were increased in the heart of rat with MI-induced heart failure and CFs administration of Ang II. These increases were inhibited by miR-132 agomiR but enhanced by miR-132 antagomiR treatment. MiR-132 inhibited PTEN expression, and attenuated PI3K/Akt signal pathway in CFs. These results indicated that the upregulation of miR-132 improved the cardiac dysfunction, attenuated cardiac fibrosis in heart failure via inhibiting PTEN expression, and attenuating PI3K/Akt signal pathway. Upregulation of miR-132 may be a strategy for the treatment of heart failure and cardiac fibrosis.

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“…Heart failure was considered when three criteria were met: Pulmonary congestion: a) percentage of lung humidity above 80%; b) lung/body weight (BW) ratio greater than lung/BW approximately 2-fold in relation to C [21]; c) right lung/BW above 5 mg/g [22]. RV hypertrophy: characterized by the ratio of the weight of RV adjusted by BW above 0.8 mg/g [23]. Elevated LVEDP: LV end diastolic pressure (LVEDP) greater than 15 mmHg [24,25]; and Systolic dysfunction: maximum positive value of the first derivative of LV systolic pressure above 7000 mmHg [22].…”

Section: Heart Failurementioning

confidence: 99%

Hypercaloric diet models do not develop heart failure, but the excess sucrose promotes contractility dysfunction

et al. 2020

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Several diseases are associated with excess of adipose tissue, and obesity is considered an independent risk factor for the development of cardiac remodeling and heart failure. Dietary aspects have been studied to elucidate the mechanisms involved in these processes. Thus, the purpose was the development and characterization of an obesity experimental model from hypercaloric diets, which resulted in cardiac remodeling and predisposition to heart failure. Thirty-day-old male Wistar rats (n = 52) were randomized into four groups: control (C), high sucrose (HS), high-fat (HF) and high-fat and sucrose (HFHS) for 20 weeks. General characteristics, comorbidities, weights of the heart, left (LV) and right ventricles, atrium, and relationships with the tibia length were evaluated. The LV myocyte cross sectional area and fraction of interstitial collagen were assayed. Cardiac function was determined by hemodynamic analysis and the contractility by cardiomyocyte contractile function. Heart failure was analyzed by pulmonary congestion, right ventricular hypertrophy, and hemodynamic parameters. HF and HFHS models led to obesity by increase in adiposity index (C = 8.3 ± 0.2% vs. HF = 10.9 ± 0.5%, HFHS = 10.2 ± 0.3%). There was no change in the morphological parameters and heart failure signals. HF and HFHS caused a reduction in times to 50% relaxation without cardiomyocyte contractile damage. The HS model presented cardiomyocyte contractile dysfunction visualized by lower shortening (C: 8.34 ± 0.32% vs. HS: 6.91 ± 0.28), as well as the Ca 2+ transient amplitude was also increased when compared to HFHS. In conclusion, the experimental diets based on high amounts of sugar, lard or a combination of both did not promote cardiac remodeling with predisposition to heart failure under conditions of obesity or excess sucrose. Nevertheless, excess sucrose causes cardiomyocyte contractility dysfunction associated with alterations in the myocyte sensitivity to intracellular Ca 2+ .

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Association between Functional Variables and Heart Failure after Myocardial Infarction in Rats

Cited by 6 publications

References 30 publications

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats

Hypercaloric diet models do not develop heart failure, but the excess sucrose promotes contractility dysfunction

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